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Effects of endocannabinoid and endovanilloid systems on aversive memory extinction.
Behav Brain Res. 2013 Nov 01; 256:101-7.BB

Abstract

In contextual fear conditioning animals have to integrate various elemental stimuli into a coherent representation of the condition and then associate context representation with punishment. Although several studies indicated the modulating role of endocannabinoid system (ECS) on the associative learning, ECS effect on contextual fear conditioning requires further investigations. The present study assessed the effects of the increased endocannabinoid anandamide (AEA) tone on acquisition, retrieval and extinction of the contextual fear conditioning. Given that AEA may bind to cannabinoid type 1 (CB1) receptors as well as to postsynaptic ionotropic Transient Receptor Potential Vanilloid type 1 (TRPV1) channels, particular attention was paid in determining how the increased AEA tone influenced fear responses. Furthermore, it was investigated how the ECS modulated the effects of stress-sensitization on fear response. Thus, mice submitted or not to a social defeat stress protocol were treated with drugs acting on ECS, CB1 receptors or TRPV1 channels and tested in a contextual fear conditioning whose conditioning, retrieval and extinction phases were analyzed. ECS activation influenced the extinction process and contrasted the stress effects on fear memory. Furthermore, CB1 receptor antagonist blocked and TRPV1 channel antagonist promoted short- and long-term extinction. The present study indicates that ECS controls the extinction of aversive memories in the contextual fear conditioning.

Authors+Show Affiliations

I.R.C.C.S. Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143, Rome, Italy; Department of Psychology, Faculty of Medicine and Psychology, University "Sapienza" of Rome, via dei Marsi 78, 00185, Rome, Italy. Electronic address: daniela.laricchiuta@uniroma1.it.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23948212

Citation

Laricchiuta, Daniela, et al. "Effects of Endocannabinoid and Endovanilloid Systems On Aversive Memory Extinction." Behavioural Brain Research, vol. 256, 2013, pp. 101-7.
Laricchiuta D, Centonze D, Petrosini L. Effects of endocannabinoid and endovanilloid systems on aversive memory extinction. Behav Brain Res. 2013;256:101-7.
Laricchiuta, D., Centonze, D., & Petrosini, L. (2013). Effects of endocannabinoid and endovanilloid systems on aversive memory extinction. Behavioural Brain Research, 256, 101-7. https://doi.org/10.1016/j.bbr.2013.08.010
Laricchiuta D, Centonze D, Petrosini L. Effects of Endocannabinoid and Endovanilloid Systems On Aversive Memory Extinction. Behav Brain Res. 2013 Nov 1;256:101-7. PubMed PMID: 23948212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of endocannabinoid and endovanilloid systems on aversive memory extinction. AU - Laricchiuta,Daniela, AU - Centonze,Diego, AU - Petrosini,Laura, Y1 - 2013/08/12/ PY - 2013/07/03/received PY - 2013/08/01/revised PY - 2013/08/05/accepted PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2014/12/19/medline KW - 2-AG KW - 2-arachidonyl-glycerol KW - AEA KW - CB(1) KW - CB(1) receptor KW - CS KW - Contextual fear conditioning KW - ECS KW - FAAH KW - Fear relief KW - LT KW - Mice KW - ST KW - TRPV1 KW - TRPV1 channel KW - US KW - VHL KW - anandamide KW - cannabinoid type 1 KW - conditioned stimulus KW - endocannabinoid system KW - fatty acid amide hydrolase KW - i.p. KW - intraperitoneally KW - long-term KW - postsynaptic ionotropic transient receptor potential vanilloid type 1 KW - short-term KW - unconditioned stimulus KW - vehicle SP - 101 EP - 7 JF - Behavioural brain research JO - Behav. Brain Res. VL - 256 N2 - In contextual fear conditioning animals have to integrate various elemental stimuli into a coherent representation of the condition and then associate context representation with punishment. Although several studies indicated the modulating role of endocannabinoid system (ECS) on the associative learning, ECS effect on contextual fear conditioning requires further investigations. The present study assessed the effects of the increased endocannabinoid anandamide (AEA) tone on acquisition, retrieval and extinction of the contextual fear conditioning. Given that AEA may bind to cannabinoid type 1 (CB1) receptors as well as to postsynaptic ionotropic Transient Receptor Potential Vanilloid type 1 (TRPV1) channels, particular attention was paid in determining how the increased AEA tone influenced fear responses. Furthermore, it was investigated how the ECS modulated the effects of stress-sensitization on fear response. Thus, mice submitted or not to a social defeat stress protocol were treated with drugs acting on ECS, CB1 receptors or TRPV1 channels and tested in a contextual fear conditioning whose conditioning, retrieval and extinction phases were analyzed. ECS activation influenced the extinction process and contrasted the stress effects on fear memory. Furthermore, CB1 receptor antagonist blocked and TRPV1 channel antagonist promoted short- and long-term extinction. The present study indicates that ECS controls the extinction of aversive memories in the contextual fear conditioning. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/23948212/Effects_of_endocannabinoid_and_endovanilloid_systems_on_aversive_memory_extinction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(13)00486-5 DB - PRIME DP - Unbound Medicine ER -