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The prognostic importance of nuclear factor κB and hypoxia-inducible factor 1α in relation to the breast cancer subtype and the overall survival.
Appl Immunohistochem Mol Morphol. 2014 Jul; 22(6):464-70.AI

Abstract

Breast cancer shows extensive clinical and molecular heterogeneity. Prognostic factors are very important for outcome estimation in individual patients. Nuclear factor κB (NF-κB) and hypoxia-inducible factor 1α (HIF-1α) are transcriptional factors involved in cancerogenesis and in the metastatic spread of tumor cells. The aim of this study was to evaluate the expression of NF-κB and HIF-1α and to correlate the immunohistochemical expression of these markers with the breast cancer subtype and the patient outcome. The retrospective study included 208 cases of ductal invasive breast cancers stratified by the molecular subtype according to the St. Gallen 2011 classification. The Kaplan-Meier survival curve showed that an increased mortality risk was associated with tumors belonging not to the luminal A subtypes but to the Her-2-enriched and luminal B-Her-2-positive subtypes instead (P<0.001). Activation of NF-κB was associated with estrogen-negative tumors (P=0.005). We found a better overall survival in NF-κB-positive tumors in the luminal A subtype (P=0.021). This may be explained as a consequence of a possible tumor-suppressing effect of NF-κB. HIF-1α was related to the overall survival as a poor prognostic factor (P=0.036). In our opinion, the practical relevance of NF-κB and HIF-1α expression as prognostic indicators and potential targets for specific therapies deserve further investigation.

Authors+Show Affiliations

*Department of Cytology, Internal Medicine Clinic, Clinical Hospital Center †Department of Pathology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23958545

Citation

Rajković-Molek, Koraljka, et al. "The Prognostic Importance of Nuclear Factor κB and Hypoxia-inducible Factor 1α in Relation to the Breast Cancer Subtype and the Overall Survival." Applied Immunohistochemistry & Molecular Morphology : AIMM, vol. 22, no. 6, 2014, pp. 464-70.
Rajković-Molek K, Mustać E, Hadžisejdić I, et al. The prognostic importance of nuclear factor κB and hypoxia-inducible factor 1α in relation to the breast cancer subtype and the overall survival. Appl Immunohistochem Mol Morphol. 2014;22(6):464-70.
Rajković-Molek, K., Mustać, E., Hadžisejdić, I., & Jonjić, N. (2014). The prognostic importance of nuclear factor κB and hypoxia-inducible factor 1α in relation to the breast cancer subtype and the overall survival. Applied Immunohistochemistry & Molecular Morphology : AIMM, 22(6), 464-70. https://doi.org/10.1097/PAI.0b013e31829271ce
Rajković-Molek K, et al. The Prognostic Importance of Nuclear Factor κB and Hypoxia-inducible Factor 1α in Relation to the Breast Cancer Subtype and the Overall Survival. Appl Immunohistochem Mol Morphol. 2014;22(6):464-70. PubMed PMID: 23958545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prognostic importance of nuclear factor κB and hypoxia-inducible factor 1α in relation to the breast cancer subtype and the overall survival. AU - Rajković-Molek,Koraljka, AU - Mustać,Elvira, AU - Hadžisejdić,Ita, AU - Jonjić,Nives, PY - 2013/8/21/entrez PY - 2013/8/21/pubmed PY - 2015/3/13/medline SP - 464 EP - 70 JF - Applied immunohistochemistry & molecular morphology : AIMM JO - Appl. Immunohistochem. Mol. Morphol. VL - 22 IS - 6 N2 - Breast cancer shows extensive clinical and molecular heterogeneity. Prognostic factors are very important for outcome estimation in individual patients. Nuclear factor κB (NF-κB) and hypoxia-inducible factor 1α (HIF-1α) are transcriptional factors involved in cancerogenesis and in the metastatic spread of tumor cells. The aim of this study was to evaluate the expression of NF-κB and HIF-1α and to correlate the immunohistochemical expression of these markers with the breast cancer subtype and the patient outcome. The retrospective study included 208 cases of ductal invasive breast cancers stratified by the molecular subtype according to the St. Gallen 2011 classification. The Kaplan-Meier survival curve showed that an increased mortality risk was associated with tumors belonging not to the luminal A subtypes but to the Her-2-enriched and luminal B-Her-2-positive subtypes instead (P<0.001). Activation of NF-κB was associated with estrogen-negative tumors (P=0.005). We found a better overall survival in NF-κB-positive tumors in the luminal A subtype (P=0.021). This may be explained as a consequence of a possible tumor-suppressing effect of NF-κB. HIF-1α was related to the overall survival as a poor prognostic factor (P=0.036). In our opinion, the practical relevance of NF-κB and HIF-1α expression as prognostic indicators and potential targets for specific therapies deserve further investigation. SN - 1533-4058 UR - https://www.unboundmedicine.com/medline/citation/23958545/The_Prognostic_Importance_of_Nuclear_Factor_κB_and_Hypoxia_inducible_Factor_1α_in_Relation_to_the_Breast_Cancer_Subtype_and_the_Overall_Survival_ L2 - http://dx.doi.org/10.1097/PAI.0b013e31829271ce DB - PRIME DP - Unbound Medicine ER -