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Sustained response to deep brain stimulation in LRRK2 parkinsonism with the Y1699C mutation.
J Parkinsons Dis. 2012; 2(4):269-71.JP

Abstract

Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a marked improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores in the "on" and "off" states, sustained for more than three years. Bilateral STN-DBS in LRRK2-parkinsonism with the Y1699C mutation can be as effective as in sporadic PD.

Authors+Show Affiliations

Department of Neurosciences, Monash Medical Centre, Clayton, VIC, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23938256

Citation

Perju-Dumbrava, L D., et al. "Sustained Response to Deep Brain Stimulation in LRRK2 Parkinsonism With the Y1699C Mutation." Journal of Parkinson's Disease, vol. 2, no. 4, 2012, pp. 269-71.
Perju-Dumbrava LD, McDonald M, Kneebone AC, et al. Sustained response to deep brain stimulation in LRRK2 parkinsonism with the Y1699C mutation. J Parkinsons Dis. 2012;2(4):269-71.
Perju-Dumbrava, L. D., McDonald, M., Kneebone, A. C., Long, R., & Thyagarajan, D. (2012). Sustained response to deep brain stimulation in LRRK2 parkinsonism with the Y1699C mutation. Journal of Parkinson's Disease, 2(4), 269-71. https://doi.org/10.3233/JPD-012121
Perju-Dumbrava LD, et al. Sustained Response to Deep Brain Stimulation in LRRK2 Parkinsonism With the Y1699C Mutation. J Parkinsons Dis. 2012;2(4):269-71. PubMed PMID: 23938256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained response to deep brain stimulation in LRRK2 parkinsonism with the Y1699C mutation. AU - Perju-Dumbrava,L D, AU - McDonald,M, AU - Kneebone,A C, AU - Long,R, AU - Thyagarajan,D, PY - 2013/8/14/entrez PY - 2012/1/1/pubmed PY - 2014/6/27/medline SP - 269 EP - 71 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 2 IS - 4 N2 - Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a marked improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores in the "on" and "off" states, sustained for more than three years. Bilateral STN-DBS in LRRK2-parkinsonism with the Y1699C mutation can be as effective as in sporadic PD. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/23938256/Sustained_response_to_deep_brain_stimulation_in_LRRK2_parkinsonism_with_the_Y1699C_mutation_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JPD-012121 DB - PRIME DP - Unbound Medicine ER -