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Toxicological findings of synthetic cannabinoids in recreational users.
J Anal Toxicol 2013; 37(8):534-41JA

Abstract

In recent years, several synthetic cannabinoid compounds have become popular recreational drugs of abuse because of their psychoactive properties. This paper presents toxicological findings of synthetic cannabinoids in whole blood from some cases of severe intoxication including quantitative data from recreational users and a fatal intoxication. Samples were analyzed by liquid chromatography-tandem mass spectrometry in a scheduled multiple reaction mode after a basic liquid extraction. Twenty-nine synthetic cannabinoids were included in the method. In our data set of ~3000 cases, 28% were found positive for one or more synthetic cannabinoid(s). The most common finding was AM-2201. Most of the analytes had median concentrations of <0.5 ng/g in agreement with other published data. The emerging drugs MAM-2201 (n = 151) and UR-144 (n = 181) had mean (median) concentrations of 1.04 (0.37) and 1.26 (0.34), respectively. The toxicity of the synthetic cannabinoids seems to be worse than that of natural cannabis, probably owing to the higher potency and perhaps also to the presence of several different cannabinoids in the smoked incense and the difficulties of proper dosing. The acute toxic effects may under certain circumstances contribute to death.

Authors+Show Affiliations

1Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping SE-58758, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23970540

Citation

Kronstrand, Robert, et al. "Toxicological Findings of Synthetic Cannabinoids in Recreational Users." Journal of Analytical Toxicology, vol. 37, no. 8, 2013, pp. 534-41.
Kronstrand R, Roman M, Andersson M, et al. Toxicological findings of synthetic cannabinoids in recreational users. J Anal Toxicol. 2013;37(8):534-41.
Kronstrand, R., Roman, M., Andersson, M., & Eklund, A. (2013). Toxicological findings of synthetic cannabinoids in recreational users. Journal of Analytical Toxicology, 37(8), pp. 534-41. doi:10.1093/jat/bkt068.
Kronstrand R, et al. Toxicological Findings of Synthetic Cannabinoids in Recreational Users. J Anal Toxicol. 2013;37(8):534-41. PubMed PMID: 23970540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicological findings of synthetic cannabinoids in recreational users. AU - Kronstrand,Robert, AU - Roman,Markus, AU - Andersson,Mikael, AU - Eklund,Arne, Y1 - 2013/08/22/ PY - 2013/8/24/entrez PY - 2013/8/24/pubmed PY - 2014/4/15/medline SP - 534 EP - 41 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 37 IS - 8 N2 - In recent years, several synthetic cannabinoid compounds have become popular recreational drugs of abuse because of their psychoactive properties. This paper presents toxicological findings of synthetic cannabinoids in whole blood from some cases of severe intoxication including quantitative data from recreational users and a fatal intoxication. Samples were analyzed by liquid chromatography-tandem mass spectrometry in a scheduled multiple reaction mode after a basic liquid extraction. Twenty-nine synthetic cannabinoids were included in the method. In our data set of ~3000 cases, 28% were found positive for one or more synthetic cannabinoid(s). The most common finding was AM-2201. Most of the analytes had median concentrations of <0.5 ng/g in agreement with other published data. The emerging drugs MAM-2201 (n = 151) and UR-144 (n = 181) had mean (median) concentrations of 1.04 (0.37) and 1.26 (0.34), respectively. The toxicity of the synthetic cannabinoids seems to be worse than that of natural cannabis, probably owing to the higher potency and perhaps also to the presence of several different cannabinoids in the smoked incense and the difficulties of proper dosing. The acute toxic effects may under certain circumstances contribute to death. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/23970540/Toxicological_findings_of_synthetic_cannabinoids_in_recreational_users_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bkt068 DB - PRIME DP - Unbound Medicine ER -