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Improving asthma during pregnancy with dietary antioxidants: the current evidence.

Abstract

The complication of asthma during pregnancy is associated with a number of poor outcomes for the mother and fetus. This may be partially driven by increased oxidative stress induced by the combination of asthma and pregnancy. Asthma is a chronic inflammatory disease of the airways associated with systemic inflammation and oxidative stress, which contributes to worsening asthma symptoms. Pregnancy alone also intensifies oxidative stress through the systemic generation of excess reactive oxidative species (ROS). Antioxidants combat the damaging effects of ROS; yet antioxidant defenses are reduced in asthma. Diet and nutrition have been postulated as potential factors to combat the damaging effects of asthma. In particular, dietary antioxidants may play a role in alleviating the heightened oxidative stress in asthma. Although there are some observational and interventional studies that have shown protective effects of antioxidants in asthma, assessment of antioxidants in pregnancy are limited and there are no antioxidant intervention studies in asthmatic pregnancies on asthma outcomes. The aims of this paper are to (i) review the relationships between oxidative stress and dietary antioxidants in adults with asthma and asthma during pregnancy, and (ii) provide the rationale for which dietary management strategies, specifically increased dietary antioxidants, might positively impact maternal asthma outcomes. Improving asthma control through a holistic antioxidant dietary approach might be valuable in reducing asthma exacerbations and improving asthma management during pregnancy, subsequently impacting perinatal health.

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  • Authors+Show Affiliations

    ,

    Robinson Institute, School of Paediatrics and Reproductive Health, Adelaide University, Lyell McEwin Hospital, Haydown Road, Elizabeth Vale, SA 5112, Australia.

    ,

    Source

    Nutrients 5:8 2013 Aug 14 pg 3212-34

    MeSH

    Antioxidants
    Asthma
    Diet
    Dietary Supplements
    Female
    Humans
    Oxidative Stress
    Pregnancy
    Pregnancy Complications
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    23948757

    Citation

    Grieger, Jessica A., et al. "Improving Asthma During Pregnancy With Dietary Antioxidants: the Current Evidence." Nutrients, vol. 5, no. 8, 2013, pp. 3212-34.
    Grieger JA, Wood LG, Clifton VL. Improving asthma during pregnancy with dietary antioxidants: the current evidence. Nutrients. 2013;5(8):3212-34.
    Grieger, J. A., Wood, L. G., & Clifton, V. L. (2013). Improving asthma during pregnancy with dietary antioxidants: the current evidence. Nutrients, 5(8), pp. 3212-34. doi:10.3390/nu5083212.
    Grieger JA, Wood LG, Clifton VL. Improving Asthma During Pregnancy With Dietary Antioxidants: the Current Evidence. Nutrients. 2013 Aug 14;5(8):3212-34. PubMed PMID: 23948757.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Improving asthma during pregnancy with dietary antioxidants: the current evidence. AU - Grieger,Jessica A, AU - Wood,Lisa G, AU - Clifton,Vicki L, Y1 - 2013/08/14/ PY - 2013/06/14/received PY - 2013/08/06/revised PY - 2013/08/07/accepted PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2014/2/26/medline SP - 3212 EP - 34 JF - Nutrients JO - Nutrients VL - 5 IS - 8 N2 - The complication of asthma during pregnancy is associated with a number of poor outcomes for the mother and fetus. This may be partially driven by increased oxidative stress induced by the combination of asthma and pregnancy. Asthma is a chronic inflammatory disease of the airways associated with systemic inflammation and oxidative stress, which contributes to worsening asthma symptoms. Pregnancy alone also intensifies oxidative stress through the systemic generation of excess reactive oxidative species (ROS). Antioxidants combat the damaging effects of ROS; yet antioxidant defenses are reduced in asthma. Diet and nutrition have been postulated as potential factors to combat the damaging effects of asthma. In particular, dietary antioxidants may play a role in alleviating the heightened oxidative stress in asthma. Although there are some observational and interventional studies that have shown protective effects of antioxidants in asthma, assessment of antioxidants in pregnancy are limited and there are no antioxidant intervention studies in asthmatic pregnancies on asthma outcomes. The aims of this paper are to (i) review the relationships between oxidative stress and dietary antioxidants in adults with asthma and asthma during pregnancy, and (ii) provide the rationale for which dietary management strategies, specifically increased dietary antioxidants, might positively impact maternal asthma outcomes. Improving asthma control through a holistic antioxidant dietary approach might be valuable in reducing asthma exacerbations and improving asthma management during pregnancy, subsequently impacting perinatal health. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/23948757/full_citation L2 - http://www.mdpi.com/resolver?pii=nu5083212 DB - PRIME DP - Unbound Medicine ER -