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Assessment of serum IGF-1 and adipokines related to metabolic dysfunction in HIV-infected adults.
Cytokine. 2013 Oct; 64(1):97-102.C

Abstract

PURPOSE

HIV/HAART associated metabolic syndrome (HAMS) seems to result from direct influence of HIV, adverse effects of combined antiretroviral therapy (cART) and individual genetic predisposition. This study aimed to assess the influence of HIV infection and cART on serum concentration of insulin-like growth factor-1 (IGF-1) and adipokines related to metabolic abnormalities.

METHODS

Seventy-two HIV infected patients including 48 HIV/HCV coinfected were enrolled in this study. Insulin resistance was evaluated by Homeostatic Model Assessment (HOMA) indexes. Serum concentrations of IGF-1, adiponectin, chemerin and visfatin were measured by ELISA.

RESULTS

Significant correlation between serum IGF-1 level and CD4 lymphocytes count was demonstrated and the lowest values were observed in subjects with CD4<200 cells/μL. Serum concentration of IGF-1 was significantly higher in patients treated with protease inhibitors based regimen compared to non-nucleoside reverse transcriptase inhibitors and healthy subjects. A significant negative correlation between serum concentration of adiponectin and waist-hip ratio as an indicator of central obesity, was found. There were significant positive correlations between serum concentration of chemerin and HOMA1-IR and serum IGF-1 concentration. Serum chemerin was increased in patients with insulin resistance vs. those with preserved insulin sensitivity.

CONCLUSIONS

According to these results HAMS is associated with insulin resistance and imbalance of adipokines serum concentration, therefore identification of pathways related to HAMS development might be helpful in management of the syndrome. Serum IGF-1 largely depends on level of immunodeficiency in HIV-infection and may provide a link between immune dysfunction and development of HIV-associated lipodystrophy, AIDS wasting syndrome, diabetes and/or cardiovascular diseases in HIV-infected patients.

Authors+Show Affiliations

Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Zurawia Str. 14, 15-540 Bialystok, Poland. Electronic address: anna.parfieniuk@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23941777

Citation

Parfieniuk-Kowerda, Anna, et al. "Assessment of Serum IGF-1 and Adipokines Related to Metabolic Dysfunction in HIV-infected Adults." Cytokine, vol. 64, no. 1, 2013, pp. 97-102.
Parfieniuk-Kowerda A, Czaban SL, Grzeszczuk A, et al. Assessment of serum IGF-1 and adipokines related to metabolic dysfunction in HIV-infected adults. Cytokine. 2013;64(1):97-102.
Parfieniuk-Kowerda, A., Czaban, S. L., Grzeszczuk, A., Jaroszewicz, J., & Flisiak, R. (2013). Assessment of serum IGF-1 and adipokines related to metabolic dysfunction in HIV-infected adults. Cytokine, 64(1), 97-102. https://doi.org/10.1016/j.cyto.2013.07.018
Parfieniuk-Kowerda A, et al. Assessment of Serum IGF-1 and Adipokines Related to Metabolic Dysfunction in HIV-infected Adults. Cytokine. 2013;64(1):97-102. PubMed PMID: 23941777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of serum IGF-1 and adipokines related to metabolic dysfunction in HIV-infected adults. AU - Parfieniuk-Kowerda,Anna, AU - Czaban,Sławomir Lech, AU - Grzeszczuk,Anna, AU - Jaroszewicz,Jerzy, AU - Flisiak,Robert, Y1 - 2013/08/12/ PY - 2013/02/01/received PY - 2013/07/11/revised PY - 2013/07/21/accepted PY - 2013/8/15/entrez PY - 2013/8/15/pubmed PY - 2014/4/16/medline KW - Adipokines KW - HCV KW - HIV KW - IGF-1 KW - cART SP - 97 EP - 102 JF - Cytokine JO - Cytokine VL - 64 IS - 1 N2 - PURPOSE: HIV/HAART associated metabolic syndrome (HAMS) seems to result from direct influence of HIV, adverse effects of combined antiretroviral therapy (cART) and individual genetic predisposition. This study aimed to assess the influence of HIV infection and cART on serum concentration of insulin-like growth factor-1 (IGF-1) and adipokines related to metabolic abnormalities. METHODS: Seventy-two HIV infected patients including 48 HIV/HCV coinfected were enrolled in this study. Insulin resistance was evaluated by Homeostatic Model Assessment (HOMA) indexes. Serum concentrations of IGF-1, adiponectin, chemerin and visfatin were measured by ELISA. RESULTS: Significant correlation between serum IGF-1 level and CD4 lymphocytes count was demonstrated and the lowest values were observed in subjects with CD4<200 cells/μL. Serum concentration of IGF-1 was significantly higher in patients treated with protease inhibitors based regimen compared to non-nucleoside reverse transcriptase inhibitors and healthy subjects. A significant negative correlation between serum concentration of adiponectin and waist-hip ratio as an indicator of central obesity, was found. There were significant positive correlations between serum concentration of chemerin and HOMA1-IR and serum IGF-1 concentration. Serum chemerin was increased in patients with insulin resistance vs. those with preserved insulin sensitivity. CONCLUSIONS: According to these results HAMS is associated with insulin resistance and imbalance of adipokines serum concentration, therefore identification of pathways related to HAMS development might be helpful in management of the syndrome. Serum IGF-1 largely depends on level of immunodeficiency in HIV-infection and may provide a link between immune dysfunction and development of HIV-associated lipodystrophy, AIDS wasting syndrome, diabetes and/or cardiovascular diseases in HIV-infected patients. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/23941777/Assessment_of_serum_IGF_1_and_adipokines_related_to_metabolic_dysfunction_in_HIV_infected_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(13)00633-9 DB - PRIME DP - Unbound Medicine ER -