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Effect of carbacholine and urecholine on pentagastrin-stimulated gastric secretion in healthy subjects.
Scand J Gastroenterol. 1975; 10(4):357-62.SJ

Abstract

Dose-response studies of pentagastrin-stimulated gastric secretion were performed in 6 healthy volunteers. On different days pentagastrin was given in doses of 0.15, 1.5, and 15 mug/kg/hr either alone or in combination with carbacholine, 2 mug/kg/hr, or urecholine, 60 mug/kg/hr. Carbacholine and urecholine increased acid and pepsin secretion evoked by the lowest dose of pentagastrin while there was no augmentation at the highest dose. The dose of pentagastrin required to elicit half maximal acid output (Km) tended to decrease by simultaneous infusion of carbacholine or urecholine, suggesting that the cholinomimetics increased the sensitivity of the parietal cells to pentagastrin stimulation. Km for pentagastrin alone was higher than previously found in unoperated duodenal ulcer patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

239447

Citation

Roland, M, et al. "Effect of Carbacholine and Urecholine On Pentagastrin-stimulated Gastric Secretion in Healthy Subjects." Scandinavian Journal of Gastroenterology, vol. 10, no. 4, 1975, pp. 357-62.
Roland M, Berstad A, Liavåg I. Effect of carbacholine and urecholine on pentagastrin-stimulated gastric secretion in healthy subjects. Scand J Gastroenterol. 1975;10(4):357-62.
Roland, M., Berstad, A., & Liavåg, I. (1975). Effect of carbacholine and urecholine on pentagastrin-stimulated gastric secretion in healthy subjects. Scandinavian Journal of Gastroenterology, 10(4), 357-62.
Roland M, Berstad A, Liavåg I. Effect of Carbacholine and Urecholine On Pentagastrin-stimulated Gastric Secretion in Healthy Subjects. Scand J Gastroenterol. 1975;10(4):357-62. PubMed PMID: 239447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of carbacholine and urecholine on pentagastrin-stimulated gastric secretion in healthy subjects. AU - Roland,M, AU - Berstad,A, AU - Liavåg,I, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 357 EP - 62 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 10 IS - 4 N2 - Dose-response studies of pentagastrin-stimulated gastric secretion were performed in 6 healthy volunteers. On different days pentagastrin was given in doses of 0.15, 1.5, and 15 mug/kg/hr either alone or in combination with carbacholine, 2 mug/kg/hr, or urecholine, 60 mug/kg/hr. Carbacholine and urecholine increased acid and pepsin secretion evoked by the lowest dose of pentagastrin while there was no augmentation at the highest dose. The dose of pentagastrin required to elicit half maximal acid output (Km) tended to decrease by simultaneous infusion of carbacholine or urecholine, suggesting that the cholinomimetics increased the sensitivity of the parietal cells to pentagastrin stimulation. Km for pentagastrin alone was higher than previously found in unoperated duodenal ulcer patients. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/239447/Effect_of_carbacholine_and_urecholine_on_pentagastrin_stimulated_gastric_secretion_in_healthy_subjects_ DB - PRIME DP - Unbound Medicine ER -