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Consumption of low-fat dairy products may delay natural menopause.
J Nutr 2013; 143(10):1642-50JN

Abstract

Later menopause is a risk factor for breast and endometrial cancer, yet few studies have investigated dietary predictors of this potentially modifiable event. In particular, dairy contains hormones and growth factors that could potentially affect menopausal timing. We therefore assessed the association between regular consumption of dairy foods and related nutrients and age at natural menopause. We conducted a prospective analysis with up to 20 y of follow-up in 46,059 participants in the Nurses' Health Study who were premenopausal in 1980. We observed 30,816 events of natural menopause over 401,754 person-years. In the total population, the estimated mean age at natural menopause was 51.5 y for women who consumed no low-fat dairy and 51.5, 51.6, 51.7, and 51.8 y for women who consumed 0.1-1.0, 1.1-2.0, 2.1-3.0, and >3 servings of low-fat dairy daily, respectively. Premenopausal women <51 y of age consuming >3 servings of low-fat dairy per day were 14% less likely (HR: 0.86; 95% CI: 0.77, 0.96; P-trend < 0.0001) to report natural menopause in the next month relative to those consuming 0.1-1 servings/d. Similar results were obtained for skim milk (for >6 servings/wk vs. 0-1 servings/mo: HR: 0.93; 95% CI: 0.89, 0.97; P-trend < 0.0001) but not for total high-fat dairy or whole milk. Dairy foods were not associated with age at menopause among women ≥51 y of age. These findings support the growing body of literature on the hormonally active nature of milk and dairy foods.

Authors+Show Affiliations

Departments of Epidemiology, and.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23946341

Citation

Carwile, Jenny L., et al. "Consumption of Low-fat Dairy Products May Delay Natural Menopause." The Journal of Nutrition, vol. 143, no. 10, 2013, pp. 1642-50.
Carwile JL, Willett WC, Michels KB. Consumption of low-fat dairy products may delay natural menopause. J Nutr. 2013;143(10):1642-50.
Carwile, J. L., Willett, W. C., & Michels, K. B. (2013). Consumption of low-fat dairy products may delay natural menopause. The Journal of Nutrition, 143(10), pp. 1642-50. doi:10.3945/jn.113.179739.
Carwile JL, Willett WC, Michels KB. Consumption of Low-fat Dairy Products May Delay Natural Menopause. J Nutr. 2013;143(10):1642-50. PubMed PMID: 23946341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of low-fat dairy products may delay natural menopause. AU - Carwile,Jenny L, AU - Willett,Walter C, AU - Michels,Karin B, Y1 - 2013/08/14/ PY - 2013/8/16/entrez PY - 2013/8/16/pubmed PY - 2013/11/15/medline SP - 1642 EP - 50 JF - The Journal of nutrition JO - J. Nutr. VL - 143 IS - 10 N2 - Later menopause is a risk factor for breast and endometrial cancer, yet few studies have investigated dietary predictors of this potentially modifiable event. In particular, dairy contains hormones and growth factors that could potentially affect menopausal timing. We therefore assessed the association between regular consumption of dairy foods and related nutrients and age at natural menopause. We conducted a prospective analysis with up to 20 y of follow-up in 46,059 participants in the Nurses' Health Study who were premenopausal in 1980. We observed 30,816 events of natural menopause over 401,754 person-years. In the total population, the estimated mean age at natural menopause was 51.5 y for women who consumed no low-fat dairy and 51.5, 51.6, 51.7, and 51.8 y for women who consumed 0.1-1.0, 1.1-2.0, 2.1-3.0, and >3 servings of low-fat dairy daily, respectively. Premenopausal women <51 y of age consuming >3 servings of low-fat dairy per day were 14% less likely (HR: 0.86; 95% CI: 0.77, 0.96; P-trend < 0.0001) to report natural menopause in the next month relative to those consuming 0.1-1 servings/d. Similar results were obtained for skim milk (for >6 servings/wk vs. 0-1 servings/mo: HR: 0.93; 95% CI: 0.89, 0.97; P-trend < 0.0001) but not for total high-fat dairy or whole milk. Dairy foods were not associated with age at menopause among women ≥51 y of age. These findings support the growing body of literature on the hormonally active nature of milk and dairy foods. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/23946341/Consumption_of_low_fat_dairy_products_may_delay_natural_menopause_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.113.179739 DB - PRIME DP - Unbound Medicine ER -