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Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions: assessment by optical coherence tomography and intravascular ultrasound.
JACC Cardiovasc Interv 2013; 6(9):945-54JC

Abstract

OBJECTIVES

This study sought to determine whether systemic levels of pentraxin 3 (PTX3), a novel inflammatory marker, are associated with thin-cap fibroatheroma (TCFA).

BACKGROUND

Biomarkers predicting the presence of TCFA in vivo have not been established.

METHODS

We evaluated 75 patients (stable angina pectoris, n = 47; acute coronary syndrome, n = 28) with de novo culprit lesions who were examined by optical coherence tomography and intravascular ultrasound. We defined TCFA as lipid-rich plaque with a fibrous cap <65 μm thick. Systemic levels of PTX3 were compared between patients with and without TCFA.

RESULTS

Thirty-eight and 37 patients with and without TCFA, respectively, were identified. Levels of PTX3 were significantly higher in patients with than in those without TCFA (p < 0.001) and correlated inversely with fibrous cap thickness (r = -0.71, p = 0.001) and positively with the remodeling index (r = 0.25, p = 0.037). Multivariate logistic regression analysis showed that a higher PTX3 level was the most powerful predictor of TCFA (odds ratio: 3.26, 95% confidence interval: 1.75 to 6.05, p < 0.001). Receiver-operating characteristic curve analysis showed that >3.24 ng/ml of PTX3 could predict TCFA with 84% sensitivity and 86% specificity.

CONCLUSIONS

Higher levels of systemic PTX3 are associated with TCFA. Systemic PTX3 levels comprise a useful inflammatory marker that reflects coronary plaque vulnerability.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23954061

Citation

Koga, Seiji, et al. "Elevated Levels of Systemic Pentraxin 3 Are Associated With Thin-cap Fibroatheroma in Coronary Culprit Lesions: Assessment By Optical Coherence Tomography and Intravascular Ultrasound." JACC. Cardiovascular Interventions, vol. 6, no. 9, 2013, pp. 945-54.
Koga S, Ikeda S, Yoshida T, et al. Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions: assessment by optical coherence tomography and intravascular ultrasound. JACC Cardiovasc Interv. 2013;6(9):945-54.
Koga, S., Ikeda, S., Yoshida, T., Nakata, T., Takeno, M., Masuda, N., ... Maemura, K. (2013). Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions: assessment by optical coherence tomography and intravascular ultrasound. JACC. Cardiovascular Interventions, 6(9), pp. 945-54. doi:10.1016/j.jcin.2013.04.024.
Koga S, et al. Elevated Levels of Systemic Pentraxin 3 Are Associated With Thin-cap Fibroatheroma in Coronary Culprit Lesions: Assessment By Optical Coherence Tomography and Intravascular Ultrasound. JACC Cardiovasc Interv. 2013;6(9):945-54. PubMed PMID: 23954061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions: assessment by optical coherence tomography and intravascular ultrasound. AU - Koga,Seiji, AU - Ikeda,Satoshi, AU - Yoshida,Takeo, AU - Nakata,Tomoo, AU - Takeno,Masayoshi, AU - Masuda,Nobuhito, AU - Koide,Yuji, AU - Kawano,Hiroaki, AU - Maemura,Koji, Y1 - 2013/08/14/ PY - 2012/12/27/received PY - 2013/03/27/revised PY - 2013/04/11/accepted PY - 2013/8/20/entrez PY - 2013/8/21/pubmed PY - 2014/5/20/medline KW - ACS KW - AMI KW - C-reactive protein KW - CRP KW - CSA KW - EEM KW - IVUS KW - OCT KW - P+M KW - PTX3 KW - SAP KW - TCFA KW - UAP KW - acute coronary syndromes KW - acute myocardial infarction KW - cross-sectional area KW - external elastic membrane KW - high-sensitivity C-reaction protein KW - hs-CRP KW - intravascular ultrasound KW - optical coherence tomography KW - pentraxin 3 KW - plaque plus media KW - stable angina pectoris KW - thin-cap fibroatheroma KW - unstable angina pectoris KW - vulnerable plaque SP - 945 EP - 54 JF - JACC. Cardiovascular interventions JO - JACC Cardiovasc Interv VL - 6 IS - 9 N2 - OBJECTIVES: This study sought to determine whether systemic levels of pentraxin 3 (PTX3), a novel inflammatory marker, are associated with thin-cap fibroatheroma (TCFA). BACKGROUND: Biomarkers predicting the presence of TCFA in vivo have not been established. METHODS: We evaluated 75 patients (stable angina pectoris, n = 47; acute coronary syndrome, n = 28) with de novo culprit lesions who were examined by optical coherence tomography and intravascular ultrasound. We defined TCFA as lipid-rich plaque with a fibrous cap <65 μm thick. Systemic levels of PTX3 were compared between patients with and without TCFA. RESULTS: Thirty-eight and 37 patients with and without TCFA, respectively, were identified. Levels of PTX3 were significantly higher in patients with than in those without TCFA (p < 0.001) and correlated inversely with fibrous cap thickness (r = -0.71, p = 0.001) and positively with the remodeling index (r = 0.25, p = 0.037). Multivariate logistic regression analysis showed that a higher PTX3 level was the most powerful predictor of TCFA (odds ratio: 3.26, 95% confidence interval: 1.75 to 6.05, p < 0.001). Receiver-operating characteristic curve analysis showed that >3.24 ng/ml of PTX3 could predict TCFA with 84% sensitivity and 86% specificity. CONCLUSIONS: Higher levels of systemic PTX3 are associated with TCFA. Systemic PTX3 levels comprise a useful inflammatory marker that reflects coronary plaque vulnerability. SN - 1876-7605 UR - https://www.unboundmedicine.com/medline/citation/23954061/Elevated_levels_of_systemic_pentraxin_3_are_associated_with_thin_cap_fibroatheroma_in_coronary_culprit_lesions:_assessment_by_optical_coherence_tomography_and_intravascular_ultrasound_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1936-8798(13)01116-3 DB - PRIME DP - Unbound Medicine ER -