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A contribution to the scientific assessment of degenerative and regenerative processes of peripheral nerve fibers following axonotmesis under the systemic administration of vitamins B1, B6 and B12--light and electron microscopy findings of the saphenous nerve in the rabbit.
Neurochirurgia (Stuttg). 1990 Jul; 33(4):113-21.N

Abstract

The present study investigates the de- and regenerative changes in the saphenous nerve of the rabbit following systemic treatment with a combination of the vitamins B1, B6 and B12 and a control group that was treated with physiological saline solution. Cold lesion of the nerve, which led to an optimal axonotmesis, was used to cause a secondary degeneration. After 4, 10 and 21 days the nerves were removed and investigated by light and electron microscopy. The morphological results show that the number of regenerating axons is higher and that of degenerating axons lower in the group treated with the given doses of the vitamins than in the comparable control group. Statements as to the metabolic processes and vitamins from which the better regeneration results are due are as yet not possible. Further investigations with the individual vitamins are necessary. Clinical indications of neurotoxicity due to the dose levels used were not observed in any of the cases.

Authors+Show Affiliations

Fachrichtung 3.1-Anatomie, Universität des Saarlandes, Homburg/Saar.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2395502

Citation

Becker, K W., et al. "A Contribution to the Scientific Assessment of Degenerative and Regenerative Processes of Peripheral Nerve Fibers Following Axonotmesis Under the Systemic Administration of Vitamins B1, B6 and B12--light and Electron Microscopy Findings of the Saphenous Nerve in the Rabbit." Neurochirurgia, vol. 33, no. 4, 1990, pp. 113-21.
Becker KW, Kienecker EW, Dick P. A contribution to the scientific assessment of degenerative and regenerative processes of peripheral nerve fibers following axonotmesis under the systemic administration of vitamins B1, B6 and B12--light and electron microscopy findings of the saphenous nerve in the rabbit. Neurochirurgia (Stuttg). 1990;33(4):113-21.
Becker, K. W., Kienecker, E. W., & Dick, P. (1990). A contribution to the scientific assessment of degenerative and regenerative processes of peripheral nerve fibers following axonotmesis under the systemic administration of vitamins B1, B6 and B12--light and electron microscopy findings of the saphenous nerve in the rabbit. Neurochirurgia, 33(4), 113-21.
Becker KW, Kienecker EW, Dick P. A Contribution to the Scientific Assessment of Degenerative and Regenerative Processes of Peripheral Nerve Fibers Following Axonotmesis Under the Systemic Administration of Vitamins B1, B6 and B12--light and Electron Microscopy Findings of the Saphenous Nerve in the Rabbit. Neurochirurgia (Stuttg). 1990;33(4):113-21. PubMed PMID: 2395502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A contribution to the scientific assessment of degenerative and regenerative processes of peripheral nerve fibers following axonotmesis under the systemic administration of vitamins B1, B6 and B12--light and electron microscopy findings of the saphenous nerve in the rabbit. AU - Becker,K W, AU - Kienecker,E W, AU - Dick,P, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 113 EP - 21 JF - Neurochirurgia JO - Neurochirurgia (Stuttg) VL - 33 IS - 4 N2 - The present study investigates the de- and regenerative changes in the saphenous nerve of the rabbit following systemic treatment with a combination of the vitamins B1, B6 and B12 and a control group that was treated with physiological saline solution. Cold lesion of the nerve, which led to an optimal axonotmesis, was used to cause a secondary degeneration. After 4, 10 and 21 days the nerves were removed and investigated by light and electron microscopy. The morphological results show that the number of regenerating axons is higher and that of degenerating axons lower in the group treated with the given doses of the vitamins than in the comparable control group. Statements as to the metabolic processes and vitamins from which the better regeneration results are due are as yet not possible. Further investigations with the individual vitamins are necessary. Clinical indications of neurotoxicity due to the dose levels used were not observed in any of the cases. SN - 0028-3819 UR - https://www.unboundmedicine.com/medline/citation/2395502/A_contribution_to_the_scientific_assessment_of_degenerative_and_regenerative_processes_of_peripheral_nerve_fibers_following_axonotmesis_under_the_systemic_administration_of_vitamins_B1_B6_and_B12__light_and_electron_microscopy_findings_of_the_saphenous_nerve_in_the_rabbit_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1053569 DB - PRIME DP - Unbound Medicine ER -