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Marijuana's dose-dependent effects in daily marijuana smokers.
Exp Clin Psychopharmacol. 2013 Aug; 21(4):287-93.EC

Abstract

Active marijuana produces significant subjective, psychomotor, and physiological effects relative to inactive marijuana, yet demonstrating that these effects are dose-dependent has proven difficult. This within-subject, double-blind study was designed to develop a smoking procedure to obtain a marijuana dose-response function. In four outpatient laboratory sessions, daily marijuana smokers (N = 17 males, 1 female) smoked six 5-s puffs from 3 marijuana cigarettes (2 puffs/cigarette). The number of puffs from active (≥5.5% Δ⁹-tetrahydrocannabinol/THC) and inactive (0.0% THC) marijuana varied according to condition (0, 2, 4, or 6 active puffs); active puffs were always smoked before inactive puffs. Subjective, physiological, and performance effects were assessed prior to and at set time points after marijuana administration. Active marijuana dose-dependently increased heart rate and decreased marijuana craving, despite evidence (carbon monoxide expiration, weight of marijuana cigarettes post-smoking) that participants inhaled less of each active marijuana cigarette than inactive cigarettes. Subjective ratings of marijuana "strength," "high," "liking," "good effect," and "take again" were increased by active marijuana compared with inactive marijuana, but these effects were not dose-dependent. Active marijuana also produced modest, non-dose-dependent deficits in attention, psychomotor function, and recall relative to the inactive condition. In summary, although changes in inhalation patterns as a function of marijuana strength likely minimized the difference between dose conditions, dose-dependent differences in marijuana's cardiovascular effects and ratings of craving were observed, whereas subjective ratings of marijuana effects did not significantly vary as a function of dose.

Authors+Show Affiliations

Division on Substance Abuse, New York Psychiatric Institute, New York, NY, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23937597

Citation

Ramesh, Divya, et al. "Marijuana's Dose-dependent Effects in Daily Marijuana Smokers." Experimental and Clinical Psychopharmacology, vol. 21, no. 4, 2013, pp. 287-93.
Ramesh D, Haney M, Cooper ZD. Marijuana's dose-dependent effects in daily marijuana smokers. Exp Clin Psychopharmacol. 2013;21(4):287-93.
Ramesh, D., Haney, M., & Cooper, Z. D. (2013). Marijuana's dose-dependent effects in daily marijuana smokers. Experimental and Clinical Psychopharmacology, 21(4), 287-93. https://doi.org/10.1037/a0033661
Ramesh D, Haney M, Cooper ZD. Marijuana's Dose-dependent Effects in Daily Marijuana Smokers. Exp Clin Psychopharmacol. 2013;21(4):287-93. PubMed PMID: 23937597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marijuana's dose-dependent effects in daily marijuana smokers. AU - Ramesh,Divya, AU - Haney,Margaret, AU - Cooper,Ziva D, PY - 2013/8/14/entrez PY - 2013/8/14/pubmed PY - 2014/3/13/medline SP - 287 EP - 93 JF - Experimental and clinical psychopharmacology JO - Exp Clin Psychopharmacol VL - 21 IS - 4 N2 - Active marijuana produces significant subjective, psychomotor, and physiological effects relative to inactive marijuana, yet demonstrating that these effects are dose-dependent has proven difficult. This within-subject, double-blind study was designed to develop a smoking procedure to obtain a marijuana dose-response function. In four outpatient laboratory sessions, daily marijuana smokers (N = 17 males, 1 female) smoked six 5-s puffs from 3 marijuana cigarettes (2 puffs/cigarette). The number of puffs from active (≥5.5% Δ⁹-tetrahydrocannabinol/THC) and inactive (0.0% THC) marijuana varied according to condition (0, 2, 4, or 6 active puffs); active puffs were always smoked before inactive puffs. Subjective, physiological, and performance effects were assessed prior to and at set time points after marijuana administration. Active marijuana dose-dependently increased heart rate and decreased marijuana craving, despite evidence (carbon monoxide expiration, weight of marijuana cigarettes post-smoking) that participants inhaled less of each active marijuana cigarette than inactive cigarettes. Subjective ratings of marijuana "strength," "high," "liking," "good effect," and "take again" were increased by active marijuana compared with inactive marijuana, but these effects were not dose-dependent. Active marijuana also produced modest, non-dose-dependent deficits in attention, psychomotor function, and recall relative to the inactive condition. In summary, although changes in inhalation patterns as a function of marijuana strength likely minimized the difference between dose conditions, dose-dependent differences in marijuana's cardiovascular effects and ratings of craving were observed, whereas subjective ratings of marijuana effects did not significantly vary as a function of dose. SN - 1936-2293 UR - https://www.unboundmedicine.com/medline/citation/23937597/Marijuana's_dose_dependent_effects_in_daily_marijuana_smokers_ L2 - http://content.apa.org/journals/pha/21/4/287 DB - PRIME DP - Unbound Medicine ER -