Tags

Type your tag names separated by a space and hit enter

Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism.
Semin Nephrol. 2013 May; 33(3):265-76.SN

Abstract

The identification of primary aldosteronism as a common cause of resistant hypertension is a significant advance in our ability to care for patients with hypertension. Primary aldosteronism is common, and when unrecognized is associated with an increased incidence of adverse cardiovascular outcomes. Identification of primary aldosteronism is based on use of the plasma aldosterone level, plasma renin activity, and the aldosterone:renin ratio. Differentiation between unilateral and bilateral autonomous adrenal aldosterone production then guides further therapy, with use of mineralocorticoid-receptor blockers for patients with bilateral autonomous adrenal aldosterone production and laparoscopic adrenalectomy for patients with unilateral autonomous aldosterone production. In this review, we discuss in detail the pathogenesis of primary aldosteronism-induced hypertension and potassium disorders, the evaluation of the patient with suspected primary aldosteronism, and the management of primary aldosteronism, both through medications and surgery.

Authors+Show Affiliations

Nephrology and Hypertension Section, North Florida/South Georgia Veterans Health System, Gainesville, FL 32608, USA. david.weiner@medicine.ufl.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

23953804

Citation

Weiner, I David. "Endocrine and Hypertensive Disorders of Potassium Regulation: Primary Aldosteronism." Seminars in Nephrology, vol. 33, no. 3, 2013, pp. 265-76.
Weiner ID. Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism. Semin Nephrol. 2013;33(3):265-76.
Weiner, I. D. (2013). Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism. Seminars in Nephrology, 33(3), 265-76. https://doi.org/10.1016/j.semnephrol.2013.04.007
Weiner ID. Endocrine and Hypertensive Disorders of Potassium Regulation: Primary Aldosteronism. Semin Nephrol. 2013;33(3):265-76. PubMed PMID: 23953804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism. A1 - Weiner,I David, PY - 2013/8/20/entrez PY - 2013/8/21/pubmed PY - 2014/3/19/medline KW - Aldosterone KW - aldosterone-producing adenoma KW - bilateral adrenal hyperplasia KW - hypertension KW - hypokalemia KW - renin SP - 265 EP - 76 JF - Seminars in nephrology JO - Semin Nephrol VL - 33 IS - 3 N2 - The identification of primary aldosteronism as a common cause of resistant hypertension is a significant advance in our ability to care for patients with hypertension. Primary aldosteronism is common, and when unrecognized is associated with an increased incidence of adverse cardiovascular outcomes. Identification of primary aldosteronism is based on use of the plasma aldosterone level, plasma renin activity, and the aldosterone:renin ratio. Differentiation between unilateral and bilateral autonomous adrenal aldosterone production then guides further therapy, with use of mineralocorticoid-receptor blockers for patients with bilateral autonomous adrenal aldosterone production and laparoscopic adrenalectomy for patients with unilateral autonomous aldosterone production. In this review, we discuss in detail the pathogenesis of primary aldosteronism-induced hypertension and potassium disorders, the evaluation of the patient with suspected primary aldosteronism, and the management of primary aldosteronism, both through medications and surgery. SN - 1558-4488 UR - https://www.unboundmedicine.com/medline/citation/23953804/Endocrine_and_hypertensive_disorders_of_potassium_regulation:_primary_aldosteronism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270-9295(13)00056-9 DB - PRIME DP - Unbound Medicine ER -