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Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke.
Gene. 2013 Oct 25; 529(2):257-61.GENE

Abstract

OBJECTIVES

Ischemic stroke is influenced by both environmental and genetic factors. The CD40/CD40L system is related to proinflammatory and prothrombogenic responses, which are involved in the pathophysiology of ischemic stroke. The aim of this study was to evaluate association between the CD40 -1C/T single nucleotide polymorphism (SNP) and ischemic stroke in a Chinese population.

METHODS

We conducted a case-control study including 286 ischemic stroke patients and 336 controls. CD40 -1C/T SNP was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods, and evaluated its relevance to ischemic stroke susceptibility.

RESULTS

Significantly increased ischemic stroke risk was found to be associated with the T allele of CD40 -1C/T (OR=1.273, 95% CI=1.016-1.594). The frequencies of CT and TT/CT genotypes of CD40 -1C/T in ischemic stroke patients were significantly higher than those of controls, respectively (for CT: OR=2.350, 95% CI=1.601-3.449; for TT/CT: OR=2.148, 95% CI=1.479-3.119). And, similar results were obtained after adjusting non-matched variables. We found that the frequency of carried T genotypes (TT and TT/CT) was significantly increased in patients with history of stroke compared with patients without (for TT: OR=6.538, 95%CI=1.655-25.833; for TT/CT: OR=3.469, 95%CI=1.031-11.670), respectively.

CONCLUSIONS

The findings suggested that the CD40 -1C/T polymorphism might contribute to the susceptibility to ischemic stroke in the Chinese population, and might be associated with history of previous stroke.

Authors+Show Affiliations

Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23954880

Citation

Ma, Ying, et al. "Single Nucleotide Polymorphism of CD40 in the 5'-untranslated Region Is Associated With Ischemic Stroke." Gene, vol. 529, no. 2, 2013, pp. 257-61.
Ma Y, Wang SX, Liu Y, et al. Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke. Gene. 2013;529(2):257-61.
Ma, Y., Wang, S. X., Liu, Y., Peng, G. G., Wang, X. M., Zhang, B., Wu, B. H., & Yu, J. M. (2013). Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke. Gene, 529(2), 257-61. https://doi.org/10.1016/j.gene.2013.07.086
Ma Y, et al. Single Nucleotide Polymorphism of CD40 in the 5'-untranslated Region Is Associated With Ischemic Stroke. Gene. 2013 Oct 25;529(2):257-61. PubMed PMID: 23954880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke. AU - Ma,Ying, AU - Wang,Shun-Xian, AU - Liu,Yun, AU - Peng,Guo-Guang, AU - Wang,Xiao-Ming, AU - Zhang,Bo, AU - Wu,Bi-Hua, AU - Yu,Ju-Ming, Y1 - 2013/08/14/ PY - 2013/05/03/received PY - 2013/07/04/revised PY - 2013/07/23/accepted PY - 2013/8/20/entrez PY - 2013/8/21/pubmed PY - 2013/11/13/medline KW - 5′-UTR KW - 5′-untranslated region KW - CD40 KW - CD40 ligand KW - CD40L KW - CE KW - CHD KW - CI KW - CNS KW - CT KW - Genetic susceptibility KW - HWE KW - Hardy–Weinberg equilibrium KW - ICD-9-CM KW - International Classification of Diseases, 9th Revision, Clinical Modification KW - Ischemic stroke KW - LAA KW - LD KW - MRI KW - NIHSS KW - National Institutes of Health Stroke Scale KW - OR KW - PCR-RFLP KW - SNP KW - SVO KW - Single nucleotide polymorphism KW - TNFR KW - TOAST KW - Trial of Org10172 in Acute Stroke Treatment KW - cardioembolism KW - central nervous system KW - computed tomography KW - confidence intervals KW - coronary heart disease KW - large artery atherosclerosis KW - linkage disequilibrium KW - magnetic resonance imaging KW - odds ratio KW - polymerase chain reaction-restriction fragment length polymorphism KW - sCD40 KW - single nucleotide polymorphism KW - small vessel occlusion KW - soluble CD40 KW - tumor necrosis factor receptor SP - 257 EP - 61 JF - Gene JO - Gene VL - 529 IS - 2 N2 - OBJECTIVES: Ischemic stroke is influenced by both environmental and genetic factors. The CD40/CD40L system is related to proinflammatory and prothrombogenic responses, which are involved in the pathophysiology of ischemic stroke. The aim of this study was to evaluate association between the CD40 -1C/T single nucleotide polymorphism (SNP) and ischemic stroke in a Chinese population. METHODS: We conducted a case-control study including 286 ischemic stroke patients and 336 controls. CD40 -1C/T SNP was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods, and evaluated its relevance to ischemic stroke susceptibility. RESULTS: Significantly increased ischemic stroke risk was found to be associated with the T allele of CD40 -1C/T (OR=1.273, 95% CI=1.016-1.594). The frequencies of CT and TT/CT genotypes of CD40 -1C/T in ischemic stroke patients were significantly higher than those of controls, respectively (for CT: OR=2.350, 95% CI=1.601-3.449; for TT/CT: OR=2.148, 95% CI=1.479-3.119). And, similar results were obtained after adjusting non-matched variables. We found that the frequency of carried T genotypes (TT and TT/CT) was significantly increased in patients with history of stroke compared with patients without (for TT: OR=6.538, 95%CI=1.655-25.833; for TT/CT: OR=3.469, 95%CI=1.031-11.670), respectively. CONCLUSIONS: The findings suggested that the CD40 -1C/T polymorphism might contribute to the susceptibility to ischemic stroke in the Chinese population, and might be associated with history of previous stroke. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/23954880/Single_nucleotide_polymorphism_of_CD40_in_the_5'_untranslated_region_is_associated_with_ischemic_stroke_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(13)00994-3 DB - PRIME DP - Unbound Medicine ER -