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Hypovitaminosis D is independently associated with metabolic syndrome in obese patients.
PLoS One. 2013; 8(7):e68689.Plos

Abstract

BACKGROUND

Metabolic syndrome (MS) and hypovitaminosis D represent two of the most diffuse condition worldwide, reaching pandemic proportions in industrialized countries, and are both strongly associated with obesity. This study set out to evaluate the presence of an independent association between hypovitaminosis D and MS in an adult population of obese subjects with/without MS.

METHODS

We recruited 107 consecutive obese subjects, 61 with MS (age(mean±SD) 45.3±13.3 years, BMI(mean±SD): 43.1±8.3 kg/m(2)) and 46 without MS (age: 41.8±11.5, p = n.s., BMI:41.6±6.5 kg/m(2), p = n.s.) comparable for sex, BMI, waist circumference and body fat mass, evaluated by bioimpedentiometry. 25(OH) vitamin D3 levels were measured by colorimetric method. Insulin resistance was estimated by fasting blood insulin, HOMA-IR and ISI.

RESULTS

Serum 25(OH)D3 levels were significantly lower in MS obese patients than in obese subjects without MS (median(range) 13.5(3.3-32) vs 17.4(5.1-37.4), p<0.007). Low 25(OH)D3 levels correlated with glycaemia (p<0.007), phosphate (p<0.03), PTH (p<0.003) and the MS (p<0.001). Multivariate model confirmed that low 25(OH)D3 levels were associated with the diagnosis of MS in obese patients independently from gender, age, serum PTH and body fat mass. After stratifying the study population according to 25(OH)D3 concentrations, patients in the lowest quartile showed a markedly increased prevalence of MS compared to those in the highest quartile (OR = 4.1, CI 1.2-13.7, p = 0.02).

CONCLUSIONS

A powerful association exists between hypovitaminosis D and MS in obese patients independently from body fat mass and its clinical correlates. This indicates that the association between low 25(OH) D3 levels and MS is not merely induced by vitamin D deposition in fat tissue and reinforces the hypothesis that hypovitaminosis D represent a crucial independent determinant of MS.

Authors+Show Affiliations

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23935881

Citation

Barchetta, Ilaria, et al. "Hypovitaminosis D Is Independently Associated With Metabolic Syndrome in Obese Patients." PloS One, vol. 8, no. 7, 2013, pp. e68689.
Barchetta I, De Bernardinis M, Capoccia D, et al. Hypovitaminosis D is independently associated with metabolic syndrome in obese patients. PLoS ONE. 2013;8(7):e68689.
Barchetta, I., De Bernardinis, M., Capoccia, D., Baroni, M. G., Fontana, M., Fraioli, A., Morini, S., Leonetti, F., & Cavallo, M. G. (2013). Hypovitaminosis D is independently associated with metabolic syndrome in obese patients. PloS One, 8(7), e68689. https://doi.org/10.1371/journal.pone.0068689
Barchetta I, et al. Hypovitaminosis D Is Independently Associated With Metabolic Syndrome in Obese Patients. PLoS ONE. 2013;8(7):e68689. PubMed PMID: 23935881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypovitaminosis D is independently associated with metabolic syndrome in obese patients. AU - Barchetta,Ilaria, AU - De Bernardinis,Marzia, AU - Capoccia,Danila, AU - Baroni,Marco Giorgio, AU - Fontana,Mario, AU - Fraioli,Antonio, AU - Morini,Sergio, AU - Leonetti,Frida, AU - Cavallo,Maria Gisella, Y1 - 2013/07/31/ PY - 2013/03/05/received PY - 2013/06/02/accepted PY - 2013/8/13/entrez PY - 2013/8/13/pubmed PY - 2014/4/22/medline SP - e68689 EP - e68689 JF - PloS one JO - PLoS ONE VL - 8 IS - 7 N2 - BACKGROUND: Metabolic syndrome (MS) and hypovitaminosis D represent two of the most diffuse condition worldwide, reaching pandemic proportions in industrialized countries, and are both strongly associated with obesity. This study set out to evaluate the presence of an independent association between hypovitaminosis D and MS in an adult population of obese subjects with/without MS. METHODS: We recruited 107 consecutive obese subjects, 61 with MS (age(mean±SD) 45.3±13.3 years, BMI(mean±SD): 43.1±8.3 kg/m(2)) and 46 without MS (age: 41.8±11.5, p = n.s., BMI:41.6±6.5 kg/m(2), p = n.s.) comparable for sex, BMI, waist circumference and body fat mass, evaluated by bioimpedentiometry. 25(OH) vitamin D3 levels were measured by colorimetric method. Insulin resistance was estimated by fasting blood insulin, HOMA-IR and ISI. RESULTS: Serum 25(OH)D3 levels were significantly lower in MS obese patients than in obese subjects without MS (median(range) 13.5(3.3-32) vs 17.4(5.1-37.4), p<0.007). Low 25(OH)D3 levels correlated with glycaemia (p<0.007), phosphate (p<0.03), PTH (p<0.003) and the MS (p<0.001). Multivariate model confirmed that low 25(OH)D3 levels were associated with the diagnosis of MS in obese patients independently from gender, age, serum PTH and body fat mass. After stratifying the study population according to 25(OH)D3 concentrations, patients in the lowest quartile showed a markedly increased prevalence of MS compared to those in the highest quartile (OR = 4.1, CI 1.2-13.7, p = 0.02). CONCLUSIONS: A powerful association exists between hypovitaminosis D and MS in obese patients independently from body fat mass and its clinical correlates. This indicates that the association between low 25(OH) D3 levels and MS is not merely induced by vitamin D deposition in fat tissue and reinforces the hypothesis that hypovitaminosis D represent a crucial independent determinant of MS. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23935881/Hypovitaminosis_D_is_independently_associated_with_metabolic_syndrome_in_obese_patients_ L2 - http://dx.plos.org/10.1371/journal.pone.0068689 DB - PRIME DP - Unbound Medicine ER -