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Reappraisal of the oxygenation of blood in varicose veins.
Br J Surg. 1990 Aug; 77(8):934-6.BJ

Abstract

Raised oxygen tension in the blood of varicose veins has led to arteriovenous communications being implicated in the pathogenesis of varicose veins. The aim of this study was to compare the oxygen tension of blood from varicose veins with that from normal legs, and to observe the effect of posture on these measurements. Twenty-six subjects (13 normal controls and 13 with uncomplicated varicose veins) had blood sampled from the long saphenous vein or a varicose vein near the ankle. Samples were taken after 30 min in the supine position and repeated after 30 min standing. Samples were also taken simultaneously from the arm. Transcutaneous oxygen measurements of the gaiter skin were performed continuously throughout the experiment. In the supine position, blood from varicose veins had a significantly higher oxygen tension (median = 6.09 kPa) than that from normal veins (median = 4.54 kPa) (P = 0.022). In all subjects, there was a higher oxygen tension in leg vein blood when lying (varicose vein median value = 6.09 kPa, control median value = 4.54 kPa) than while standing (varicose vein median value = 3.93 kPa, control median value = 3.74 kPa) (P less than 0.002, varicose vein group; P = 0.005, normal group). Changes in transcutaneous oxygen tension correlate poorly with changes in venous blood. It is concluded that the theory of arteriovenous anastomoses is only one among a number of possible explanations for the pathogenesis of varicose veins.

Authors+Show Affiliations

Department of Surgical Studies, University College and Middlesex School of Medicine, Middlesex Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2393822

Citation

Scott, H J., et al. "Reappraisal of the Oxygenation of Blood in Varicose Veins." The British Journal of Surgery, vol. 77, no. 8, 1990, pp. 934-6.
Scott HJ, Cheatle TR, McMullin GM, et al. Reappraisal of the oxygenation of blood in varicose veins. Br J Surg. 1990;77(8):934-6.
Scott, H. J., Cheatle, T. R., McMullin, G. M., Coleridge Smith, P. D., & Scurr, J. H. (1990). Reappraisal of the oxygenation of blood in varicose veins. The British Journal of Surgery, 77(8), 934-6.
Scott HJ, et al. Reappraisal of the Oxygenation of Blood in Varicose Veins. Br J Surg. 1990;77(8):934-6. PubMed PMID: 2393822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reappraisal of the oxygenation of blood in varicose veins. AU - Scott,H J, AU - Cheatle,T R, AU - McMullin,G M, AU - Coleridge Smith,P D, AU - Scurr,J H, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 934 EP - 6 JF - The British journal of surgery JO - Br J Surg VL - 77 IS - 8 N2 - Raised oxygen tension in the blood of varicose veins has led to arteriovenous communications being implicated in the pathogenesis of varicose veins. The aim of this study was to compare the oxygen tension of blood from varicose veins with that from normal legs, and to observe the effect of posture on these measurements. Twenty-six subjects (13 normal controls and 13 with uncomplicated varicose veins) had blood sampled from the long saphenous vein or a varicose vein near the ankle. Samples were taken after 30 min in the supine position and repeated after 30 min standing. Samples were also taken simultaneously from the arm. Transcutaneous oxygen measurements of the gaiter skin were performed continuously throughout the experiment. In the supine position, blood from varicose veins had a significantly higher oxygen tension (median = 6.09 kPa) than that from normal veins (median = 4.54 kPa) (P = 0.022). In all subjects, there was a higher oxygen tension in leg vein blood when lying (varicose vein median value = 6.09 kPa, control median value = 4.54 kPa) than while standing (varicose vein median value = 3.93 kPa, control median value = 3.74 kPa) (P less than 0.002, varicose vein group; P = 0.005, normal group). Changes in transcutaneous oxygen tension correlate poorly with changes in venous blood. It is concluded that the theory of arteriovenous anastomoses is only one among a number of possible explanations for the pathogenesis of varicose veins. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/2393822/Reappraisal_of_the_oxygenation_of_blood_in_varicose_veins_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1323&date=1990&volume=77&issue=8&spage=934 DB - PRIME DP - Unbound Medicine ER -