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Inhibition of adenosine 3',5'-monophosphate phosphodiesterase by nicotinamide and its homologues in vitro.
Physiol Chem Phys. 1975; 7(2):125-32.PC

Abstract

Inhibition of cAMP phosphodiesterase from rat liver by nicotinamide and its homologues was studied. Among the several compounds tested, such agents as nicotinamide, N2-ethylnicotinamide, N2-methylnicotinamide, N,N-diethylnicotinamide, 3-acetylpyridine, methylnicotinate, and ethylnicotinate showed potent inhibition of cAMP phosphodiesterase, with an over 90% inhibition by 5 mM ethylnicotinate when cAMP was used as substrate at a 0.48 x 10(-7) M concentration. A comparison of the inhibitory curves of theophylline, papaverine, and ethylnicotinate on enzyme activity showed them to be approximately coincident. Furthermore, the plots with abscissa of equal increments per concentration of ethylnicotinate in the presence of theophylline or papaverine coincided with that in the absence of these agents.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

239431

Citation

Shimoyama, M, et al. "Inhibition of Adenosine 3',5'-monophosphate Phosphodiesterase By Nicotinamide and Its Homologues in Vitro." Physiological Chemistry and Physics, vol. 7, no. 2, 1975, pp. 125-32.
Shimoyama M, Kawai M, Nasu S, et al. Inhibition of adenosine 3',5'-monophosphate phosphodiesterase by nicotinamide and its homologues in vitro. Physiol Chem Phys. 1975;7(2):125-32.
Shimoyama, M., Kawai, M., Nasu, S., Shioji, K., & Hoshi, Y. (1975). Inhibition of adenosine 3',5'-monophosphate phosphodiesterase by nicotinamide and its homologues in vitro. Physiological Chemistry and Physics, 7(2), 125-32.
Shimoyama M, et al. Inhibition of Adenosine 3',5'-monophosphate Phosphodiesterase By Nicotinamide and Its Homologues in Vitro. Physiol Chem Phys. 1975;7(2):125-32. PubMed PMID: 239431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of adenosine 3',5'-monophosphate phosphodiesterase by nicotinamide and its homologues in vitro. AU - Shimoyama,M, AU - Kawai,M, AU - Nasu,S, AU - Shioji,K, AU - Hoshi,Y, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 125 EP - 32 JF - Physiological chemistry and physics JO - Physiol Chem Phys VL - 7 IS - 2 N2 - Inhibition of cAMP phosphodiesterase from rat liver by nicotinamide and its homologues was studied. Among the several compounds tested, such agents as nicotinamide, N2-ethylnicotinamide, N2-methylnicotinamide, N,N-diethylnicotinamide, 3-acetylpyridine, methylnicotinate, and ethylnicotinate showed potent inhibition of cAMP phosphodiesterase, with an over 90% inhibition by 5 mM ethylnicotinate when cAMP was used as substrate at a 0.48 x 10(-7) M concentration. A comparison of the inhibitory curves of theophylline, papaverine, and ethylnicotinate on enzyme activity showed them to be approximately coincident. Furthermore, the plots with abscissa of equal increments per concentration of ethylnicotinate in the presence of theophylline or papaverine coincided with that in the absence of these agents. SN - 0031-9325 UR - https://www.unboundmedicine.com/medline/citation/239431/Inhibition_of_adenosine_3'5'_monophosphate_phosphodiesterase_by_nicotinamide_and_its_homologues_in_vitro_ DB - PRIME DP - Unbound Medicine ER -