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Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer: the PACIFIC study.
Cancer Epidemiol Biomarkers Prev 2013; 22(10):1913-7CE

Abstract

Genetic association studies have identified more than a dozen genes associated with risk of pancreatic cancer. Given this genetic heterogeneity, family history can be useful for identifying individuals at high risk for this disease. The goal of this analysis was to evaluate associations of family history of diabetes and family history of pancreatic cancer with risk of pancreatic cancer. PACIFIC is a case-control study based on two large health plans. Cases were diagnosed with pancreatic ductal adenocarcinoma (PDA) and controls were selected from the health plan enrollment databases and frequency matched to cases. Family history data were collected using an interviewer-administered questionnaire and were available on 654 cases and 697 controls. Logistic regression was used for the association analyses. First-degree relative history of diabetes was statistically significantly associated with increased risk of PDA [OR, 1.37; 95% confidence interval (CI), 1.10-1.71]. The highest risk of PDA was observed for an offspring with diabetes (OR, 1.95; 95% CI, 1.23-3.09). In addition, history of pancreatic cancer increased risk for PDA with an OR of 2.79 (95% CI, 1.44-4.08) for any first-degree relative history of pancreatic cancer. This population-based analysis showed that family history of diabetes was associated with increased risk of PDA and confirmed previous studies showing that first-degree family history of pancreatic cancer is associated with PDA. These results support the need for ongoing studies of genetic influences on pancreatic cancer in large samples and investigations of possible pleiotropic genetic effects on diabetes and pancreatic cancer.

Authors+Show Affiliations

Authors' Affiliations: Departments of Epidemiology and Gastroenterology, University of Washington; Group Health Research Institute and Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Research, Kaiser Permanente Northern California, Oakland, California; and Centre for Public Health Research, Massey University, Wellington, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23966578

Citation

Austin, Melissa A., et al. "Family History of Diabetes and Pancreatic Cancer as Risk Factors for Pancreatic Cancer: the PACIFIC Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 22, no. 10, 2013, pp. 1913-7.
Austin MA, Kuo E, Van Den Eeden SK, et al. Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer: the PACIFIC study. Cancer Epidemiol Biomarkers Prev. 2013;22(10):1913-7.
Austin, M. A., Kuo, E., Van Den Eeden, S. K., Mandelson, M. T., Brentnall, T. A., Kamineni, A., & Potter, J. D. (2013). Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer: the PACIFIC study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 22(10), pp. 1913-7. doi:10.1158/1055-9965.EPI-13-0518.
Austin MA, et al. Family History of Diabetes and Pancreatic Cancer as Risk Factors for Pancreatic Cancer: the PACIFIC Study. Cancer Epidemiol Biomarkers Prev. 2013;22(10):1913-7. PubMed PMID: 23966578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer: the PACIFIC study. AU - Austin,Melissa A, AU - Kuo,Elena, AU - Van Den Eeden,Stephen K, AU - Mandelson,Margaret T, AU - Brentnall,Teresa A, AU - Kamineni,Aruna, AU - Potter,John D, Y1 - 2013/08/21/ PY - 2013/8/23/entrez PY - 2013/8/24/pubmed PY - 2014/7/6/medline SP - 1913 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 22 IS - 10 N2 - Genetic association studies have identified more than a dozen genes associated with risk of pancreatic cancer. Given this genetic heterogeneity, family history can be useful for identifying individuals at high risk for this disease. The goal of this analysis was to evaluate associations of family history of diabetes and family history of pancreatic cancer with risk of pancreatic cancer. PACIFIC is a case-control study based on two large health plans. Cases were diagnosed with pancreatic ductal adenocarcinoma (PDA) and controls were selected from the health plan enrollment databases and frequency matched to cases. Family history data were collected using an interviewer-administered questionnaire and were available on 654 cases and 697 controls. Logistic regression was used for the association analyses. First-degree relative history of diabetes was statistically significantly associated with increased risk of PDA [OR, 1.37; 95% confidence interval (CI), 1.10-1.71]. The highest risk of PDA was observed for an offspring with diabetes (OR, 1.95; 95% CI, 1.23-3.09). In addition, history of pancreatic cancer increased risk for PDA with an OR of 2.79 (95% CI, 1.44-4.08) for any first-degree relative history of pancreatic cancer. This population-based analysis showed that family history of diabetes was associated with increased risk of PDA and confirmed previous studies showing that first-degree family history of pancreatic cancer is associated with PDA. These results support the need for ongoing studies of genetic influences on pancreatic cancer in large samples and investigations of possible pleiotropic genetic effects on diabetes and pancreatic cancer. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/23966578/Family_history_of_diabetes_and_pancreatic_cancer_as_risk_factors_for_pancreatic_cancer:_the_PACIFIC_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=23966578 DB - PRIME DP - Unbound Medicine ER -