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Increased serum oxidative stress markers in women with uterine leiomyoma.
PLoS One 2013; 8(8):e72069Plos

Abstract

BACKGROUND

Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma.

METHODOLOGY/PRINCIPAL FINDINGS

We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the abdominopelvic cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p<0.001, respectively). By contrast, serum thiol levels were lower in leiomyoma patients (p<0.001). We found positive correlations between serum AOPP concentrations and total fibroids weight (r=0.339; p=0.028), serum AOPP and serum protein carbonyls with duration of infertility (r=0.762; p=0.006 and r=0.683; p=0.021, respectively).

CONCLUSIONS/SIGNIFICANCE

This study, for the first time, reveals a significant increase of protein oxidative stress status and reduced antioxidant capacity in sera from women with uterine leiomyoma.

Authors+Show Affiliations

Université Paris Descartes, Sorbonne Paris Cité,Faculté de Médecine, AP- HP, Hôpital Cochin, Department of GynecologyObstetrics II and Reproductive Medicine,75679 Paris, France. pietro.santulli@cch.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23951284

Citation

Santulli, Pietro, et al. "Increased Serum Oxidative Stress Markers in Women With Uterine Leiomyoma." PloS One, vol. 8, no. 8, 2013, pp. e72069.
Santulli P, Borghese B, Lemaréchal H, et al. Increased serum oxidative stress markers in women with uterine leiomyoma. PLoS ONE. 2013;8(8):e72069.
Santulli, P., Borghese, B., Lemaréchal, H., Leconte, M., Millischer, A. E., Batteux, F., ... Borderie, D. (2013). Increased serum oxidative stress markers in women with uterine leiomyoma. PloS One, 8(8), pp. e72069. doi:10.1371/journal.pone.0072069.
Santulli P, et al. Increased Serum Oxidative Stress Markers in Women With Uterine Leiomyoma. PLoS ONE. 2013;8(8):e72069. PubMed PMID: 23951284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased serum oxidative stress markers in women with uterine leiomyoma. AU - Santulli,Pietro, AU - Borghese,Bruno, AU - Lemaréchal,Herve, AU - Leconte,Mahaut, AU - Millischer,Anne-Elodie, AU - Batteux,Frédéric, AU - Chapron,Charles, AU - Borderie,Didier, Y1 - 2013/08/09/ PY - 2013/02/09/received PY - 2013/07/10/accepted PY - 2013/8/17/entrez PY - 2013/8/21/pubmed PY - 2014/3/4/medline SP - e72069 EP - e72069 JF - PloS one JO - PLoS ONE VL - 8 IS - 8 N2 - BACKGROUND: Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven uterine leiomyoma. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a laboratory study in a tertiary-care university hospital. Fifty-nine women with histologically proven uterine leiomyoma and ninety-two leiomyoma-free control women have been enrolled in this study. Complete surgical exploration of the abdominopelvic cavity was performed in each patient. Preoperative serum samples were obtained from all study participants to assay serum thiols, AOPP, protein carbonyls and nitrates/nitrites. Concentrations of serum protein carbonyl groups and AOPP were higher in leiomyoma patients than in the control group (p=0.005 and p<0.001, respectively). By contrast, serum thiol levels were lower in leiomyoma patients (p<0.001). We found positive correlations between serum AOPP concentrations and total fibroids weight (r=0.339; p=0.028), serum AOPP and serum protein carbonyls with duration of infertility (r=0.762; p=0.006 and r=0.683; p=0.021, respectively). CONCLUSIONS/SIGNIFICANCE: This study, for the first time, reveals a significant increase of protein oxidative stress status and reduced antioxidant capacity in sera from women with uterine leiomyoma. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23951284/Increased_serum_oxidative_stress_markers_in_women_with_uterine_leiomyoma_ L2 - http://dx.plos.org/10.1371/journal.pone.0072069 DB - PRIME DP - Unbound Medicine ER -