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The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons.
Peptides. 2013 Nov; 49:21-6.P

Abstract

The anandamide monounsaturated analogue oleoylethanolamide (OEA) acts as satiety signal released from enterocytes upon the ingestion of dietary fats to prolong the interval to the next meal. This effect, which requires intact vagal fibers and intestinal PPAR-alpha receptors, is coupled to the increase of c-fos and oxytocin mRNA expression in neurons of the paraventricular nucleus (PVN) and is prevented by the intracerebroventricular administration of a selective oxytocin antagonist, thus suggesting a necessary role of oxytocinergic neurotransmission in the pro-satiety effect of OEA. By brain microdialysis and immunohistochemistry, in this study we demonstrate that OEA treatment can stimulate oxytocin neurosecretion from the PVN and enhance oxytocin expression at both axonal and somatodendritic levels of hypothalamic neurons. Such effects, which are maximum 2h after OEA administration, support the hypothesis that the satiety-inducing action of OEA is mediated by the activation of oxytocin hypothalamic neurons.

Authors+Show Affiliations

Department of Physiology and Pharmacology, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23959001

Citation

Romano, Adele, et al. "The Satiety Signal Oleoylethanolamide Stimulates Oxytocin Neurosecretion From Rat Hypothalamic Neurons." Peptides, vol. 49, 2013, pp. 21-6.
Romano A, Cassano T, Tempesta B, et al. The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. Peptides. 2013;49:21-6.
Romano, A., Cassano, T., Tempesta, B., Cianci, S., Dipasquale, P., Coccurello, R., Cuomo, V., & Gaetani, S. (2013). The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. Peptides, 49, 21-6. https://doi.org/10.1016/j.peptides.2013.08.006
Romano A, et al. The Satiety Signal Oleoylethanolamide Stimulates Oxytocin Neurosecretion From Rat Hypothalamic Neurons. Peptides. 2013;49:21-6. PubMed PMID: 23959001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. AU - Romano,Adele, AU - Cassano,Tommaso, AU - Tempesta,Bianca, AU - Cianci,Silvia, AU - Dipasquale,Pasqua, AU - Coccurello,Roberto, AU - Cuomo,Vincenzo, AU - Gaetani,Silvana, Y1 - 2013/08/16/ PY - 2013/07/24/received PY - 2013/08/06/revised PY - 2013/08/06/accepted PY - 2013/8/21/entrez PY - 2013/8/21/pubmed PY - 2014/7/8/medline SP - 21 EP - 6 JF - Peptides JO - Peptides VL - 49 N2 - The anandamide monounsaturated analogue oleoylethanolamide (OEA) acts as satiety signal released from enterocytes upon the ingestion of dietary fats to prolong the interval to the next meal. This effect, which requires intact vagal fibers and intestinal PPAR-alpha receptors, is coupled to the increase of c-fos and oxytocin mRNA expression in neurons of the paraventricular nucleus (PVN) and is prevented by the intracerebroventricular administration of a selective oxytocin antagonist, thus suggesting a necessary role of oxytocinergic neurotransmission in the pro-satiety effect of OEA. By brain microdialysis and immunohistochemistry, in this study we demonstrate that OEA treatment can stimulate oxytocin neurosecretion from the PVN and enhance oxytocin expression at both axonal and somatodendritic levels of hypothalamic neurons. Such effects, which are maximum 2h after OEA administration, support the hypothesis that the satiety-inducing action of OEA is mediated by the activation of oxytocin hypothalamic neurons. SN - 1873-5169 UR - https://www.unboundmedicine.com/medline/citation/23959001/The_satiety_signal_oleoylethanolamide_stimulates_oxytocin_neurosecretion_from_rat_hypothalamic_neurons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(13)00277-5 DB - PRIME DP - Unbound Medicine ER -