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Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study.

Abstract

Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and supplements was assessed in relation to prostate cancer incidence. A prospective cohort of 47,896 men aged 40-75 years was followed from 1986 to 2008 for prostate cancer incidence (N = 5,656), and they completed food frequency questionnaires (FFQs) every 4 years. A FRAP value was assigned to each item in the FFQ, and for each individual, TAC scores for diet, supplements and both (total) were calculated. Major contributors of TAC intake at baseline were coffee (28%), fruit and vegetables (23%) and dietary supplements (23%). In multivariate analyses for dietary TAC a weak inverse association was observed [highest versus lowest quintiles: 0.91 (0.83-1.00, p-trend = 0.03) for total prostate cancer and 0.81 (0.64-1.01, p-trend = 0.04) for advanced prostate cancer]; this association was mainly due to coffee. No association of total TAC on prostate cancer incidence was observed. A positive association with lethal and advanced prostate cancers was observed in the highest quintile of supplemental TAC intake: 1.28 (0.98-1.65, p-trend < 0.01) and 1.15 (0.92-1.43, p-trend = 0.04). The weak association between dietary antioxidant intake and reduced prostate cancer incidence may be related to specific antioxidants in coffee, to nonantioxidant coffee compounds or other effects of drinking coffee. The indication of increased risk for lethal and advanced prostate cancers with high TAC intake from supplements warrants further investigation.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, MA; Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

    , , , , , , , , ,

    Source

    International journal of cancer 134:5 2014 Mar 01 pg 1156-65

    MeSH

    Adult
    Aged
    Antioxidants
    Cohort Studies
    Follow-Up Studies
    Health Personnel
    Humans
    Incidence
    Male
    Middle Aged
    Prospective Studies
    Prostatic Neoplasms
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23959920

    Citation

    Russnes, Kjell M., et al. "Total Antioxidant Intake in Relation to Prostate Cancer Incidence in the Health Professionals Follow-Up Study." International Journal of Cancer, vol. 134, no. 5, 2014, pp. 1156-65.
    Russnes KM, Wilson KM, Epstein MM, et al. Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study. Int J Cancer. 2014;134(5):1156-65.
    Russnes, K. M., Wilson, K. M., Epstein, M. M., Kasperzyk, J. L., Stampfer, M. J., Kenfield, S. A., ... Mucci, L. A. (2014). Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study. International Journal of Cancer, 134(5), pp. 1156-65. doi:10.1002/ijc.28438.
    Russnes KM, et al. Total Antioxidant Intake in Relation to Prostate Cancer Incidence in the Health Professionals Follow-Up Study. Int J Cancer. 2014 Mar 1;134(5):1156-65. PubMed PMID: 23959920.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study. AU - Russnes,Kjell M, AU - Wilson,Kathryn M, AU - Epstein,Mara M, AU - Kasperzyk,Julie L, AU - Stampfer,Meir J, AU - Kenfield,Stacey A, AU - Smeland,Sigbjørn, AU - Blomhoff,Rune, AU - Giovannucci,Edward L, AU - Willett,Walter C, AU - Mucci,Lorelei A, Y1 - 2013/11/11/ PY - 2013/02/26/received PY - 2013/07/14/revised PY - 2013/07/25/accepted PY - 2013/8/21/entrez PY - 2013/8/21/pubmed PY - 2014/2/13/medline KW - antioxidants KW - diet KW - oxidative stress KW - prostate cancer KW - risk factors SP - 1156 EP - 65 JF - International journal of cancer JO - Int. J. Cancer VL - 134 IS - 5 N2 - Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and supplements was assessed in relation to prostate cancer incidence. A prospective cohort of 47,896 men aged 40-75 years was followed from 1986 to 2008 for prostate cancer incidence (N = 5,656), and they completed food frequency questionnaires (FFQs) every 4 years. A FRAP value was assigned to each item in the FFQ, and for each individual, TAC scores for diet, supplements and both (total) were calculated. Major contributors of TAC intake at baseline were coffee (28%), fruit and vegetables (23%) and dietary supplements (23%). In multivariate analyses for dietary TAC a weak inverse association was observed [highest versus lowest quintiles: 0.91 (0.83-1.00, p-trend = 0.03) for total prostate cancer and 0.81 (0.64-1.01, p-trend = 0.04) for advanced prostate cancer]; this association was mainly due to coffee. No association of total TAC on prostate cancer incidence was observed. A positive association with lethal and advanced prostate cancers was observed in the highest quintile of supplemental TAC intake: 1.28 (0.98-1.65, p-trend < 0.01) and 1.15 (0.92-1.43, p-trend = 0.04). The weak association between dietary antioxidant intake and reduced prostate cancer incidence may be related to specific antioxidants in coffee, to nonantioxidant coffee compounds or other effects of drinking coffee. The indication of increased risk for lethal and advanced prostate cancers with high TAC intake from supplements warrants further investigation. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23959920/Total_antioxidant_intake_in_relation_to_prostate_cancer_incidence_in_the_Health_Professionals_Follow_Up_Study_ L2 - https://doi.org/10.1002/ijc.28438 DB - PRIME DP - Unbound Medicine ER -