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Wnt/β-catenin signaling regulates neuronal differentiation of mesenchymal stem cells.
Biochem Biophys Res Commun 2013; 439(2):297-302BB

Abstract

Mesenchymal stem cells (MSCs) have been demonstrated to be able to differentiate into neuron-like cells, but the precise mechanisms controlling this process are unclear. Using neuron-specific enolase (NSE) and nestin as neuronal markers, we examined the role of Wnt/β-catenin signaling in MSC neuronal differentiation in present study. The results indicated that the expression of β-catenin increased markedly during the neuronal differentiation of MSCs. Blocking Wnt signaling by treating MSCs with β-catenin siRNA could decrease the differentiation of MSCs into neuron-like cells and up-regulation of Wnt signaling by treating MSCs with Wnt-3a could promote neuronal differentiation of MSCs. Above results suggest that Wnt/β-catenin signaling may play a pivotal role in neuronal differentiation of MSCs. Our data broaden the knowledge of molecular mechanisms involved in the neuronal differentiation of MSCs and provide a potential target for directing differentiation of MSCs for clinical application.

Authors+Show Affiliations

Institute of Bioengineering, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: qinyu3587@aliyun.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23958304

Citation

Yu, Qin, et al. "Wnt/β-catenin Signaling Regulates Neuronal Differentiation of Mesenchymal Stem Cells." Biochemical and Biophysical Research Communications, vol. 439, no. 2, 2013, pp. 297-302.
Yu Q, Liu L, Duan Y, et al. Wnt/β-catenin signaling regulates neuronal differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2013;439(2):297-302.
Yu, Q., Liu, L., Duan, Y., Wang, Y., Xuan, X., Zhou, L., & Liu, W. (2013). Wnt/β-catenin signaling regulates neuronal differentiation of mesenchymal stem cells. Biochemical and Biophysical Research Communications, 439(2), pp. 297-302. doi:10.1016/j.bbrc.2013.08.030.
Yu Q, et al. Wnt/β-catenin Signaling Regulates Neuronal Differentiation of Mesenchymal Stem Cells. Biochem Biophys Res Commun. 2013 Sep 20;439(2):297-302. PubMed PMID: 23958304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wnt/β-catenin signaling regulates neuronal differentiation of mesenchymal stem cells. AU - Yu,Qin, AU - Liu,Lizhen, AU - Duan,Yanping, AU - Wang,Yan, AU - Xuan,Xiaobo, AU - Zhou,Liping, AU - Liu,Wei, Y1 - 2013/08/17/ PY - 2013/08/07/received PY - 2013/08/09/accepted PY - 2013/8/21/entrez PY - 2013/8/21/pubmed PY - 2013/12/16/medline KW - Mesenchymal stem cells KW - Neuronal differentiation KW - Wnt-3a KW - Wnt/β-catenin signaling SP - 297 EP - 302 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 439 IS - 2 N2 - Mesenchymal stem cells (MSCs) have been demonstrated to be able to differentiate into neuron-like cells, but the precise mechanisms controlling this process are unclear. Using neuron-specific enolase (NSE) and nestin as neuronal markers, we examined the role of Wnt/β-catenin signaling in MSC neuronal differentiation in present study. The results indicated that the expression of β-catenin increased markedly during the neuronal differentiation of MSCs. Blocking Wnt signaling by treating MSCs with β-catenin siRNA could decrease the differentiation of MSCs into neuron-like cells and up-regulation of Wnt signaling by treating MSCs with Wnt-3a could promote neuronal differentiation of MSCs. Above results suggest that Wnt/β-catenin signaling may play a pivotal role in neuronal differentiation of MSCs. Our data broaden the knowledge of molecular mechanisms involved in the neuronal differentiation of MSCs and provide a potential target for directing differentiation of MSCs for clinical application. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/23958304/Wnt/β_catenin_signaling_regulates_neuronal_differentiation_of_mesenchymal_stem_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(13)01356-9 DB - PRIME DP - Unbound Medicine ER -