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The impact of roller compaction and tablet compression on physicomechanical properties of pharmaceutical excipients.
Pharm Dev Technol. 2014 Aug; 19(5):583-92.PD

Abstract

Material properties play a significant role in pharmaceutical processing. The impact of roller compaction (RC) and tablet compression on solid fraction (SF), tensile strength (TS) and flexural modulus (FM) of Avicel DG [co-processed excipient with 75% microcrystalline cellulose (MCC) and 25% anhydrous dibasic calcium phosphate (DCPA)], lactose and 1:1 Mixture of the two was studied. Materials were roller compacted at different force and roller type and compressed into tablets over a range of compression pressures (CP). SF, TS and FM were determined for ribbons and tablets. Roller force was a significant variable affecting SF while roller type was not. Both SF and TS of tablets increased with CP with Avicel DG exhibiting greater TS than that of 1:1 Mixture while tablets of lactose had the lowest TS. The TS of tablets decreased exponentially with tablet porosity. Ribbon of Avicel DG had higher TS and lower SF than lactose and greater reworkability. This is attributed to plastic deformation of MCC resulting in high degree of bonding and fragmentation of DCPA that fills the void spaces during tablet compression. The lack of significant increase in SF and low tablet TS for lactose upon compression is likely due to its brittle fragmentation and some elastic recovery as shown by the high FM.

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Authors+Show Affiliations

Iyer RM
Hoffmann-La Roche Inc., Pharmaceutical & Analytical R & D , Nutley , USA.
Hegde S
No affiliation info available
Dinunzio J
No affiliation info available
Singhal D
No affiliation info available
Malick W
No affiliation info available

MeSH

Calcium PhosphatesCelluloseDrug CompoundingExcipientsHardnessLactosePressureTabletsTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23941645

Citation

Iyer, Raman Mahadevan, et al. "The Impact of Roller Compaction and Tablet Compression On Physicomechanical Properties of Pharmaceutical Excipients." Pharmaceutical Development and Technology, vol. 19, no. 5, 2014, pp. 583-92.
Iyer RM, Hegde S, Dinunzio J, et al. The impact of roller compaction and tablet compression on physicomechanical properties of pharmaceutical excipients. Pharm Dev Technol. 2014;19(5):583-92.
Iyer, R. M., Hegde, S., Dinunzio, J., Singhal, D., & Malick, W. (2014). The impact of roller compaction and tablet compression on physicomechanical properties of pharmaceutical excipients. Pharmaceutical Development and Technology, 19(5), 583-92. https://doi.org/10.3109/10837450.2013.813541
Iyer RM, et al. The Impact of Roller Compaction and Tablet Compression On Physicomechanical Properties of Pharmaceutical Excipients. Pharm Dev Technol. 2014;19(5):583-92. PubMed PMID: 23941645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of roller compaction and tablet compression on physicomechanical properties of pharmaceutical excipients. AU - Iyer,Raman Mahadevan, AU - Hegde,Shridhar, AU - Dinunzio,James, AU - Singhal,Dharmendra, AU - Malick,Waseem, Y1 - 2013/08/14/ PY - 2013/8/15/entrez PY - 2013/8/15/pubmed PY - 2014/8/21/medline SP - 583 EP - 92 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 19 IS - 5 N2 - Material properties play a significant role in pharmaceutical processing. The impact of roller compaction (RC) and tablet compression on solid fraction (SF), tensile strength (TS) and flexural modulus (FM) of Avicel DG [co-processed excipient with 75% microcrystalline cellulose (MCC) and 25% anhydrous dibasic calcium phosphate (DCPA)], lactose and 1:1 Mixture of the two was studied. Materials were roller compacted at different force and roller type and compressed into tablets over a range of compression pressures (CP). SF, TS and FM were determined for ribbons and tablets. Roller force was a significant variable affecting SF while roller type was not. Both SF and TS of tablets increased with CP with Avicel DG exhibiting greater TS than that of 1:1 Mixture while tablets of lactose had the lowest TS. The TS of tablets decreased exponentially with tablet porosity. Ribbon of Avicel DG had higher TS and lower SF than lactose and greater reworkability. This is attributed to plastic deformation of MCC resulting in high degree of bonding and fragmentation of DCPA that fills the void spaces during tablet compression. The lack of significant increase in SF and low tablet TS for lactose upon compression is likely due to its brittle fragmentation and some elastic recovery as shown by the high FM. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/23941645/The_impact_of_roller_compaction_and_tablet_compression_on_physicomechanical_properties_of_pharmaceutical_excipients_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2013.813541 DB - PRIME DP - Unbound Medicine ER -