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Early adolescent cortical thinning is related to better neuropsychological performance.
J Int Neuropsychol Soc. 2013 Oct; 19(9):962-70.JI

Abstract

Adolescence is characterized by significant neuromaturation, including extensive cortical thinning, particularly in frontal regions. The goal of this study was to examine the behavioral correlates of neurostructural development in early adolescence. Participants were 185 healthy 12- to 14-year-olds (44% female) recruited from local schools. Participants completed a comprehensive neuropsychological test battery and magnetic resonance imaging session. Cortical surface reconstruction and thickness estimates were performed via FreeSurfer. Age and cortical thickness were negatively correlated in 10 brain regions, 7 of which were in frontal areas (β = −.15 to −.25, ps ≤ .05). Hierarchical linear regressions examined the influence of cortical thickness on working memory, attention, verbal learning and memory, visuospatial functioning, spatial planning and problem solving, and inhibition, controlling for age and intracranial volume. Thinner parietal cortices predicted better performances on tests of verbal learning and memory, visuospatial functioning, and spatial planning and problem solving (β = −.14 to −.24, ps ≤ .05). Age, spanning from 12 to 14 years, accounted for up to 6% of cortical thickness, suggesting substantial thinning during early adolescence, with males showing more accelerated thinning than females between ages 12 and 14. For both males and females, thinner parietal association cortices corresponded with better neurocognitive functioning above and beyond age alone.

Authors+Show Affiliations

1 Department of Psychiatry, University of California San Diego, La Jolla, California.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23947395

Citation

Squeglia, Lindsay M., et al. "Early Adolescent Cortical Thinning Is Related to Better Neuropsychological Performance." Journal of the International Neuropsychological Society : JINS, vol. 19, no. 9, 2013, pp. 962-70.
Squeglia LM, Jacobus J, Sorg SF, et al. Early adolescent cortical thinning is related to better neuropsychological performance. J Int Neuropsychol Soc. 2013;19(9):962-70.
Squeglia, L. M., Jacobus, J., Sorg, S. F., Jernigan, T. L., & Tapert, S. F. (2013). Early adolescent cortical thinning is related to better neuropsychological performance. Journal of the International Neuropsychological Society : JINS, 19(9), 962-70. https://doi.org/10.1017/S1355617713000878
Squeglia LM, et al. Early Adolescent Cortical Thinning Is Related to Better Neuropsychological Performance. J Int Neuropsychol Soc. 2013;19(9):962-70. PubMed PMID: 23947395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early adolescent cortical thinning is related to better neuropsychological performance. AU - Squeglia,Lindsay M, AU - Jacobus,Joanna, AU - Sorg,Scott F, AU - Jernigan,Terry L, AU - Tapert,Susan F, Y1 - 2013/08/15/ PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2014/4/18/medline SP - 962 EP - 70 JF - Journal of the International Neuropsychological Society : JINS JO - J Int Neuropsychol Soc VL - 19 IS - 9 N2 - Adolescence is characterized by significant neuromaturation, including extensive cortical thinning, particularly in frontal regions. The goal of this study was to examine the behavioral correlates of neurostructural development in early adolescence. Participants were 185 healthy 12- to 14-year-olds (44% female) recruited from local schools. Participants completed a comprehensive neuropsychological test battery and magnetic resonance imaging session. Cortical surface reconstruction and thickness estimates were performed via FreeSurfer. Age and cortical thickness were negatively correlated in 10 brain regions, 7 of which were in frontal areas (β = −.15 to −.25, ps ≤ .05). Hierarchical linear regressions examined the influence of cortical thickness on working memory, attention, verbal learning and memory, visuospatial functioning, spatial planning and problem solving, and inhibition, controlling for age and intracranial volume. Thinner parietal cortices predicted better performances on tests of verbal learning and memory, visuospatial functioning, and spatial planning and problem solving (β = −.14 to −.24, ps ≤ .05). Age, spanning from 12 to 14 years, accounted for up to 6% of cortical thickness, suggesting substantial thinning during early adolescence, with males showing more accelerated thinning than females between ages 12 and 14. For both males and females, thinner parietal association cortices corresponded with better neurocognitive functioning above and beyond age alone. SN - 1469-7661 UR - https://www.unboundmedicine.com/medline/citation/23947395/Early_adolescent_cortical_thinning_is_related_to_better_neuropsychological_performance_ L2 - https://www.cambridge.org/core/product/identifier/S1355617713000878/type/journal_article DB - PRIME DP - Unbound Medicine ER -