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A case of severe chronic progressive axonal polyradiculoneuropathy temporally associated with anti-CV2/CRMP5 antibodies.
J Clin Neuromuscul Dis. 2013 Sep; 15(1):13-8.JC

Abstract

OBJECTIVES

The involvement of the peripheral nervous system by anti-CV2/CRMP5 paraneoplastic antibodies is typically encountered as a mixed sensorimotor polyneuropathy. We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.

METHODS

Review of the patient's chart, nerve conduction/electromyographic studies, and nerve biopsy.

RESULTS

A 51-year-old man presented with a progressive quadriparesis over a 4-month period. Extensive evaluation for potential etiologies was significant only for positive anti-CV2/CRMP5 antibodies without detection of an underlying neoplasm. Despite multiple immunomodulatory therapies, the patient progressed and demonstrated electrodiagnostic evidence for a chronic axonal polyradiculoneuropathy with ongoing denervation. The patient eventually died of respiratory failure.

CONCLUSIONS

This case adds to the clinical spectrum of the peripheral nervous system involvement in patients with paraneoplastic anti-CV2/CRMP5 antibodies.

Authors+Show Affiliations

Department of Neurology, Baylor College of Medicine, Houston, TX, USA. yousefhannawi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23965404

Citation

Hannawi, Yousef, et al. "A Case of Severe Chronic Progressive Axonal Polyradiculoneuropathy Temporally Associated With anti-CV2/CRMP5 Antibodies." Journal of Clinical Neuromuscular Disease, vol. 15, no. 1, 2013, pp. 13-8.
Hannawi Y, Goldsmith CE, Kass JS, et al. A case of severe chronic progressive axonal polyradiculoneuropathy temporally associated with anti-CV2/CRMP5 antibodies. J Clin Neuromuscul Dis. 2013;15(1):13-8.
Hannawi, Y., Goldsmith, C. E., Kass, J. S., Olar, A., Ubogu, E. E., & Kalkonde, Y. V. (2013). A case of severe chronic progressive axonal polyradiculoneuropathy temporally associated with anti-CV2/CRMP5 antibodies. Journal of Clinical Neuromuscular Disease, 15(1), 13-8. https://doi.org/10.1097/CND.0b013e3182a04538
Hannawi Y, et al. A Case of Severe Chronic Progressive Axonal Polyradiculoneuropathy Temporally Associated With anti-CV2/CRMP5 Antibodies. J Clin Neuromuscul Dis. 2013;15(1):13-8. PubMed PMID: 23965404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of severe chronic progressive axonal polyradiculoneuropathy temporally associated with anti-CV2/CRMP5 antibodies. AU - Hannawi,Yousef, AU - Goldsmith,Corey E, AU - Kass,Joseph S, AU - Olar,Adriana, AU - Ubogu,Eroboghene E, AU - Kalkonde,Yogeshwar V, PY - 2013/8/23/entrez PY - 2013/8/24/pubmed PY - 2014/3/22/medline SP - 13 EP - 8 JF - Journal of clinical neuromuscular disease JO - J Clin Neuromuscul Dis VL - 15 IS - 1 N2 - OBJECTIVES: The involvement of the peripheral nervous system by anti-CV2/CRMP5 paraneoplastic antibodies is typically encountered as a mixed sensorimotor polyneuropathy. We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody. METHODS: Review of the patient's chart, nerve conduction/electromyographic studies, and nerve biopsy. RESULTS: A 51-year-old man presented with a progressive quadriparesis over a 4-month period. Extensive evaluation for potential etiologies was significant only for positive anti-CV2/CRMP5 antibodies without detection of an underlying neoplasm. Despite multiple immunomodulatory therapies, the patient progressed and demonstrated electrodiagnostic evidence for a chronic axonal polyradiculoneuropathy with ongoing denervation. The patient eventually died of respiratory failure. CONCLUSIONS: This case adds to the clinical spectrum of the peripheral nervous system involvement in patients with paraneoplastic anti-CV2/CRMP5 antibodies. SN - 1537-1611 UR - https://www.unboundmedicine.com/medline/citation/23965404/A_case_of_severe_chronic_progressive_axonal_polyradiculoneuropathy_temporally_associated_with_anti_CV2/CRMP5_antibodies_ L2 - http://dx.doi.org/10.1097/CND.0b013e3182a04538 DB - PRIME DP - Unbound Medicine ER -