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Association of coffee consumption with all-cause and cardiovascular disease mortality.
Mayo Clin Proc 2013; 88(10):1066-74MC

Abstract

OBJECTIVE

To evaluate the association between coffee consumption and mortality from all causes and from cardiovascular disease.

PATIENTS AND METHODS

Data from the Aerobics Center Longitudinal Study representing 43,727 participants with 699,632 person-years of follow-up were included. Baseline data were collected by an in-person interview on the basis of standardized questionnaires and a medical examination, including fasting blood chemistry analysis, anthropometry, blood pressure, electrocardiography, and a maximal graded exercise test, between February 3, 1971, and December 30, 2002. Cox regression analysis was used to quantify the association between coffee consumption and all-cause and cause-specific mortality.

RESULTS

During the 17-year median follow-up, 2512 deaths occurred (804 [32%] due to cardiovascular disease). In multivariate analyses, coffee intake was positively associated with all-cause mortality in men. Men who drank more than 28 cups of coffee per week had higher all-cause mortality (hazard ratio [HR], 1.21; 95% CI, 1.04-1.40). However, after stratification based on age, younger (<55 years old) men and women showed a significant association between high coffee consumption (>28 cups per week) and all-cause mortality after adjusting for potential confounders and fitness level (HR, 1.56; 95% CI, 1.30-1.87 for men; and HR, 2.13; 95% CI, 1.26-3.59 for women).

CONCLUSION

In this large cohort, a positive association between coffee consumption and all-cause mortality was observed in men and in men and women younger than 55 years. On the basis of these findings, it seems appropriate to suggest that younger people avoid heavy coffee consumption (ie, averaging >4 cups per day). However, this finding should be assessed in future studies of other populations.

Authors+Show Affiliations

Department of Biostatistics and Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia. Electronic address: LIU272@email.sc.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23953850

Citation

Liu, Junxiu, et al. "Association of Coffee Consumption With All-cause and Cardiovascular Disease Mortality." Mayo Clinic Proceedings, vol. 88, no. 10, 2013, pp. 1066-74.
Liu J, Sui X, Lavie CJ, et al. Association of coffee consumption with all-cause and cardiovascular disease mortality. Mayo Clin Proc. 2013;88(10):1066-74.
Liu, J., Sui, X., Lavie, C. J., Hebert, J. R., Earnest, C. P., Zhang, J., & Blair, S. N. (2013). Association of coffee consumption with all-cause and cardiovascular disease mortality. Mayo Clinic Proceedings, 88(10), pp. 1066-74. doi:10.1016/j.mayocp.2013.06.020.
Liu J, et al. Association of Coffee Consumption With All-cause and Cardiovascular Disease Mortality. Mayo Clin Proc. 2013;88(10):1066-74. PubMed PMID: 23953850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of coffee consumption with all-cause and cardiovascular disease mortality. AU - Liu,Junxiu, AU - Sui,Xuemei, AU - Lavie,Carl J, AU - Hebert,James R, AU - Earnest,Conrad P, AU - Zhang,Jiajia, AU - Blair,Steven N, Y1 - 2013/08/15/ PY - 2013/04/08/received PY - 2013/06/03/revised PY - 2013/06/06/accepted PY - 2013/8/20/entrez PY - 2013/8/21/pubmed PY - 2013/12/16/medline KW - ACLS KW - Aerobics Center Longitudinal Study KW - BMI KW - CRF KW - CVD KW - body mass index KW - cardiorespiratory fitness KW - cardiovascular disease SP - 1066 EP - 74 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 88 IS - 10 N2 - OBJECTIVE: To evaluate the association between coffee consumption and mortality from all causes and from cardiovascular disease. PATIENTS AND METHODS: Data from the Aerobics Center Longitudinal Study representing 43,727 participants with 699,632 person-years of follow-up were included. Baseline data were collected by an in-person interview on the basis of standardized questionnaires and a medical examination, including fasting blood chemistry analysis, anthropometry, blood pressure, electrocardiography, and a maximal graded exercise test, between February 3, 1971, and December 30, 2002. Cox regression analysis was used to quantify the association between coffee consumption and all-cause and cause-specific mortality. RESULTS: During the 17-year median follow-up, 2512 deaths occurred (804 [32%] due to cardiovascular disease). In multivariate analyses, coffee intake was positively associated with all-cause mortality in men. Men who drank more than 28 cups of coffee per week had higher all-cause mortality (hazard ratio [HR], 1.21; 95% CI, 1.04-1.40). However, after stratification based on age, younger (<55 years old) men and women showed a significant association between high coffee consumption (>28 cups per week) and all-cause mortality after adjusting for potential confounders and fitness level (HR, 1.56; 95% CI, 1.30-1.87 for men; and HR, 2.13; 95% CI, 1.26-3.59 for women). CONCLUSION: In this large cohort, a positive association between coffee consumption and all-cause mortality was observed in men and in men and women younger than 55 years. On the basis of these findings, it seems appropriate to suggest that younger people avoid heavy coffee consumption (ie, averaging >4 cups per day). However, this finding should be assessed in future studies of other populations. SN - 1942-5546 UR - https://www.unboundmedicine.com/medline/citation/23953850/Association_of_coffee_consumption_with_all_cause_and_cardiovascular_disease_mortality_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(13)00578-8 DB - PRIME DP - Unbound Medicine ER -