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Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease.
J Parkinsons Dis. 2011; 1(3):277-86.JP

Abstract

Progressive rostral spread of Lewy body (LB) pathology is thought to reflect the clinical course of Parkinson's disease (PD) although several studies have suggested that LBs are not the toxic species responsible for cell death. We investigated the relationship between nigral dopaminergic cell loss, distribution and density of α-synuclein-immunoreactive LBs and duration of motor symptoms in 97 patients with PD. Density of pigmented neurons was measured in a single section of one half of the substantia nigra (SN) with delineation of the dorsal and ventral tiers whereas the cortical and nigral LB densities were determined using a morphometric approach. The density of nigral neurons was estimated to decrease by 2% each year after confirmation of the clinical diagnosis of PD but showed marked heterogeneity with some PD patients with longer duration of illness still possessing a significant number of preserved pigmented nigral neurons at the time of death. An average 15% of surviving nigral neurones contained LBs and the age-adjusted proportion of LB-bearing neurons appeared relatively stable throughout the disease duration. No difference was observed in the age at death or duration of disease with respect to Braak PD stages. The nigral neuronal density was unrelated to either the Braak PD stage or to cortical LB densities. We conclude that nigral neuronal loss is slow and shows considerable variation in PD. Our data also provides no support for a primary pathogenic role of LBs as neither their distribution nor density was associated with the severity of nigral cell loss.

Authors+Show Affiliations

Queen Square Brain Bank for Neurological Disorders, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23939308

Citation

Parkkinen, Laura, et al. "Disentangling the Relationship Between Lewy Bodies and Nigral Neuronal Loss in Parkinson's Disease." Journal of Parkinson's Disease, vol. 1, no. 3, 2011, pp. 277-86.
Parkkinen L, O'Sullivan SS, Collins C, et al. Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease. J Parkinsons Dis. 2011;1(3):277-86.
Parkkinen, L., O'Sullivan, S. S., Collins, C., Petrie, A., Holton, J. L., Revesz, T., & Lees, A. J. (2011). Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease. Journal of Parkinson's Disease, 1(3), 277-86. https://doi.org/10.3233/JPD-2011-11046
Parkkinen L, et al. Disentangling the Relationship Between Lewy Bodies and Nigral Neuronal Loss in Parkinson's Disease. J Parkinsons Dis. 2011;1(3):277-86. PubMed PMID: 23939308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease. AU - Parkkinen,Laura, AU - O'Sullivan,Sean S, AU - Collins,Catherine, AU - Petrie,Aviva, AU - Holton,Janice L, AU - Revesz,Tamas, AU - Lees,Andrew J, PY - 2013/8/14/entrez PY - 2011/1/1/pubmed PY - 2014/7/8/medline SP - 277 EP - 86 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 1 IS - 3 N2 - Progressive rostral spread of Lewy body (LB) pathology is thought to reflect the clinical course of Parkinson's disease (PD) although several studies have suggested that LBs are not the toxic species responsible for cell death. We investigated the relationship between nigral dopaminergic cell loss, distribution and density of α-synuclein-immunoreactive LBs and duration of motor symptoms in 97 patients with PD. Density of pigmented neurons was measured in a single section of one half of the substantia nigra (SN) with delineation of the dorsal and ventral tiers whereas the cortical and nigral LB densities were determined using a morphometric approach. The density of nigral neurons was estimated to decrease by 2% each year after confirmation of the clinical diagnosis of PD but showed marked heterogeneity with some PD patients with longer duration of illness still possessing a significant number of preserved pigmented nigral neurons at the time of death. An average 15% of surviving nigral neurones contained LBs and the age-adjusted proportion of LB-bearing neurons appeared relatively stable throughout the disease duration. No difference was observed in the age at death or duration of disease with respect to Braak PD stages. The nigral neuronal density was unrelated to either the Braak PD stage or to cortical LB densities. We conclude that nigral neuronal loss is slow and shows considerable variation in PD. Our data also provides no support for a primary pathogenic role of LBs as neither their distribution nor density was associated with the severity of nigral cell loss. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/23939308/Disentangling_the_relationship_between_lewy_bodies_and_nigral_neuronal_loss_in_Parkinson's_disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JPD-2011-11046 DB - PRIME DP - Unbound Medicine ER -