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From SARS coronavirus to novel animal and human coronaviruses.
J Thorac Dis. 2013 Aug; 5 Suppl 2:S103-8.JT

Abstract

In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) caused one of the most devastating epidemics known to the developed world. There were two important lessons from this epidemic. Firstly, coronaviruses, in addition to influenza viruses, can cause severe and rapidly spreading human infections. Secondly, bats can serve as the origin and natural animal reservoir of deadly human viruses. Since then, researchers around the world, especially those in Asia where SARS-CoV was first identified, have turned their focus to find novel coronaviruses infecting humans, bats, and other animals. Two human coronaviruses, HCoV-HKU1 and HCoV-NL63, were identified shortly after the SARS-CoV epidemic as common causes of human respiratory tract infections. In 2012, a novel human coronavirus, now called Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in the Middle East to cause fatal human infections in three continents. MERS-CoV human infection is similar to SARS-CoV in having a high fatality rate and the ability to spread from person to person which resulted in secondary cases among close contacts including healthcare workers without travel history to the Middle East. Both viruses also have close relationships with bat coronaviruses. New cases of MERS-CoV infection in humans continue to occur with the origins of the virus still unknown in many cases. A multifaceted approach is necessary to control this evolving MERS-CoV outbreak. Source identification requires detailed epidemiological studies of the infected patients and enhanced surveillance of MERS-CoV or similar coronaviruses in humans and animals. Early diagnosis of infected patients and appropriate infection control measures will limit the spread in hospitals, while social distancing strategies may be necessary to control the outbreak in communities if it remained uncontrolled as in the SARS epidemic.

Authors+Show Affiliations

State Key Laboratory of Emerging Infectious Diseases, the University of Hong Kong, Hong Kong Special Administrative Region, China ; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23977429

Citation

To, Kelvin K W., et al. "From SARS Coronavirus to Novel Animal and Human Coronaviruses." Journal of Thoracic Disease, vol. 5 Suppl 2, 2013, pp. S103-8.
To KK, Hung IF, Chan JF, et al. From SARS coronavirus to novel animal and human coronaviruses. J Thorac Dis. 2013;5 Suppl 2:S103-8.
To, K. K., Hung, I. F., Chan, J. F., & Yuen, K. Y. (2013). From SARS coronavirus to novel animal and human coronaviruses. Journal of Thoracic Disease, 5 Suppl 2, S103-8. https://doi.org/10.3978/j.issn.2072-1439.2013.06.02
To KK, et al. From SARS Coronavirus to Novel Animal and Human Coronaviruses. J Thorac Dis. 2013;5 Suppl 2:S103-8. PubMed PMID: 23977429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From SARS coronavirus to novel animal and human coronaviruses. AU - To,Kelvin K W, AU - Hung,Ivan F N, AU - Chan,Jasper F W, AU - Yuen,Kwok-Yung, PY - 2013/05/15/received PY - 2013/06/04/accepted PY - 2013/8/27/entrez PY - 2013/8/27/pubmed PY - 2013/8/27/medline KW - Middle East respiratory syndrome coronavirus (MERS-CoV) KW - Severe acute respiratory syndrome coronavirus (SARS-CoV) KW - novel coronaviruses SP - S103 EP - 8 JF - Journal of thoracic disease JO - J Thorac Dis VL - 5 Suppl 2 N2 - In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) caused one of the most devastating epidemics known to the developed world. There were two important lessons from this epidemic. Firstly, coronaviruses, in addition to influenza viruses, can cause severe and rapidly spreading human infections. Secondly, bats can serve as the origin and natural animal reservoir of deadly human viruses. Since then, researchers around the world, especially those in Asia where SARS-CoV was first identified, have turned their focus to find novel coronaviruses infecting humans, bats, and other animals. Two human coronaviruses, HCoV-HKU1 and HCoV-NL63, were identified shortly after the SARS-CoV epidemic as common causes of human respiratory tract infections. In 2012, a novel human coronavirus, now called Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in the Middle East to cause fatal human infections in three continents. MERS-CoV human infection is similar to SARS-CoV in having a high fatality rate and the ability to spread from person to person which resulted in secondary cases among close contacts including healthcare workers without travel history to the Middle East. Both viruses also have close relationships with bat coronaviruses. New cases of MERS-CoV infection in humans continue to occur with the origins of the virus still unknown in many cases. A multifaceted approach is necessary to control this evolving MERS-CoV outbreak. Source identification requires detailed epidemiological studies of the infected patients and enhanced surveillance of MERS-CoV or similar coronaviruses in humans and animals. Early diagnosis of infected patients and appropriate infection control measures will limit the spread in hospitals, while social distancing strategies may be necessary to control the outbreak in communities if it remained uncontrolled as in the SARS epidemic. SN - 2072-1439 UR - https://www.unboundmedicine.com/medline/citation/23977429/From_SARS_coronavirus_to_novel_animal_and_human_coronaviruses_ L2 - https://doi.org/10.3978/j.issn.2072-1439.2013.06.02 DB - PRIME DP - Unbound Medicine ER -
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