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Effect of dietary supplemented andrographolide on growth, non-specific immune parameters and resistance against Aeromonas hydrophila in Labeo rohita (Hamilton).
Fish Shellfish Immunol. 2013 Nov; 35(5):1433-41.FS

Abstract

The present study evaluated the effect of dietary andrographolide (EC 50%) on growth, non-specific immune parameters and disease resistance against Aeromonas hydrophila infection in Indian major carp, Labeo rohita fingerlings. Fishes were fed with formulated diet containing andrographolide as T0 (0.00%), T1 (0.05%), T2 (0.10%), T3 (0.20%), T4 (0.40%) and T5 (0.80%) for 42 days. Fishes were challenged with A. hydrophila 42 days post feeding and relative percentage survival (RPS) was recorded over 14 days post challenge. Blood and serum samples were collected for nonspecific immune parameters on 14, 28 and 42 days of feeding and growth performance was evaluated at the end of experiment. The results revealed that fishes fed with andrographolide showed significant (p < 0.05) increase in NBT levels, myeloperoxidase activity, phagocytic activity, serum lysozyme activity, and serum antiprotease activity when compared to the control group. The weight gain, specific growth rate, feed conversion ratio and protein efficiency ratio of fishes fed with andrographolide were found to be significantly (p < 0.05) differed compared with control. Dietary andrographolide at the level of 0.10% showed significantly (P < 0.05) higher RPS (74.06%) against A. hydrophila infection than control. The results revealed that andrographolide supplemented diet has a stimulatory effect on non-specific immune parameters along with improved growth performance and increased disease resistance against A. hydrophila infection in L. rohita fingerlings.

Authors+Show Affiliations

Central Institute of Fisheries Education, Panch Marg, Off Yari Road, Versova, Mumbai 400 061, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23973382

Citation

Basha, Kusunur Ahamed, et al. "Effect of Dietary Supplemented Andrographolide On Growth, Non-specific Immune Parameters and Resistance Against Aeromonas Hydrophila in Labeo Rohita (Hamilton)." Fish & Shellfish Immunology, vol. 35, no. 5, 2013, pp. 1433-41.
Basha KA, Raman RP, Prasad KP, et al. Effect of dietary supplemented andrographolide on growth, non-specific immune parameters and resistance against Aeromonas hydrophila in Labeo rohita (Hamilton). Fish Shellfish Immunol. 2013;35(5):1433-41.
Basha, K. A., Raman, R. P., Prasad, K. P., Kumar, K., Nilavan, E., & Kumar, S. (2013). Effect of dietary supplemented andrographolide on growth, non-specific immune parameters and resistance against Aeromonas hydrophila in Labeo rohita (Hamilton). Fish & Shellfish Immunology, 35(5), 1433-41. https://doi.org/10.1016/j.fsi.2013.08.005
Basha KA, et al. Effect of Dietary Supplemented Andrographolide On Growth, Non-specific Immune Parameters and Resistance Against Aeromonas Hydrophila in Labeo Rohita (Hamilton). Fish Shellfish Immunol. 2013;35(5):1433-41. PubMed PMID: 23973382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary supplemented andrographolide on growth, non-specific immune parameters and resistance against Aeromonas hydrophila in Labeo rohita (Hamilton). AU - Basha,Kusunur Ahamed, AU - Raman,Ram Prakash, AU - Prasad,Kurcheti Pani, AU - Kumar,Kundan, AU - Nilavan,Ezhil, AU - Kumar,Saurav, Y1 - 2013/08/22/ PY - 2013/05/01/received PY - 2013/08/03/revised PY - 2013/08/08/accepted PY - 2013/8/27/entrez PY - 2013/8/27/pubmed PY - 2014/5/10/medline KW - Aeromonas hydrophila KW - Andrographolide KW - Immune system KW - Immunostimulant KW - Non-specific SP - 1433 EP - 41 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol VL - 35 IS - 5 N2 - The present study evaluated the effect of dietary andrographolide (EC 50%) on growth, non-specific immune parameters and disease resistance against Aeromonas hydrophila infection in Indian major carp, Labeo rohita fingerlings. Fishes were fed with formulated diet containing andrographolide as T0 (0.00%), T1 (0.05%), T2 (0.10%), T3 (0.20%), T4 (0.40%) and T5 (0.80%) for 42 days. Fishes were challenged with A. hydrophila 42 days post feeding and relative percentage survival (RPS) was recorded over 14 days post challenge. Blood and serum samples were collected for nonspecific immune parameters on 14, 28 and 42 days of feeding and growth performance was evaluated at the end of experiment. The results revealed that fishes fed with andrographolide showed significant (p < 0.05) increase in NBT levels, myeloperoxidase activity, phagocytic activity, serum lysozyme activity, and serum antiprotease activity when compared to the control group. The weight gain, specific growth rate, feed conversion ratio and protein efficiency ratio of fishes fed with andrographolide were found to be significantly (p < 0.05) differed compared with control. Dietary andrographolide at the level of 0.10% showed significantly (P < 0.05) higher RPS (74.06%) against A. hydrophila infection than control. The results revealed that andrographolide supplemented diet has a stimulatory effect on non-specific immune parameters along with improved growth performance and increased disease resistance against A. hydrophila infection in L. rohita fingerlings. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/23973382/Effect_of_dietary_supplemented_andrographolide_on_growth_non_specific_immune_parameters_and_resistance_against_Aeromonas_hydrophila_in_Labeo_rohita__Hamilton__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(13)00707-9 DB - PRIME DP - Unbound Medicine ER -