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The Healthy Eating Index 2005 and risk for pancreatic cancer in the NIH-AARP study.

Abstract

BACKGROUND

Dietary pattern analyses characterizing combinations of food intakes offer conceptual and statistical advantages over food- and nutrient-based analyses of disease risk. However, few studies have examined dietary patterns and pancreatic cancer risk and none focused on the 2005 Dietary Guidelines for Americans. We used the Healthy Eating Index 2005 (HEI-2005) to estimate the association between meeting those dietary guidelines and pancreatic cancer risk.

METHODS

We calculated the HEI-2005 score for 537 218 men and women in the National Institutes of Health-American Association of Retired Persons Diet and Health Study using responses to food frequency questionnaires returned in 1995 and 1996. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of pancreatic cancer according to HEI-2005 quintiles and explored effect modification by known risk factors. P interaction values were calculated using the Wald test. All statistical tests were two-sided.

RESULTS

We identified 2383 incident, exocrine pancreatic cancer cases (median = 10.5 years follow-up). Comparing participants who met the most dietary guidelines (Q5) with those who met the fewest guidelines (Q1), we observed a reduced risk of pancreatic cancer (HR = 0.85, 95% CI = 0.74 to 0.97). Among men there was an interaction by body mass index (P interaction = .03), with a hazard ratio of 0.72 (95% CI = 0.59 to 0.88) comparing Q5 vs Q1 in overweight/obese men (body mass index ≥ 25 kg/m(2)) but no association among normal weight men.

CONCLUSIONS

Our findings support the hypothesis that consuming a high-quality diet, as scored by the HEI-2005, may reduce the risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Yale School of Public Health, New Haven, CT , USA. Aremhe2@mail.nih.gov

    , , , , , ,

    Source

    Journal of the National Cancer Institute 105:17 2013 Sep 04 pg 1298-305

    MeSH

    Aged
    Aged, 80 and over
    Body Mass Index
    Diet Surveys
    Feeding Behavior
    Female
    Humans
    Incidence
    Linear Models
    Male
    Middle Aged
    Obesity
    Odds Ratio
    Overweight
    Pancreatic Neoplasms
    Proportional Hazards Models
    Research Design
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    23949329

    Citation

    Arem, Hannah, et al. "The Healthy Eating Index 2005 and Risk for Pancreatic Cancer in the NIH-AARP Study." Journal of the National Cancer Institute, vol. 105, no. 17, 2013, pp. 1298-305.
    Arem H, Reedy J, Sampson J, et al. The Healthy Eating Index 2005 and risk for pancreatic cancer in the NIH-AARP study. J Natl Cancer Inst. 2013;105(17):1298-305.
    Arem, H., Reedy, J., Sampson, J., Jiao, L., Hollenbeck, A. R., Risch, H., ... Stolzenberg-Solomon, R. Z. (2013). The Healthy Eating Index 2005 and risk for pancreatic cancer in the NIH-AARP study. Journal of the National Cancer Institute, 105(17), pp. 1298-305. doi:10.1093/jnci/djt185.
    Arem H, et al. The Healthy Eating Index 2005 and Risk for Pancreatic Cancer in the NIH-AARP Study. J Natl Cancer Inst. 2013 Sep 4;105(17):1298-305. PubMed PMID: 23949329.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Healthy Eating Index 2005 and risk for pancreatic cancer in the NIH-AARP study. AU - Arem,Hannah, AU - Reedy,Jill, AU - Sampson,Josh, AU - Jiao,Li, AU - Hollenbeck,Albert R, AU - Risch,Harvey, AU - Mayne,Susan T, AU - Stolzenberg-Solomon,Rachael Z, Y1 - 2013/08/15/ PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2013/11/5/medline SP - 1298 EP - 305 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 105 IS - 17 N2 - BACKGROUND: Dietary pattern analyses characterizing combinations of food intakes offer conceptual and statistical advantages over food- and nutrient-based analyses of disease risk. However, few studies have examined dietary patterns and pancreatic cancer risk and none focused on the 2005 Dietary Guidelines for Americans. We used the Healthy Eating Index 2005 (HEI-2005) to estimate the association between meeting those dietary guidelines and pancreatic cancer risk. METHODS: We calculated the HEI-2005 score for 537 218 men and women in the National Institutes of Health-American Association of Retired Persons Diet and Health Study using responses to food frequency questionnaires returned in 1995 and 1996. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of pancreatic cancer according to HEI-2005 quintiles and explored effect modification by known risk factors. P interaction values were calculated using the Wald test. All statistical tests were two-sided. RESULTS: We identified 2383 incident, exocrine pancreatic cancer cases (median = 10.5 years follow-up). Comparing participants who met the most dietary guidelines (Q5) with those who met the fewest guidelines (Q1), we observed a reduced risk of pancreatic cancer (HR = 0.85, 95% CI = 0.74 to 0.97). Among men there was an interaction by body mass index (P interaction = .03), with a hazard ratio of 0.72 (95% CI = 0.59 to 0.88) comparing Q5 vs Q1 in overweight/obese men (body mass index ≥ 25 kg/m(2)) but no association among normal weight men. CONCLUSIONS: Our findings support the hypothesis that consuming a high-quality diet, as scored by the HEI-2005, may reduce the risk of pancreatic cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/23949329/The_Healthy_Eating_Index_2005_and_risk_for_pancreatic_cancer_in_the_NIH_AARP_study_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djt185 DB - PRIME DP - Unbound Medicine ER -