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Oral contraceptives and risk of breast cancer.
Int J Cancer 1990; 46(3):366-73IJ

Abstract

A national population-based case-control study was conducted in New Zealand to assess the effects of hormonal contraception on breast-cancer risk. A total of 891 women aged 25 to 54 with a first diagnosis of breast cancer, and 1864 control subjects, randomly selected from the electoral rolls, were interviewed. The relative risk of breast cancer for women who had ever used oral contraceptives was 1.0 (95% confidence interval 0.82-1.3). There was no increase in risk with duration of use, even among women who had continued to use oral contraceptives for 14 or more years (relative risk = 1.1, 95% confidence interval 0.78-1.7). The risk of breast cancer was not increased by use of oral contraceptives for long periods before the first pregnancy or by starting use at a young age. Parity, age at menarche, family history of breast cancer, or history of benign breast disease did not modify the effect of oral contraceptives on breast-cancer risk. Relative risk estimates were slightly, although not significantly, increased during the first few years after starting oral contraception and in women under 35 years of age at diagnosis.

Authors+Show Affiliations

Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2394503

Citation

Paul, C, et al. "Oral Contraceptives and Risk of Breast Cancer." International Journal of Cancer, vol. 46, no. 3, 1990, pp. 366-73.
Paul C, Skegg DC, Spears GF. Oral contraceptives and risk of breast cancer. Int J Cancer. 1990;46(3):366-73.
Paul, C., Skegg, D. C., & Spears, G. F. (1990). Oral contraceptives and risk of breast cancer. International Journal of Cancer, 46(3), pp. 366-73.
Paul C, Skegg DC, Spears GF. Oral Contraceptives and Risk of Breast Cancer. Int J Cancer. 1990 Sep 15;46(3):366-73. PubMed PMID: 2394503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptives and risk of breast cancer. AU - Paul,C, AU - Skegg,D C, AU - Spears,G F, PY - 1990/9/15/pubmed PY - 1990/9/15/medline PY - 1990/9/15/entrez KW - Age Factors KW - Bias KW - Biology KW - Breast Cancer KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Control Groups KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Error Sources KW - Family Planning KW - Female Contraception KW - Fertility KW - Fertility Measurements KW - Measurement KW - Neoplasms KW - New Zealand KW - Oceania KW - Oral Contraceptives KW - Parity KW - Population KW - Population Characteristics KW - Population Dynamics KW - Pregnancy KW - Reproduction KW - Research Methodology KW - Risk Factors KW - Studies SP - 366 EP - 73 JF - International journal of cancer JO - Int. J. Cancer VL - 46 IS - 3 N2 - A national population-based case-control study was conducted in New Zealand to assess the effects of hormonal contraception on breast-cancer risk. A total of 891 women aged 25 to 54 with a first diagnosis of breast cancer, and 1864 control subjects, randomly selected from the electoral rolls, were interviewed. The relative risk of breast cancer for women who had ever used oral contraceptives was 1.0 (95% confidence interval 0.82-1.3). There was no increase in risk with duration of use, even among women who had continued to use oral contraceptives for 14 or more years (relative risk = 1.1, 95% confidence interval 0.78-1.7). The risk of breast cancer was not increased by use of oral contraceptives for long periods before the first pregnancy or by starting use at a young age. Parity, age at menarche, family history of breast cancer, or history of benign breast disease did not modify the effect of oral contraceptives on breast-cancer risk. Relative risk estimates were slightly, although not significantly, increased during the first few years after starting oral contraception and in women under 35 years of age at diagnosis. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/2394503/Oral_contraceptives_and_risk_of_breast_cancer_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1990&volume=46&issue=3&spage=366 DB - PRIME DP - Unbound Medicine ER -