Tags

Type your tag names separated by a space and hit enter

Protective effect of melatonin on methamphetamine-induced apoptosis in glioma cell line.
Neurotox Res. 2014 Apr; 25(3):286-94.NR

Abstract

Methamphetamine (METH) is a highly addictive drug causing neurodegenerative diseases. METH has been known to be neurotoxic by inducing oxidative stress, free radical, and pro-inflammatory cytokines. Previous studies have shown that METH could induce neuron and glial cell death, especially inducing glial cell-mediated neurotoxicity that plays a critical role in stress-induced central nervous system damage. Therefore, the aim of the present study is to explore the mechanisms of METH-induced cell death in the glial cell. METH-induced glial cells death is mediated via mitochondrial damage pathway. METH activates the upregulation of the Bax, cytochrome c, cleavage caspase 9 and 3 proteins, and downregulation of Bcl-XL protein in cascade. Pretreatment with melatonin, a neurohormone secreted by the pineal gland, effectively reduced glial cell death. Moreover, melatonin increased the Bcl-XL/Bax ratio but reduced the level of cytochrome c, cleavage caspase 9 and 3 proteins. Therefore, these results demonstrated that melatonin could reduce the cytotoxic effect of METH by decreasing the mitochondrial death pathway activation in glial cells. This outcome suggests that melatonin might be beneficial as the neuroprotection in neurodegenerative diseases caused by METH or other pathogens.

Authors+Show Affiliations

Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23975636

Citation

Jumnongprakhon, Pichaya, et al. "Protective Effect of Melatonin On Methamphetamine-induced Apoptosis in Glioma Cell Line." Neurotoxicity Research, vol. 25, no. 3, 2014, pp. 286-94.
Jumnongprakhon P, Govitrapong P, Tocharus C, et al. Protective effect of melatonin on methamphetamine-induced apoptosis in glioma cell line. Neurotox Res. 2014;25(3):286-94.
Jumnongprakhon, P., Govitrapong, P., Tocharus, C., Tungkum, W., & Tocharus, J. (2014). Protective effect of melatonin on methamphetamine-induced apoptosis in glioma cell line. Neurotoxicity Research, 25(3), 286-94. https://doi.org/10.1007/s12640-013-9419-y
Jumnongprakhon P, et al. Protective Effect of Melatonin On Methamphetamine-induced Apoptosis in Glioma Cell Line. Neurotox Res. 2014;25(3):286-94. PubMed PMID: 23975636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of melatonin on methamphetamine-induced apoptosis in glioma cell line. AU - Jumnongprakhon,Pichaya, AU - Govitrapong,Piyarat, AU - Tocharus,Chainarong, AU - Tungkum,Wanida, AU - Tocharus,Jiraporn, Y1 - 2013/08/23/ PY - 2013/02/06/received PY - 2013/08/09/accepted PY - 2013/08/06/revised PY - 2013/8/27/entrez PY - 2013/8/27/pubmed PY - 2014/11/6/medline SP - 286 EP - 94 JF - Neurotoxicity research JO - Neurotox Res VL - 25 IS - 3 N2 - Methamphetamine (METH) is a highly addictive drug causing neurodegenerative diseases. METH has been known to be neurotoxic by inducing oxidative stress, free radical, and pro-inflammatory cytokines. Previous studies have shown that METH could induce neuron and glial cell death, especially inducing glial cell-mediated neurotoxicity that plays a critical role in stress-induced central nervous system damage. Therefore, the aim of the present study is to explore the mechanisms of METH-induced cell death in the glial cell. METH-induced glial cells death is mediated via mitochondrial damage pathway. METH activates the upregulation of the Bax, cytochrome c, cleavage caspase 9 and 3 proteins, and downregulation of Bcl-XL protein in cascade. Pretreatment with melatonin, a neurohormone secreted by the pineal gland, effectively reduced glial cell death. Moreover, melatonin increased the Bcl-XL/Bax ratio but reduced the level of cytochrome c, cleavage caspase 9 and 3 proteins. Therefore, these results demonstrated that melatonin could reduce the cytotoxic effect of METH by decreasing the mitochondrial death pathway activation in glial cells. This outcome suggests that melatonin might be beneficial as the neuroprotection in neurodegenerative diseases caused by METH or other pathogens. SN - 1476-3524 UR - https://www.unboundmedicine.com/medline/citation/23975636/Protective_effect_of_melatonin_on_methamphetamine_induced_apoptosis_in_glioma_cell_line_ L2 - https://dx.doi.org/10.1007/s12640-013-9419-y DB - PRIME DP - Unbound Medicine ER -