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Modulation of human postprandial lipemia by changing ratios of polyunsaturated to saturated (P/S) fatty acid content of blended dietary fats: a cross-over design with repeated measures.
Nutr J. 2013 Aug 16; 12:122.NJ

Abstract

BACKGROUND

Postprandial lipemia (PL) contributes to coronary artery disease. The fatty acid composition of dietary fats is potentially a modifiable factor in modulating PL response.

METHODS

This human postprandial study evaluated 3 edible fat blends with differing polyunsaturated to saturated fatty acids (P/S) ratios (POL = 0.27, AHA = 1.00, PCAN = 1.32). A cross-over design included mildly hypercholestrolemic subjects (9 men and 6 women) preconditioned on test diets fats at 31% energy for 7 days prior to the postprandial challenge on the 8th day with 50 g test fat. Plasma lipids and lipoproteins were monitored at 0, 1.5, 3.5, 5.5 and 7 hr.

RESULTS

Plasma triacylglycerol (TAG) concentrations in response to POL, AHA or PCAN meals were not significant for time x test meal interactions (P > 0.05) despite an observed trend (POL > AHA > PCAN). TAG area-under-the-curve (AUC) increased by 22.58% after POL and 7.63% after PCAN compared to AHA treatments (P > 0.05). Plasma total cholesterol (TC) response was not significant between meals (P > 0.05). Varying P/S ratios of test meals significantly altered prandial high density lipoprotein-cholesterol (HDL-C) concentrations (P < 0.001) which increased with decreasing P/S ratio (POL > AHA > PCAN). Paired comparisons was significant between POL vs PCAN (P = 0.009) but not with AHA or between AHA vs PCAN (P > 0.05). A significantly higher HDL-C AUC for POL vs AHA (P = 0.015) and PCAN (P = 0.001) was observed. HDL-C AUC increased for POL by 25.38% and 16.0% compared to PCAN and AHA respectively. Plasma low density lipoprotein-cholesterol (LDL-C) concentrations was significant (P = 0.005) between meals and significantly lowest after POL meal compared to PCAN (P = 0.004) and AHA (P > 0.05) but not between AHA vs PCAN (P > 0.05). AUC for LDL-C was not significant between diets (P > 0.05). Palmitic (C16:0), oleic (C18:1), linoleic (C18:2) and linolenic (C18:3) acids in TAGs and cholesteryl esters were significantly modulated by meal source (P < 0.05).

CONCLUSIONS

P/S ratio of dietary fats significantly affected prandial HDL-C levels without affecting lipemia.

Authors+Show Affiliations

Faculty of Health Sciences, National University of Malaysia, Kuala Lumpur, Malaysia. kalyana@mpoc.org.my.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23953645

Citation

Karupaiah, Tilakavati, and Kalyana Sundram. "Modulation of Human Postprandial Lipemia By Changing Ratios of Polyunsaturated to Saturated (P/S) Fatty Acid Content of Blended Dietary Fats: a Cross-over Design With Repeated Measures." Nutrition Journal, vol. 12, 2013, p. 122.
Karupaiah T, Sundram K. Modulation of human postprandial lipemia by changing ratios of polyunsaturated to saturated (P/S) fatty acid content of blended dietary fats: a cross-over design with repeated measures. Nutr J. 2013;12:122.
Karupaiah, T., & Sundram, K. (2013). Modulation of human postprandial lipemia by changing ratios of polyunsaturated to saturated (P/S) fatty acid content of blended dietary fats: a cross-over design with repeated measures. Nutrition Journal, 12, 122. https://doi.org/10.1186/1475-2891-12-122
Karupaiah T, Sundram K. Modulation of Human Postprandial Lipemia By Changing Ratios of Polyunsaturated to Saturated (P/S) Fatty Acid Content of Blended Dietary Fats: a Cross-over Design With Repeated Measures. Nutr J. 2013 Aug 16;12:122. PubMed PMID: 23953645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of human postprandial lipemia by changing ratios of polyunsaturated to saturated (P/S) fatty acid content of blended dietary fats: a cross-over design with repeated measures. AU - Karupaiah,Tilakavati, AU - Sundram,Kalyana, Y1 - 2013/08/16/ PY - 2013/01/17/received PY - 2013/08/12/accepted PY - 2013/8/20/entrez PY - 2013/8/21/pubmed PY - 2014/1/17/medline SP - 122 EP - 122 JF - Nutrition journal JO - Nutr J VL - 12 N2 - BACKGROUND: Postprandial lipemia (PL) contributes to coronary artery disease. The fatty acid composition of dietary fats is potentially a modifiable factor in modulating PL response. METHODS: This human postprandial study evaluated 3 edible fat blends with differing polyunsaturated to saturated fatty acids (P/S) ratios (POL = 0.27, AHA = 1.00, PCAN = 1.32). A cross-over design included mildly hypercholestrolemic subjects (9 men and 6 women) preconditioned on test diets fats at 31% energy for 7 days prior to the postprandial challenge on the 8th day with 50 g test fat. Plasma lipids and lipoproteins were monitored at 0, 1.5, 3.5, 5.5 and 7 hr. RESULTS: Plasma triacylglycerol (TAG) concentrations in response to POL, AHA or PCAN meals were not significant for time x test meal interactions (P > 0.05) despite an observed trend (POL > AHA > PCAN). TAG area-under-the-curve (AUC) increased by 22.58% after POL and 7.63% after PCAN compared to AHA treatments (P > 0.05). Plasma total cholesterol (TC) response was not significant between meals (P > 0.05). Varying P/S ratios of test meals significantly altered prandial high density lipoprotein-cholesterol (HDL-C) concentrations (P < 0.001) which increased with decreasing P/S ratio (POL > AHA > PCAN). Paired comparisons was significant between POL vs PCAN (P = 0.009) but not with AHA or between AHA vs PCAN (P > 0.05). A significantly higher HDL-C AUC for POL vs AHA (P = 0.015) and PCAN (P = 0.001) was observed. HDL-C AUC increased for POL by 25.38% and 16.0% compared to PCAN and AHA respectively. Plasma low density lipoprotein-cholesterol (LDL-C) concentrations was significant (P = 0.005) between meals and significantly lowest after POL meal compared to PCAN (P = 0.004) and AHA (P > 0.05) but not between AHA vs PCAN (P > 0.05). AUC for LDL-C was not significant between diets (P > 0.05). Palmitic (C16:0), oleic (C18:1), linoleic (C18:2) and linolenic (C18:3) acids in TAGs and cholesteryl esters were significantly modulated by meal source (P < 0.05). CONCLUSIONS: P/S ratio of dietary fats significantly affected prandial HDL-C levels without affecting lipemia. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/23953645/Modulation_of_human_postprandial_lipemia_by_changing_ratios_of_polyunsaturated_to_saturated__P/S__fatty_acid_content_of_blended_dietary_fats:_a_cross_over_design_with_repeated_measures_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-122 DB - PRIME DP - Unbound Medicine ER -