Tags

Type your tag names separated by a space and hit enter

Prognostic association of HbA1c and fasting plasma glucose with reduced kidney function in subjects with and without diabetes mellitus. Results from a population-based cohort study from Germany.
Prev Med. 2013 Nov; 57(5):596-600.PM

Abstract

OBJECTIVE

To determine the risk for incident reduced kidney function (RKF) of subjects with pre-diabetes (impaired fasting glucose (IFG, 5.6-6.9 mmol/L)) or HbA1c-defined pre-diabetes (5.7%-6.4%) and to determine dose-response relationships of fasting glucose and HbA1c with RKF in subjects with manifest diabetes mellitus.

METHOD

In a German population-based cohort, recruited 2000-2002 with ages 50-74 years, log-binomial regression was used to estimate relative risks (RR) with 95% confidence intervals (95%CI) and restricted cubic splines to plot dose-response relationships.

RESULTS

During 8 years of follow-up, 678 of 3538 study participants developed primary RKF. Although RKF risk factor prevalences and RKF incidences were higher in subjects with pre-diabetes than in subjects with normal FPG and/or HbA1c levels, an increased risk did not persist after adjusting for established cardiovascular risk factors (RR(IFG): 0.97 (95% CI: 0.75-1.25) and RR(HbA1c-defined pre-diabetes): 1.03 (95% CI: 0.86-1.23)). In subjects with manifest diabetes, RKF risk increased linearly to a more than three-fold risk with increasing fasting glucose and HbA1c levels (at HbA1c>6.4%).

CONCLUSION

This study provides further evidence that pre-diabetes may not directly contribute to the development of kidney disease. Subjects with pre-diabetes might nevertheless profit from preventive efforts reducing their cardiovascular risk profile because cardiovascular and kidney disease share common risk factors.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. Electronic address: b.schoettker@dkfz.de.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23948106

Citation

Schöttker, B, et al. "Prognostic Association of HbA1c and Fasting Plasma Glucose With Reduced Kidney Function in Subjects With and Without Diabetes Mellitus. Results From a Population-based Cohort Study From Germany." Preventive Medicine, vol. 57, no. 5, 2013, pp. 596-600.
Schöttker B, Brenner H, Koenig W, et al. Prognostic association of HbA1c and fasting plasma glucose with reduced kidney function in subjects with and without diabetes mellitus. Results from a population-based cohort study from Germany. Prev Med. 2013;57(5):596-600.
Schöttker, B., Brenner, H., Koenig, W., Müller, H., & Rothenbacher, D. (2013). Prognostic association of HbA1c and fasting plasma glucose with reduced kidney function in subjects with and without diabetes mellitus. Results from a population-based cohort study from Germany. Preventive Medicine, 57(5), 596-600. https://doi.org/10.1016/j.ypmed.2013.08.002
Schöttker B, et al. Prognostic Association of HbA1c and Fasting Plasma Glucose With Reduced Kidney Function in Subjects With and Without Diabetes Mellitus. Results From a Population-based Cohort Study From Germany. Prev Med. 2013;57(5):596-600. PubMed PMID: 23948106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic association of HbA1c and fasting plasma glucose with reduced kidney function in subjects with and without diabetes mellitus. Results from a population-based cohort study from Germany. AU - Schöttker,B, AU - Brenner,H, AU - Koenig,W, AU - Müller,H, AU - Rothenbacher,D, Y1 - 2013/08/13/ PY - 2013/04/30/received PY - 2013/07/29/revised PY - 2013/08/03/accepted PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2014/6/13/medline KW - BMI KW - Blood glucose KW - CKD KW - Cohort study KW - Diabetes mellitus, type 2 KW - Epidemiology KW - FPG KW - HbA(1c) KW - IFG KW - IGT KW - Impaired fasting glucose KW - Impaired glucose tolerance KW - Kidney disease KW - OGTT KW - OR KW - Odds ratio KW - Prediabetes KW - RKF KW - RR KW - Relative risk KW - body mass index KW - chronic kidney disease KW - fasting plasma glucose KW - glycated hemoglobin A(1c) KW - oral glucose tolerance test KW - reduced kidney function SP - 596 EP - 600 JF - Preventive medicine JO - Prev Med VL - 57 IS - 5 N2 - OBJECTIVE: To determine the risk for incident reduced kidney function (RKF) of subjects with pre-diabetes (impaired fasting glucose (IFG, 5.6-6.9 mmol/L)) or HbA1c-defined pre-diabetes (5.7%-6.4%) and to determine dose-response relationships of fasting glucose and HbA1c with RKF in subjects with manifest diabetes mellitus. METHOD: In a German population-based cohort, recruited 2000-2002 with ages 50-74 years, log-binomial regression was used to estimate relative risks (RR) with 95% confidence intervals (95%CI) and restricted cubic splines to plot dose-response relationships. RESULTS: During 8 years of follow-up, 678 of 3538 study participants developed primary RKF. Although RKF risk factor prevalences and RKF incidences were higher in subjects with pre-diabetes than in subjects with normal FPG and/or HbA1c levels, an increased risk did not persist after adjusting for established cardiovascular risk factors (RR(IFG): 0.97 (95% CI: 0.75-1.25) and RR(HbA1c-defined pre-diabetes): 1.03 (95% CI: 0.86-1.23)). In subjects with manifest diabetes, RKF risk increased linearly to a more than three-fold risk with increasing fasting glucose and HbA1c levels (at HbA1c>6.4%). CONCLUSION: This study provides further evidence that pre-diabetes may not directly contribute to the development of kidney disease. Subjects with pre-diabetes might nevertheless profit from preventive efforts reducing their cardiovascular risk profile because cardiovascular and kidney disease share common risk factors. SN - 1096-0260 UR - https://www.unboundmedicine.com/medline/citation/23948106/Prognostic_association_of_HbA1c_and_fasting_plasma_glucose_with_reduced_kidney_function_in_subjects_with_and_without_diabetes_mellitus__Results_from_a_population_based_cohort_study_from_Germany_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(13)00278-8 DB - PRIME DP - Unbound Medicine ER -