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A study of a new co-processed dry binder based on spray-dried lactose and microcrystalline cellulose.
Ceska Slov Farm. 2013 Jun; 62(3):127-31.CS

Abstract

The paper studies the compressibility and disintegration time of tablets from the co-processed dry binder DisintequikTM MCC in combination with two lubricants at two concentrations in dependence on compression force. It also compares identical parameters in the physical mixtures of the spray-dried lactose Flowlac® 100 and the microcrystalline cellulose Microcel® MC-102 in the ratios of 9 : 1, 8 : 2 and 7 : 3, again in combination with two lubricants of two concentrations at one compression force. The lubricants employed are magnesium stearate and poloxamer 407 in concentrations of 1% and 2%. Compressibility is evaluated by means of energy balance of compression and tensile strength of tablets. DisintequikTM MCC shows higher values of total energy of compression due to higher values of the energy accumulated by the tablet, higher plasticity, higher strength and a longer disintegration time of tablets than the physical mixture of spray-dried lactose and microcrystalline cellulose of a corresponding content. .

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Authors+Show Affiliations

Mužíková J
Department of Pharmaceutical Technology, Charles University in Prague, Hradec Kralove. muzikova@faf.cuni.cz
Sináglová P
No affiliation info available

MeSH

CelluloseExcipientsLactoseLubricantsPoloxamerStearic AcidsTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23961814

Citation

Mužíková, Jitka, and Pavla Sináglová. "A Study of a New Co-processed Dry Binder Based On Spray-dried Lactose and Microcrystalline Cellulose." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 62, no. 3, 2013, pp. 127-31.
Mužíková J, Sináglová P. A study of a new co-processed dry binder based on spray-dried lactose and microcrystalline cellulose. Ceska Slov Farm. 2013;62(3):127-31.
Mužíková, J., & Sináglová, P. (2013). A study of a new co-processed dry binder based on spray-dried lactose and microcrystalline cellulose. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 62(3), 127-31.
Mužíková J, Sináglová P. A Study of a New Co-processed Dry Binder Based On Spray-dried Lactose and Microcrystalline Cellulose. Ceska Slov Farm. 2013;62(3):127-31. PubMed PMID: 23961814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of a new co-processed dry binder based on spray-dried lactose and microcrystalline cellulose. AU - Mužíková,Jitka, AU - Sináglová,Pavla, PY - 2013/8/22/entrez PY - 2013/8/22/pubmed PY - 2015/10/17/medline SP - 127 EP - 31 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 62 IS - 3 N2 - The paper studies the compressibility and disintegration time of tablets from the co-processed dry binder DisintequikTM MCC in combination with two lubricants at two concentrations in dependence on compression force. It also compares identical parameters in the physical mixtures of the spray-dried lactose Flowlac® 100 and the microcrystalline cellulose Microcel® MC-102 in the ratios of 9 : 1, 8 : 2 and 7 : 3, again in combination with two lubricants of two concentrations at one compression force. The lubricants employed are magnesium stearate and poloxamer 407 in concentrations of 1% and 2%. Compressibility is evaluated by means of energy balance of compression and tensile strength of tablets. DisintequikTM MCC shows higher values of total energy of compression due to higher values of the energy accumulated by the tablet, higher plasticity, higher strength and a longer disintegration time of tablets than the physical mixture of spray-dried lactose and microcrystalline cellulose of a corresponding content. . SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/23961814/A_study_of_a_new_co_processed_dry_binder_based_on_spray_dried_lactose_and_microcrystalline_cellulose_ L2 - https://www.prolekare.cz/linkout/41242 DB - PRIME DP - Unbound Medicine ER -