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2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus.
Physiol Behav 2013; 120:228-32PB

Abstract

The role of the endocannabinoid system in vomiting has been previously studied using several animal species. These investigations have clearly demonstrated an anti-emetic role for the eCB, anandamide, in these animal models; however, research concerning the role of 2-arhachidonoylglycerol (2AG) has been less clear. The aim of the present study was to assess the effects of exogenous 2AG administration in the house musk shrew, Suncus murinus. In Experiment 1, shrews were injected with vehicle or 2AG (1, 2, 5, 10 mg/kg) 15 min prior to behavioral testing in which the frequency of vomiting episodes was observed. In Experiment 2, shrews were pre-treated with 2AG (2, 5 mg/kg) prior to being administered the emetic drug, lithium chloride (LiCl). It was found that 2AG alone did not induce emesis, but interfered with vomiting in response to LiCl administration. The anti-emetic effects of 2AG in Suncus murinus do not appear to be mediated by CB1 receptors, as concomitant pretreatment with the CB1 receptor antagonist, SR141716, did not reverse the suppressive effects of 2AG. These results confirm that manipulations that increase levels of 2AG exert anti-emetic effects in the house musk shrew.

Authors+Show Affiliations

Department of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23958470

Citation

Sticht, M A., et al. "2-arachidonoylglycerol Interferes With Lithium-induced Vomiting in the House Musk Shrew, Suncus Murinus." Physiology & Behavior, vol. 120, 2013, pp. 228-32.
Sticht MA, Rock EM, Parker LA. 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. Physiol Behav. 2013;120:228-32.
Sticht, M. A., Rock, E. M., & Parker, L. A. (2013). 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. Physiology & Behavior, 120, pp. 228-32. doi:10.1016/j.physbeh.2013.08.015.
Sticht MA, Rock EM, Parker LA. 2-arachidonoylglycerol Interferes With Lithium-induced Vomiting in the House Musk Shrew, Suncus Murinus. Physiol Behav. 2013 Aug 15;120:228-32. PubMed PMID: 23958470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. AU - Sticht,M A, AU - Rock,E M, AU - Parker,L A, Y1 - 2013/08/16/ PY - 2013/05/06/received PY - 2013/07/30/revised PY - 2013/08/09/accepted PY - 2013/8/21/entrez PY - 2013/8/21/pubmed PY - 2014/5/27/medline KW - 2-Arachidonoylglycerol KW - Emesis KW - Endocannabinoid KW - Lithium chloride KW - Shrew SP - 228 EP - 32 JF - Physiology & behavior JO - Physiol. Behav. VL - 120 N2 - The role of the endocannabinoid system in vomiting has been previously studied using several animal species. These investigations have clearly demonstrated an anti-emetic role for the eCB, anandamide, in these animal models; however, research concerning the role of 2-arhachidonoylglycerol (2AG) has been less clear. The aim of the present study was to assess the effects of exogenous 2AG administration in the house musk shrew, Suncus murinus. In Experiment 1, shrews were injected with vehicle or 2AG (1, 2, 5, 10 mg/kg) 15 min prior to behavioral testing in which the frequency of vomiting episodes was observed. In Experiment 2, shrews were pre-treated with 2AG (2, 5 mg/kg) prior to being administered the emetic drug, lithium chloride (LiCl). It was found that 2AG alone did not induce emesis, but interfered with vomiting in response to LiCl administration. The anti-emetic effects of 2AG in Suncus murinus do not appear to be mediated by CB1 receptors, as concomitant pretreatment with the CB1 receptor antagonist, SR141716, did not reverse the suppressive effects of 2AG. These results confirm that manipulations that increase levels of 2AG exert anti-emetic effects in the house musk shrew. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/23958470/2_arachidonoylglycerol_interferes_with_lithium_induced_vomiting_in_the_house_musk_shrew_Suncus_murinus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(13)00263-1 DB - PRIME DP - Unbound Medicine ER -