Abstract
BACKGROUND
Results from several epidemiological studies found a potential role of cholesterol metabolism in Parkinson's disease (PD) pathogenesis. Further several studies assessed relation between dietary intake of cholesterol and risk of PD, although these studies showed varied results but give a clue of association between serum cholesterol and PD.
OBJECTIVE
We therefore examined the association between serum cholesterol and risk of PD.
METHODS
PubMed database and bibliographies of retrieved articles were searched for observational studies (published up to January 2013) investigating the relationship between serum cholesterol and PD. Pooled risk ratio (RR) was calculated using random-effects model. Subgroup, sensitivity analysis and publication bias were also done.
RESULTS
Eight relevant studies were identified, consisting of 4 each case-control and cohort studies involving a total of 246,112 subjects including 5,488 PD cases. Because of significant heterogeneity (P(heterogeneity) < 0.001, I2 = 70.34%) was observed, a random-effects model was chosen over a fixed-effects model. A combined analysis of 8 studies found no significant association between serum cholesterol and risk of PD (RR 0.87, 95% CI 0.67-1.13; p = 0.41).
CONCLUSIONS
We observed no probable association between serum cholesterol and risk of PD.
TY - JOUR
T1 - Role of serum cholesterol in Parkinson's disease: a meta-analysis of evidence.
AU - Gudala,Kapil,
AU - Bansal,Dipika,
AU - Muthyala,Harini,
PY - 2013/8/17/entrez
PY - 2013/8/21/pubmed
PY - 2014/6/18/medline
SP - 363
EP - 70
JF - Journal of Parkinson's disease
JO - J Parkinsons Dis
VL - 3
IS - 3
N2 - BACKGROUND: Results from several epidemiological studies found a potential role of cholesterol metabolism in Parkinson's disease (PD) pathogenesis. Further several studies assessed relation between dietary intake of cholesterol and risk of PD, although these studies showed varied results but give a clue of association between serum cholesterol and PD. OBJECTIVE: We therefore examined the association between serum cholesterol and risk of PD. METHODS: PubMed database and bibliographies of retrieved articles were searched for observational studies (published up to January 2013) investigating the relationship between serum cholesterol and PD. Pooled risk ratio (RR) was calculated using random-effects model. Subgroup, sensitivity analysis and publication bias were also done. RESULTS: Eight relevant studies were identified, consisting of 4 each case-control and cohort studies involving a total of 246,112 subjects including 5,488 PD cases. Because of significant heterogeneity (P(heterogeneity) < 0.001, I2 = 70.34%) was observed, a random-effects model was chosen over a fixed-effects model. A combined analysis of 8 studies found no significant association between serum cholesterol and risk of PD (RR 0.87, 95% CI 0.67-1.13; p = 0.41). CONCLUSIONS: We observed no probable association between serum cholesterol and risk of PD.
SN - 1877-718X
UR - https://www.unboundmedicine.com/medline/citation/23948990/Role_of_serum_cholesterol_in_Parkinson's_disease:_a_meta_analysis_of_evidence_
L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JPD-130196
DB - PRIME
DP - Unbound Medicine
ER -
