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Influence of disease severity on fatigue in patients with Parkinson's disease is mainly mediated by symptoms of depression.
Eur Neurol. 2013; 70(3-4):201-9.EN

Abstract

PURPOSE

Fatigue is a frequent non-motor complaint of patients with Parkinson's disease (PD). Despite increasing knowledge on fatigue, the factors leading to its development are still not recognised. The aim of this investigation was to test, using structural equation modelling, the hypothesis that the influence of disease severity on fatigue is mediated by symptoms of depression in patients with PD.

METHOD

The sample consisted of 190 PD patients (93 men, 48.9%, mean age 68.2±9.3 years, mean disease duration 6.4±4.7 years) recruited from hospitals and outpatient clinics in the East Slovakia region. The Multidimensional Fatigue Inventory, the Hospital Anxiety and Depression Scale and the Unified Parkinson's Disease Rating Scale were used. LISREL was used to analyse the data.

RESULTS

Disease severity was directly associated with symptoms of depression (β=0.26) and directly affected fatigue in terms of increased levels of general fatigue (β=0.35), physical fatigue (β=0.22), reduced activity (β=0.31) and mental fatigue (β=0.29), but did not directly influence reduced motivation. Symptoms of depression mediated the impact of disease severity on general fatigue (β=0.25), on reduced activity (β=0.31) and on mental fatigue (β=0.28), but not on physical fatigue. Reduced motivation was not mediated, but directly influenced by more symptoms of depression (β=0.82).

DISCUSSION

Since increased symptoms of depression mediate the impact of disease severity on three domains of fatigue in PD patients, disease management should focus on the treatment of PD and symptoms of depression.

Authors+Show Affiliations

Department of Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23969578

Citation

van Dijk, Jitse P., et al. "Influence of Disease Severity On Fatigue in Patients With Parkinson's Disease Is Mainly Mediated By Symptoms of Depression." European Neurology, vol. 70, no. 3-4, 2013, pp. 201-9.
van Dijk JP, Havlikova E, Rosenberger J, et al. Influence of disease severity on fatigue in patients with Parkinson's disease is mainly mediated by symptoms of depression. Eur Neurol. 2013;70(3-4):201-9.
van Dijk, J. P., Havlikova, E., Rosenberger, J., Nagyova, I., Skorvanek, M., Gdovinova, Z., Lok, W., Groothoff, J. W., & Middel, B. (2013). Influence of disease severity on fatigue in patients with Parkinson's disease is mainly mediated by symptoms of depression. European Neurology, 70(3-4), 201-9. https://doi.org/10.1159/000351779
van Dijk JP, et al. Influence of Disease Severity On Fatigue in Patients With Parkinson's Disease Is Mainly Mediated By Symptoms of Depression. Eur Neurol. 2013;70(3-4):201-9. PubMed PMID: 23969578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of disease severity on fatigue in patients with Parkinson's disease is mainly mediated by symptoms of depression. AU - van Dijk,Jitse P, AU - Havlikova,Eva, AU - Rosenberger,Jaroslav, AU - Nagyova,Iveta, AU - Skorvanek,Matej, AU - Gdovinova,Zuzana, AU - Lok,Willem, AU - Groothoff,Johan W, AU - Middel,Berrie, Y1 - 2013/08/22/ PY - 2012/11/11/received PY - 2013/04/25/accepted PY - 2013/8/24/entrez PY - 2013/8/24/pubmed PY - 2014/6/12/medline SP - 201 EP - 9 JF - European neurology JO - Eur Neurol VL - 70 IS - 3-4 N2 - PURPOSE: Fatigue is a frequent non-motor complaint of patients with Parkinson's disease (PD). Despite increasing knowledge on fatigue, the factors leading to its development are still not recognised. The aim of this investigation was to test, using structural equation modelling, the hypothesis that the influence of disease severity on fatigue is mediated by symptoms of depression in patients with PD. METHOD: The sample consisted of 190 PD patients (93 men, 48.9%, mean age 68.2±9.3 years, mean disease duration 6.4±4.7 years) recruited from hospitals and outpatient clinics in the East Slovakia region. The Multidimensional Fatigue Inventory, the Hospital Anxiety and Depression Scale and the Unified Parkinson's Disease Rating Scale were used. LISREL was used to analyse the data. RESULTS: Disease severity was directly associated with symptoms of depression (β=0.26) and directly affected fatigue in terms of increased levels of general fatigue (β=0.35), physical fatigue (β=0.22), reduced activity (β=0.31) and mental fatigue (β=0.29), but did not directly influence reduced motivation. Symptoms of depression mediated the impact of disease severity on general fatigue (β=0.25), on reduced activity (β=0.31) and on mental fatigue (β=0.28), but not on physical fatigue. Reduced motivation was not mediated, but directly influenced by more symptoms of depression (β=0.82). DISCUSSION: Since increased symptoms of depression mediate the impact of disease severity on three domains of fatigue in PD patients, disease management should focus on the treatment of PD and symptoms of depression. SN - 1421-9913 UR - https://www.unboundmedicine.com/medline/citation/23969578/Influence_of_disease_severity_on_fatigue_in_patients_with_Parkinson's_disease_is_mainly_mediated_by_symptoms_of_depression_ L2 - https://www.karger.com?DOI=10.1159/000351779 DB - PRIME DP - Unbound Medicine ER -