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SFAs do not impair endothelial function and arterial stiffness.
Am J Clin Nutr 2013; 98(3):677-83AJ

Abstract

BACKGROUND

It is uncertain whether saturated fatty acids (SFAs) impair endothelial function and contribute to arterial stiffening.

OBJECTIVE

We tested the effects of replacing SFAs with monounsaturated fatty acids (MUFAs) or carbohydrates on endothelial function and arterial stiffness.

DESIGN

With the use of a parallel-designed randomized controlled trial in 121 insulin-resistant men and women, we measured vascular function after 1 mo of consumption of a high-SFA (HS) diet and after 24 wk after random assignment to the HS diet or diets that contained <10% SFAs and were high in either MUFAs or carbohydrates. The primary outcome was a change in flow-mediated dilation (FMD), and secondary outcomes were changes in carotid to femoral pulse wave velocity (PWV) and plasma 8-isoprostane F2α-III concentrations.

RESULTS

For 112 participants with data available for analysis on the specified outcomes, no significant differences were shown. FMD with the HS reference diet was 6.7 ± 2.2%, and changes (95% CIs) after 6 mo of intervention were +0.3 (-0.4, 1.1), -0.2 (-0.8, 0.5), and -0.1 (-0.6, 0.7) with HS, high-MUFA (HM), and high-carbohydrate (HC) diets, respectively. After consumption of the HS reference diet, the geometric mean (±SD) PWV was 7.67 ± 1.62 m/s, and mean percentages of changes (95% CIs) were -1.0 (-6.2, 4.3) with the HS diet, 2.7 (-1.4, 6.9) with the HM diet, and -1.0 (-5.5, 3.4) with the HC diet. With the HS reference diet, the geometric mean (±SD) plasma 8-isoprostane F2α-III concentration was 176 ± 85 pmol/L, and mean percentage of changes (95% CIs) were 1 (-12, 14) with the HS diet, 6 (-5, 16) with the HM diet, and 4 (-7, 16) with the HC diet.

CONCLUSION

The replacement of SFAs with MUFAs or carbohydrates in healthy subjects does not affect vascular function. This trial was registered at Current Controlled Trials (http://www.controlled-trials.com/ISRCTN) as ISRCTN 29111298.

Authors+Show Affiliations

Diabetes and Nutritional Sciences Division, King's College London, London, United Kingdom. tom.sanders@kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23964054

Citation

Sanders, Thomas A B., et al. "SFAs Do Not Impair Endothelial Function and Arterial Stiffness." The American Journal of Clinical Nutrition, vol. 98, no. 3, 2013, pp. 677-83.
Sanders TA, Lewis FJ, Goff LM, et al. SFAs do not impair endothelial function and arterial stiffness. Am J Clin Nutr. 2013;98(3):677-83.
Sanders, T. A., Lewis, F. J., Goff, L. M., & Chowienczyk, P. J. (2013). SFAs do not impair endothelial function and arterial stiffness. The American Journal of Clinical Nutrition, 98(3), pp. 677-83. doi:10.3945/ajcn.113.063644.
Sanders TA, et al. SFAs Do Not Impair Endothelial Function and Arterial Stiffness. Am J Clin Nutr. 2013;98(3):677-83. PubMed PMID: 23964054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SFAs do not impair endothelial function and arterial stiffness. AU - Sanders,Thomas A B, AU - Lewis,Fiona J, AU - Goff,Louise M, AU - Chowienczyk,Philip J, AU - ,, PY - 2013/8/22/entrez PY - 2013/8/22/pubmed PY - 2013/10/26/medline SP - 677 EP - 83 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 98 IS - 3 N2 - BACKGROUND: It is uncertain whether saturated fatty acids (SFAs) impair endothelial function and contribute to arterial stiffening. OBJECTIVE: We tested the effects of replacing SFAs with monounsaturated fatty acids (MUFAs) or carbohydrates on endothelial function and arterial stiffness. DESIGN: With the use of a parallel-designed randomized controlled trial in 121 insulin-resistant men and women, we measured vascular function after 1 mo of consumption of a high-SFA (HS) diet and after 24 wk after random assignment to the HS diet or diets that contained <10% SFAs and were high in either MUFAs or carbohydrates. The primary outcome was a change in flow-mediated dilation (FMD), and secondary outcomes were changes in carotid to femoral pulse wave velocity (PWV) and plasma 8-isoprostane F2α-III concentrations. RESULTS: For 112 participants with data available for analysis on the specified outcomes, no significant differences were shown. FMD with the HS reference diet was 6.7 ± 2.2%, and changes (95% CIs) after 6 mo of intervention were +0.3 (-0.4, 1.1), -0.2 (-0.8, 0.5), and -0.1 (-0.6, 0.7) with HS, high-MUFA (HM), and high-carbohydrate (HC) diets, respectively. After consumption of the HS reference diet, the geometric mean (±SD) PWV was 7.67 ± 1.62 m/s, and mean percentages of changes (95% CIs) were -1.0 (-6.2, 4.3) with the HS diet, 2.7 (-1.4, 6.9) with the HM diet, and -1.0 (-5.5, 3.4) with the HC diet. With the HS reference diet, the geometric mean (±SD) plasma 8-isoprostane F2α-III concentration was 176 ± 85 pmol/L, and mean percentage of changes (95% CIs) were 1 (-12, 14) with the HS diet, 6 (-5, 16) with the HM diet, and 4 (-7, 16) with the HC diet. CONCLUSION: The replacement of SFAs with MUFAs or carbohydrates in healthy subjects does not affect vascular function. This trial was registered at Current Controlled Trials (http://www.controlled-trials.com/ISRCTN) as ISRCTN 29111298. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23964054/SFAs_do_not_impair_endothelial_function_and_arterial_stiffness_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.063644 DB - PRIME DP - Unbound Medicine ER -