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Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men.
PLoS One. 2013; 8(7):e67152.Plos

Abstract

Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance. We aimed to determine the independent relationship between SUA and NAFLD in non-diabetic Chinese male population, and to explore the determinants of SUA levels among indexes of adiposity, lipid, and genotypes pertaining to triglycerides metabolism, inflammation, oxidative stress, and SUA concentrations. A total of 1440 men, classified depending on the presence of ultrasonographically detected NAFLD, underwent a complete healthy checkup program. Genotypes were extracted from our previously established genome-wide association study database. After adjusting for age, smoking, drinking, body mass index, homeostasis model assessment of insulin resistance, C-reactive protein, creatinine, alanine aminotransferase (ALT) and components of metabolic syndrome, the odds ratio for NAFLD, comparing the highest with the lowest SUA quartile, was 2.81 (95% confidence interval 1.66-4.76). A stepwise multivariate linear regression analysis (R(2) = 0.238, P<0.001) retained age, waist circumference, serum creatinine, triglycerides, the Q141K variant in ABCG2 (rs2231142) and NAFLD as significant predictors of SUA levels (all P<0.001). Besides, ALT and Met196Arg variant in TNFRSF1B (rs1061622) additionally associated with SUA among individuls with NAFLD. Our data suggest that in Chinese men, elevated SUA is significantly associated with NAFLD, independent of insulin resistance and other metabolic disorders, such as central obesity or hypertriglyceridemia. Meanwhile, among subjects with NAFLD, index of liver damage, such as elevated ALT combined with genetic susceptibility to inflammation associated with increased SUA levels.

Authors+Show Affiliations

Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23935829

Citation

Xie, Yuanliang, et al. "Serum Uric Acid and Non-alcoholic Fatty Liver Disease in Non-diabetic Chinese Men." PloS One, vol. 8, no. 7, 2013, pp. e67152.
Xie Y, Wang M, Zhang Y, et al. Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. PLoS One. 2013;8(7):e67152.
Xie, Y., Wang, M., Zhang, Y., Zhang, S., Tan, A., Gao, Y., Liang, Z., Shi, D., Huang, Z., Zhang, H., Yang, X., Lu, Z., Wu, C., Liao, M., Sun, Y., Qin, X., Hu, Y., Li, L., Peng, T., ... Mo, Z. (2013). Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. PloS One, 8(7), e67152. https://doi.org/10.1371/journal.pone.0067152
Xie Y, et al. Serum Uric Acid and Non-alcoholic Fatty Liver Disease in Non-diabetic Chinese Men. PLoS One. 2013;8(7):e67152. PubMed PMID: 23935829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. AU - Xie,Yuanliang, AU - Wang,Mengjie, AU - Zhang,Youjie, AU - Zhang,Shijun, AU - Tan,Aihua, AU - Gao,Yong, AU - Liang,Zhengjia, AU - Shi,Deyi, AU - Huang,Zhang, AU - Zhang,Haiying, AU - Yang,Xiaobo, AU - Lu,Zheng, AU - Wu,Chunlei, AU - Liao,Ming, AU - Sun,Yu, AU - Qin,Xue, AU - Hu,Yanling, AU - Li,Li, AU - Peng,Tao, AU - Li,Zhixian, AU - Yang,Xiaoli, AU - Mo,Zengnan, Y1 - 2013/07/23/ PY - 2013/02/28/received PY - 2013/05/15/accepted PY - 2013/8/13/entrez PY - 2013/8/13/pubmed PY - 2014/3/7/medline SP - e67152 EP - e67152 JF - PloS one JO - PLoS One VL - 8 IS - 7 N2 - Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance. We aimed to determine the independent relationship between SUA and NAFLD in non-diabetic Chinese male population, and to explore the determinants of SUA levels among indexes of adiposity, lipid, and genotypes pertaining to triglycerides metabolism, inflammation, oxidative stress, and SUA concentrations. A total of 1440 men, classified depending on the presence of ultrasonographically detected NAFLD, underwent a complete healthy checkup program. Genotypes were extracted from our previously established genome-wide association study database. After adjusting for age, smoking, drinking, body mass index, homeostasis model assessment of insulin resistance, C-reactive protein, creatinine, alanine aminotransferase (ALT) and components of metabolic syndrome, the odds ratio for NAFLD, comparing the highest with the lowest SUA quartile, was 2.81 (95% confidence interval 1.66-4.76). A stepwise multivariate linear regression analysis (R(2) = 0.238, P<0.001) retained age, waist circumference, serum creatinine, triglycerides, the Q141K variant in ABCG2 (rs2231142) and NAFLD as significant predictors of SUA levels (all P<0.001). Besides, ALT and Met196Arg variant in TNFRSF1B (rs1061622) additionally associated with SUA among individuls with NAFLD. Our data suggest that in Chinese men, elevated SUA is significantly associated with NAFLD, independent of insulin resistance and other metabolic disorders, such as central obesity or hypertriglyceridemia. Meanwhile, among subjects with NAFLD, index of liver damage, such as elevated ALT combined with genetic susceptibility to inflammation associated with increased SUA levels. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23935829/Serum_uric_acid_and_non_alcoholic_fatty_liver_disease_in_non_diabetic_Chinese_men_ L2 - https://dx.plos.org/10.1371/journal.pone.0067152 DB - PRIME DP - Unbound Medicine ER -