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[Post-stroke depression treated with acupuncture and moxibustion: an evaluation of therapeutic effect and safety].
Zhongguo Zhen Jiu. 2013 Jun; 33(6):490-4.ZZ

Abstract

OBJECTIVE

To evaluate the efficacy and safety of acupuncture and moxibustion in the treatment of post-stroke depression (PSD) by regulating the liver and strengthening the root prescription.

METHODS

In light of the random controlled trial principle, 123 cases were randomized into an acupuncture-moxibustion group (42 cases), a medication group (40 cases) and an acupuncture + medication group (41 cases). In the acupuncture-moxibustion group, the therapy of regulating the liver and strengthening the root was applied. Acupuncture was given at Hegu (LI 4), Taichong (LR 3), Baihui (GV 20, Yintang (GV 29), etc. The granule moxibustion was applied at Zhongwan (CV 12), Xiawan (CV 10), Guanyuan (CV 4) and Qihai (CV 6). The treatment was given once a day and stopped in weekend. In the medication group, paroxetine hydrochloride tablets were prescribed for oral administration, 20 mg each day after breakfast. In the acupuncture + medication group, the therapies were adopted as the acupuncture-moxibustion group and the medication group. In the 2nd and 4th week of treatment, HAMD was used as the primary index and Barthel index as the secondary one for the efficacy assessment in the three groups respectively. The spleen and stomach syndrome scale of TCM was used for the assessment of TCM syndrome efficacy. Treatment emergent symptom scale (TESS) was applied for the safety assessment.

RESULTS

In the 4th week of treatment, the markedly effective rates were 69.0% (29/42), 65.0% (26/40) and 70.7% (29/41) in the acupuncture-moxibustion group, the medication group and the acupuncture + medication group respectively. The efficacies of anti-depression were similar in comparison among groups (P > 0.05). In the 2nd week of treatment, the improvement of HAMD score was significant in the acupuncture + medication group as compared with that before treatment and in comparison with the medication group (P < 0.05, P < 0.01). As for improving Barthel index, reducing the spleen and stomach symptom score of TCM and decreasing the score of TESS, the results in the acupuncture-moxibustion group and the acupuncture + medication group were superior to those in the medication group (P < 0.05, P < 0.01).

CONCLUSION

The therapy of acupuncture and moxibustion with regulating the liver and strengthening the root achieves the definite efficacy of anti-depression and presents the quite high safety in treatment.

Authors+Show Affiliations

Department of TCM, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Province, China. 21658135@qq.comNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

23967632

Citation

Nie, Rong-Rong, and Chun-Hua Huang. "[Post-stroke Depression Treated With Acupuncture and Moxibustion: an Evaluation of Therapeutic Effect and Safety]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 33, no. 6, 2013, pp. 490-4.
Nie RR, Huang CH. [Post-stroke depression treated with acupuncture and moxibustion: an evaluation of therapeutic effect and safety]. Zhongguo Zhen Jiu. 2013;33(6):490-4.
Nie, R. R., & Huang, C. H. (2013). [Post-stroke depression treated with acupuncture and moxibustion: an evaluation of therapeutic effect and safety]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 33(6), 490-4.
Nie RR, Huang CH. [Post-stroke Depression Treated With Acupuncture and Moxibustion: an Evaluation of Therapeutic Effect and Safety]. Zhongguo Zhen Jiu. 2013;33(6):490-4. PubMed PMID: 23967632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Post-stroke depression treated with acupuncture and moxibustion: an evaluation of therapeutic effect and safety]. AU - Nie,Rong-Rong, AU - Huang,Chun-Hua, PY - 2013/8/24/entrez PY - 2013/8/24/pubmed PY - 2013/9/18/medline SP - 490 EP - 4 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 33 IS - 6 N2 - OBJECTIVE: To evaluate the efficacy and safety of acupuncture and moxibustion in the treatment of post-stroke depression (PSD) by regulating the liver and strengthening the root prescription. METHODS: In light of the random controlled trial principle, 123 cases were randomized into an acupuncture-moxibustion group (42 cases), a medication group (40 cases) and an acupuncture + medication group (41 cases). In the acupuncture-moxibustion group, the therapy of regulating the liver and strengthening the root was applied. Acupuncture was given at Hegu (LI 4), Taichong (LR 3), Baihui (GV 20, Yintang (GV 29), etc. The granule moxibustion was applied at Zhongwan (CV 12), Xiawan (CV 10), Guanyuan (CV 4) and Qihai (CV 6). The treatment was given once a day and stopped in weekend. In the medication group, paroxetine hydrochloride tablets were prescribed for oral administration, 20 mg each day after breakfast. In the acupuncture + medication group, the therapies were adopted as the acupuncture-moxibustion group and the medication group. In the 2nd and 4th week of treatment, HAMD was used as the primary index and Barthel index as the secondary one for the efficacy assessment in the three groups respectively. The spleen and stomach syndrome scale of TCM was used for the assessment of TCM syndrome efficacy. Treatment emergent symptom scale (TESS) was applied for the safety assessment. RESULTS: In the 4th week of treatment, the markedly effective rates were 69.0% (29/42), 65.0% (26/40) and 70.7% (29/41) in the acupuncture-moxibustion group, the medication group and the acupuncture + medication group respectively. The efficacies of anti-depression were similar in comparison among groups (P > 0.05). In the 2nd week of treatment, the improvement of HAMD score was significant in the acupuncture + medication group as compared with that before treatment and in comparison with the medication group (P < 0.05, P < 0.01). As for improving Barthel index, reducing the spleen and stomach symptom score of TCM and decreasing the score of TESS, the results in the acupuncture-moxibustion group and the acupuncture + medication group were superior to those in the medication group (P < 0.05, P < 0.01). CONCLUSION: The therapy of acupuncture and moxibustion with regulating the liver and strengthening the root achieves the definite efficacy of anti-depression and presents the quite high safety in treatment. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/23967632/[Post_stroke_depression_treated_with_acupuncture_and_moxibustion:_an_evaluation_of_therapeutic_effect_and_safety]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -
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