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Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women.
Ann Rheum Dis 2014; 73(11):1949-53AR

Abstract

OBJECTIVES

To analyse the association between dietary long-chain n-3 polyunsaturated fatty acids (PUFAs) and incidence of rheumatoid arthritis (RA) in middle-aged and older women from the Swedish Mammography Cohort, a population-based prospective study.

METHODS

Data on diet were collected in 1987 and 1997 via a self-administered food-frequency questionnaire (FFQ). The risk of RA associated with dietary long-chain n-3 PUFAs and fish intake was estimated using Cox proportional hazard regression models, adjusted for age, cigarette smoking, alcohol intake, use of aspirin and energy intake.

RESULTS

Among 32 232 women born 1914-1948, 205 RA cases were identified during a mean follow-up of 7.5 years (1 January 2003 to 31 December 2010; 2 41 120 person-years). An intake of dietary long-chain n-3 PUFAs (FFQ1997) of more than 0.21 g/day (lowest quintile) was associated with a 35% decreased risk of developing RA (multivariable adjusted relative risk (RR) 0.65; 95% CI 0.48 to 0.90) compared with a lower intake. Long-term intake consistently higher than 0.21 g/day (according to both FFQ1987 and FFQ1997) was associated with a 52% (95% CI 29% to 67%) decreased risk. Consistent long-term consumption (FFQ1987 and FFQ1997) of fish ≥1 serving per week compared with<1 was associated with a 29% decrease in risk (RR 0.71; 95% CI 0.48 to 1.04).

CONCLUSIONS

This prospective study of women supports the hypothesis that dietary intake of long-chain n-3 PUFAs may play a role in aetiology of RA.

Authors+Show Affiliations

Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm, Sweden.Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23940215

Citation

Di Giuseppe, Daniela, et al. "Long-term Intake of Dietary Long-chain N-3 Polyunsaturated Fatty Acids and Risk of Rheumatoid Arthritis: a Prospective Cohort Study of Women." Annals of the Rheumatic Diseases, vol. 73, no. 11, 2014, pp. 1949-53.
Di Giuseppe D, Wallin A, Bottai M, et al. Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women. Ann Rheum Dis. 2014;73(11):1949-53.
Di Giuseppe, D., Wallin, A., Bottai, M., Askling, J., & Wolk, A. (2014). Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women. Annals of the Rheumatic Diseases, 73(11), pp. 1949-53. doi:10.1136/annrheumdis-2013-203338.
Di Giuseppe D, et al. Long-term Intake of Dietary Long-chain N-3 Polyunsaturated Fatty Acids and Risk of Rheumatoid Arthritis: a Prospective Cohort Study of Women. Ann Rheum Dis. 2014;73(11):1949-53. PubMed PMID: 23940215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women. AU - Di Giuseppe,Daniela, AU - Wallin,Alice, AU - Bottai,Matteo, AU - Askling,Johan, AU - Wolk,Alicja, Y1 - 2013/08/12/ PY - 2013/8/14/entrez PY - 2013/8/14/pubmed PY - 2014/12/15/medline KW - Arthritis KW - Epidemiology KW - Rheumatoid Arthritis SP - 1949 EP - 53 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 73 IS - 11 N2 - OBJECTIVES: To analyse the association between dietary long-chain n-3 polyunsaturated fatty acids (PUFAs) and incidence of rheumatoid arthritis (RA) in middle-aged and older women from the Swedish Mammography Cohort, a population-based prospective study. METHODS: Data on diet were collected in 1987 and 1997 via a self-administered food-frequency questionnaire (FFQ). The risk of RA associated with dietary long-chain n-3 PUFAs and fish intake was estimated using Cox proportional hazard regression models, adjusted for age, cigarette smoking, alcohol intake, use of aspirin and energy intake. RESULTS: Among 32 232 women born 1914-1948, 205 RA cases were identified during a mean follow-up of 7.5 years (1 January 2003 to 31 December 2010; 2 41 120 person-years). An intake of dietary long-chain n-3 PUFAs (FFQ1997) of more than 0.21 g/day (lowest quintile) was associated with a 35% decreased risk of developing RA (multivariable adjusted relative risk (RR) 0.65; 95% CI 0.48 to 0.90) compared with a lower intake. Long-term intake consistently higher than 0.21 g/day (according to both FFQ1987 and FFQ1997) was associated with a 52% (95% CI 29% to 67%) decreased risk. Consistent long-term consumption (FFQ1987 and FFQ1997) of fish ≥1 serving per week compared with<1 was associated with a 29% decrease in risk (RR 0.71; 95% CI 0.48 to 1.04). CONCLUSIONS: This prospective study of women supports the hypothesis that dietary intake of long-chain n-3 PUFAs may play a role in aetiology of RA. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/23940215/Long_term_intake_of_dietary_long_chain_n_3_polyunsaturated_fatty_acids_and_risk_of_rheumatoid_arthritis:_a_prospective_cohort_study_of_women_ L2 - http://ard.bmj.com/cgi/pmidlookup?view=long&amp;pmid=23940215 DB - PRIME DP - Unbound Medicine ER -