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Role of serum cholesterol in Parkinson's disease: a meta-analysis of evidence.
J Parkinsons Dis. 2013 Jan 01; 3(3):363-70.JP

Abstract

BACKGROUND

Results from several epidemiological studies found a potential role of cholesterol metabolism in Parkinson's disease (PD) pathogenesis. Further several studies assessed relation between dietary intake of cholesterol and risk of PD, although these studies showed varied results but give a clue of association between serum cholesterol and PD.

OBJECTIVE

We therefore examined the association between serum cholesterol and risk of PD.

METHODS

PubMed database and bibliographies of retrieved articles were searched for observational studies (published up to January 2013) investigating the relationship between serum cholesterol and PD. Pooled risk ratio (RR) was calculated using random-effects model. Subgroup, sensitivity analysis and publication bias were also done.

RESULTS

Eight relevant studies were identified, consisting of 4 each case-control and cohort studies involving a total of 246,112 subjects including 5,488 PD cases. Because of significant heterogeneity (P(heterogeneity) < 0.001, I2 = 70.34%) was observed, a random-effects model was chosen over a fixed-effects model. A combined analysis of 8 studies found no significant association between serum cholesterol and risk of PD (RR 0.87, 95% CI 0.67-1.13; p = 0.41).

CONCLUSIONS

We observed no probable association between serum cholesterol and risk of PD.

Authors+Show Affiliations

Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

23948990

Citation

Gudala, Kapil, et al. "Role of Serum Cholesterol in Parkinson's Disease: a Meta-analysis of Evidence." Journal of Parkinson's Disease, vol. 3, no. 3, 2013, pp. 363-70.
Gudala K, Bansal D, Muthyala H. Role of serum cholesterol in Parkinson's disease: a meta-analysis of evidence. J Parkinsons Dis. 2013;3(3):363-70.
Gudala, K., Bansal, D., & Muthyala, H. (2013). Role of serum cholesterol in Parkinson's disease: a meta-analysis of evidence. Journal of Parkinson's Disease, 3(3), 363-70. https://doi.org/10.3233/JPD-130196
Gudala K, Bansal D, Muthyala H. Role of Serum Cholesterol in Parkinson's Disease: a Meta-analysis of Evidence. J Parkinsons Dis. 2013 Jan 1;3(3):363-70. PubMed PMID: 23948990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of serum cholesterol in Parkinson's disease: a meta-analysis of evidence. AU - Gudala,Kapil, AU - Bansal,Dipika, AU - Muthyala,Harini, PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2014/6/18/medline SP - 363 EP - 70 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 3 IS - 3 N2 - BACKGROUND: Results from several epidemiological studies found a potential role of cholesterol metabolism in Parkinson's disease (PD) pathogenesis. Further several studies assessed relation between dietary intake of cholesterol and risk of PD, although these studies showed varied results but give a clue of association between serum cholesterol and PD. OBJECTIVE: We therefore examined the association between serum cholesterol and risk of PD. METHODS: PubMed database and bibliographies of retrieved articles were searched for observational studies (published up to January 2013) investigating the relationship between serum cholesterol and PD. Pooled risk ratio (RR) was calculated using random-effects model. Subgroup, sensitivity analysis and publication bias were also done. RESULTS: Eight relevant studies were identified, consisting of 4 each case-control and cohort studies involving a total of 246,112 subjects including 5,488 PD cases. Because of significant heterogeneity (P(heterogeneity) < 0.001, I2 = 70.34%) was observed, a random-effects model was chosen over a fixed-effects model. A combined analysis of 8 studies found no significant association between serum cholesterol and risk of PD (RR 0.87, 95% CI 0.67-1.13; p = 0.41). CONCLUSIONS: We observed no probable association between serum cholesterol and risk of PD. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/23948990/Role_of_serum_cholesterol_in_Parkinson's_disease:_a_meta_analysis_of_evidence_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JPD-130196 DB - PRIME DP - Unbound Medicine ER -