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Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome.
Ocul Immunol Inflamm. 2013 Dec; 21(6):478-85.OI

Abstract

Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The risk of developing uveitis is the greatest among patients with oligoarticular onset of disease. Clinical features of JIA-associated uveitis (JIAU) are nongranulomatous inflammation, anterior in location, insidious at onset, chronic course, and frequently asymptomatic in the absence of ocular structural complications. Uveitis in JIA can worsen over time with many sight-threatening complications, such as band keratopathy in the visual axis, posterior synechiae, cataract, secondary glaucoma, macular edema, hypotony, epiretinal membrane, and optic nerve edema. Different studies have pointed out that several factors are associated with poor prognosis, including young age at onset, male gender, short interval between diagnosis of arthritis and uveitis, severity of uveitis at onset, and antinuclear antibody (ANA) positivity. Although JIA associated-uveitis is still a serious blinding disease, we are at least able to identify the high-risk group.

Authors+Show Affiliations

John A. Moran Eye Center, Salt Lake City , Utah , USA .No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23957455

Citation

Vitale, Albert T., et al. "Juvenile Idiopathic Arthritis-associated Uveitis: Clinical Features and Complications, Risk Factors for Severe Course, and Visual Outcome." Ocular Immunology and Inflammation, vol. 21, no. 6, 2013, pp. 478-85.
Vitale AT, Graham E, de Boer JH. Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome. Ocul Immunol Inflamm. 2013;21(6):478-85.
Vitale, A. T., Graham, E., & de Boer, J. H. (2013). Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome. Ocular Immunology and Inflammation, 21(6), 478-85. https://doi.org/10.3109/09273948.2013.815785
Vitale AT, Graham E, de Boer JH. Juvenile Idiopathic Arthritis-associated Uveitis: Clinical Features and Complications, Risk Factors for Severe Course, and Visual Outcome. Ocul Immunol Inflamm. 2013;21(6):478-85. PubMed PMID: 23957455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome. AU - Vitale,Albert T, AU - Graham,Elizabeth, AU - de Boer,Joke H, Y1 - 2013/08/19/ PY - 2013/8/21/entrez PY - 2013/8/21/pubmed PY - 2014/8/20/medline SP - 478 EP - 85 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 21 IS - 6 N2 - Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The risk of developing uveitis is the greatest among patients with oligoarticular onset of disease. Clinical features of JIA-associated uveitis (JIAU) are nongranulomatous inflammation, anterior in location, insidious at onset, chronic course, and frequently asymptomatic in the absence of ocular structural complications. Uveitis in JIA can worsen over time with many sight-threatening complications, such as band keratopathy in the visual axis, posterior synechiae, cataract, secondary glaucoma, macular edema, hypotony, epiretinal membrane, and optic nerve edema. Different studies have pointed out that several factors are associated with poor prognosis, including young age at onset, male gender, short interval between diagnosis of arthritis and uveitis, severity of uveitis at onset, and antinuclear antibody (ANA) positivity. Although JIA associated-uveitis is still a serious blinding disease, we are at least able to identify the high-risk group. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/23957455/Juvenile_idiopathic_arthritis_associated_uveitis:_clinical_features_and_complications_risk_factors_for_severe_course_and_visual_outcome_ L2 - https://www.tandfonline.com/doi/full/10.3109/09273948.2013.815785 DB - PRIME DP - Unbound Medicine ER -