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Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort.
J Alzheimers Dis. 2014; 38(1):201-9.JA

Abstract

BACKGROUND

Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged.

OBJECTIVE

The aim of this study was to investigate the association of midlife and late-life body mass index (BMI) with late-life dementia/Alzheimer's disease (AD) and whether the association was independent of other obesity-related co-morbidities.

METHODS

The association between midlife BMI (mean age 50.2, SD 6.0) and late-life BMI (mean age 71.2, SD 4.0) and incident dementia later in life (mean age 75.7, SD 5.0) were investigated among 1,304 participants of the longitudinal population-based Cardiovascular risk factors, Aging and Dementia (CAIDE) study, conducted in Eastern Finland. The duration of follow-up was 26 years. The diagnosis of dementia was based on DSM-IV criteria and the probable and possible AD on the NINCDS-ADRDA criteria.

RESULTS

Higher midlife BMI was associated with higher risk of incident dementia (adjusted HR, 95% CI 1.07, 1.00-1.14). However, decrease in BMI from midlife to late-life was associated with higher risk of dementia (1.14, 1.03-1.25 for one-unit decrease) and AD (1.20, 1.09-1.33). High late-life BMI was associated with lower risk of AD (0.89, 0.81-0.98) but the association with dementia was less evident (0.94, 0.86-1.03).

CONCLUSION

Higher midlife BMI is related to higher risk of dementia and AD, independently of obesity-related risk factors and co-morbidities. Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD. These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition.

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Publisher Full Text

Authors+Show Affiliations

Tolppanen AM
Department of Neurology, University of Eastern Finland, P.O. Kuopio, Finland.
Ngandu T
No affiliation info available
Kåreholt I
No affiliation info available
Laatikainen T
No affiliation info available
Rusanen M
No affiliation info available
Soininen H
No affiliation info available
Kivipelto M
No affiliation info available

MeSH

Age of OnsetAgedAged, 80 and overAgingBody Mass IndexCohort StudiesCommunity Health PlanningDementiaFemaleHumansMaleObesityRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23948937

Citation

Tolppanen, Anna-Maija, et al. "Midlife and Late-life Body Mass Index and Late-life Dementia: Results From a Prospective Population-based Cohort." Journal of Alzheimer's Disease : JAD, vol. 38, no. 1, 2014, pp. 201-9.
Tolppanen AM, Ngandu T, Kåreholt I, et al. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. J Alzheimers Dis. 2014;38(1):201-9.
Tolppanen, A. M., Ngandu, T., Kåreholt, I., Laatikainen, T., Rusanen, M., Soininen, H., & Kivipelto, M. (2014). Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. Journal of Alzheimer's Disease : JAD, 38(1), 201-9. https://doi.org/10.3233/JAD-130698
Tolppanen AM, et al. Midlife and Late-life Body Mass Index and Late-life Dementia: Results From a Prospective Population-based Cohort. J Alzheimers Dis. 2014;38(1):201-9. PubMed PMID: 23948937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. AU - Tolppanen,Anna-Maija, AU - Ngandu,Tiia, AU - Kåreholt,Ingemar, AU - Laatikainen,Tiina, AU - Rusanen,Minna, AU - Soininen,Hilkka, AU - Kivipelto,Miia, PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2014/6/18/medline KW - Alzheimer's disease KW - body mass index KW - dementia KW - obesity SP - 201 EP - 9 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 38 IS - 1 N2 - BACKGROUND: Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged. OBJECTIVE: The aim of this study was to investigate the association of midlife and late-life body mass index (BMI) with late-life dementia/Alzheimer's disease (AD) and whether the association was independent of other obesity-related co-morbidities. METHODS: The association between midlife BMI (mean age 50.2, SD 6.0) and late-life BMI (mean age 71.2, SD 4.0) and incident dementia later in life (mean age 75.7, SD 5.0) were investigated among 1,304 participants of the longitudinal population-based Cardiovascular risk factors, Aging and Dementia (CAIDE) study, conducted in Eastern Finland. The duration of follow-up was 26 years. The diagnosis of dementia was based on DSM-IV criteria and the probable and possible AD on the NINCDS-ADRDA criteria. RESULTS: Higher midlife BMI was associated with higher risk of incident dementia (adjusted HR, 95% CI 1.07, 1.00-1.14). However, decrease in BMI from midlife to late-life was associated with higher risk of dementia (1.14, 1.03-1.25 for one-unit decrease) and AD (1.20, 1.09-1.33). High late-life BMI was associated with lower risk of AD (0.89, 0.81-0.98) but the association with dementia was less evident (0.94, 0.86-1.03). CONCLUSION: Higher midlife BMI is related to higher risk of dementia and AD, independently of obesity-related risk factors and co-morbidities. Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD. These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/23948937/Midlife_and_late_life_body_mass_index_and_late_life_dementia:_results_from_a_prospective_population_based_cohort_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-130698 DB - PRIME DP - Unbound Medicine ER -