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Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory fitness in postmenopausal women: a double-blind, randomized clinical pilot study.
Menopause. 2014 Apr; 21(4):376-82.M

Abstract

OBJECTIVE

The aim of this study was to evaluate the isolated and associated effects of oral estrogen therapy and aerobic training on cardiorespiratory fitness in postmenopausal women.

METHODS

Forty-two hysterectomized healthy postmenopausal women were randomly divided (in a double-blind manner) into four groups: placebo-control (n = 9), estrogen therapy-control (n = 12), placebo-aerobic training (PLA-AT; n = 11), and estrogen therapy-aerobic training (ET-AT; n = 10). The estrogen therapy groups received estradiol valerate (1 mg/day) and the aerobic training groups trained on a cycle ergometer three times per week at moderate intensity. Before and 6 months after the interventions, all women underwent a maximal cardiopulmonary exercise test on a cycle ergometer.

RESULTS

Regardless of hormone therapy, aerobic training increased oxygen uptake at anaerobic threshold (P = 0.001), oxygen uptake at respiratory compensation point (P = 0.043), and oxygen uptake at peak exercise (P = 0.020). The increases at respiratory compensation point and peak exercise were significantly greater in the groups receiving placebo than in the groups receiving estrogen (oxygen uptake at respiratory compensation point: PLA-AT +5.3 [2.8] vs ET-AT +3.0 [2.5] mL kg(-1) min(-1), P = 0.04; oxygen uptake at peak exercise: PLA-AT +5.8 [3.4] vs ET-AT +2.8 [1.4] mL kg(-1) min(-1), P = 0.02).

CONCLUSIONS

Oral estrogen therapy may mitigate the cardiorespiratory fitness increase induced by aerobic training in hysterectomized healthy postmenopausal women.

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Authors+Show Affiliations

Cardoso CG
From the 1Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil; 2Center for Sport and Physical Education, State University of Londrina, Londrina, Brazil; and 3Gynecology and Climacteric Service and 4Hypertension Unit, General Hospital, University of São Paulo, São Paulo, Brazil.
Medina FL
No affiliation info available
Pinto LG
No affiliation info available
Oneda B
No affiliation info available
Costa LA
No affiliation info available
Labes E
No affiliation info available
Abrahão SB
No affiliation info available
Tinucci T
No affiliation info available
Mion D
No affiliation info available
Fonseca AM
No affiliation info available
de Moraes Forjaz CL
No affiliation info available

MeSH

Double-Blind MethodEstradiolEstrogen Replacement TherapyExerciseExercise TestFemaleHeartHumansHysterectomyLungMiddle AgedOxygen ConsumptionPhysical FitnessPilot ProjectsPlacebosPostmenopause

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23942244

Citation

Cardoso, Crivaldo Gomes, et al. "Oral Estrogen Therapy May Mitigate the Effects of Aerobic Training On Cardiorespiratory Fitness in Postmenopausal Women: a Double-blind, Randomized Clinical Pilot Study." Menopause (New York, N.Y.), vol. 21, no. 4, 2014, pp. 376-82.
Cardoso CG, Medina FL, Pinto LG, et al. Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory fitness in postmenopausal women: a double-blind, randomized clinical pilot study. Menopause. 2014;21(4):376-82.
Cardoso, C. G., Medina, F. L., Pinto, L. G., Oneda, B., Costa, L. A., Labes, E., Abrahão, S. B., Tinucci, T., Mion, D., Fonseca, A. M., & de Moraes Forjaz, C. L. (2014). Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory fitness in postmenopausal women: a double-blind, randomized clinical pilot study. Menopause (New York, N.Y.), 21(4), 376-82. https://doi.org/10.1097/GME.0b013e31829e4a35
Cardoso CG, et al. Oral Estrogen Therapy May Mitigate the Effects of Aerobic Training On Cardiorespiratory Fitness in Postmenopausal Women: a Double-blind, Randomized Clinical Pilot Study. Menopause. 2014;21(4):376-82. PubMed PMID: 23942244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory fitness in postmenopausal women: a double-blind, randomized clinical pilot study. AU - Cardoso,Crivaldo Gomes,Jr AU - Medina,Fábio Leandro, AU - Pinto,Luiz Gustavo, AU - Oneda,Bruna, AU - Costa,Luiz Augusto Riani, AU - Labes,Eliana, AU - Abrahão,Sandra Baliero, AU - Tinucci,Taís, AU - Mion,Décio,Jr AU - Fonseca,Angela Maggio, AU - de Moraes Forjaz,Cláudia Luica, PY - 2013/8/15/entrez PY - 2013/8/15/pubmed PY - 2014/12/15/medline SP - 376 EP - 82 JF - Menopause (New York, N.Y.) JO - Menopause VL - 21 IS - 4 N2 - OBJECTIVE: The aim of this study was to evaluate the isolated and associated effects of oral estrogen therapy and aerobic training on cardiorespiratory fitness in postmenopausal women. METHODS: Forty-two hysterectomized healthy postmenopausal women were randomly divided (in a double-blind manner) into four groups: placebo-control (n = 9), estrogen therapy-control (n = 12), placebo-aerobic training (PLA-AT; n = 11), and estrogen therapy-aerobic training (ET-AT; n = 10). The estrogen therapy groups received estradiol valerate (1 mg/day) and the aerobic training groups trained on a cycle ergometer three times per week at moderate intensity. Before and 6 months after the interventions, all women underwent a maximal cardiopulmonary exercise test on a cycle ergometer. RESULTS: Regardless of hormone therapy, aerobic training increased oxygen uptake at anaerobic threshold (P = 0.001), oxygen uptake at respiratory compensation point (P = 0.043), and oxygen uptake at peak exercise (P = 0.020). The increases at respiratory compensation point and peak exercise were significantly greater in the groups receiving placebo than in the groups receiving estrogen (oxygen uptake at respiratory compensation point: PLA-AT +5.3 [2.8] vs ET-AT +3.0 [2.5] mL kg(-1) min(-1), P = 0.04; oxygen uptake at peak exercise: PLA-AT +5.8 [3.4] vs ET-AT +2.8 [1.4] mL kg(-1) min(-1), P = 0.02). CONCLUSIONS: Oral estrogen therapy may mitigate the cardiorespiratory fitness increase induced by aerobic training in hysterectomized healthy postmenopausal women. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/23942244/Oral_estrogen_therapy_may_mitigate_the_effects_of_aerobic_training_on_cardiorespiratory_fitness_in_postmenopausal_women:_a_double_blind_randomized_clinical_pilot_study_ L2 - https://doi.org/10.1097/GME.0b013e31829e4a35 DB - PRIME DP - Unbound Medicine ER -