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Impact of exercise training on redox signaling in cardiovascular diseases.
Food Chem Toxicol. 2013 Dec; 62:107-19.FC

Abstract

Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of cardiovascular diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology of cardiovascular diseases such as ischemia-reperfusion injury, hypertension and heart failure. We also summarize the benefits of exercise training in tackling the hyperactivation of cellular oxidases and mitochondrial dysfunction seen in cardiovascular diseases.

Authors+Show Affiliations

Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23978413

Citation

Campos, Juliane C., et al. "Impact of Exercise Training On Redox Signaling in Cardiovascular Diseases." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 62, 2013, pp. 107-19.
Campos JC, Gomes KM, Ferreira JC. Impact of exercise training on redox signaling in cardiovascular diseases. Food Chem Toxicol. 2013;62:107-19.
Campos, J. C., Gomes, K. M., & Ferreira, J. C. (2013). Impact of exercise training on redox signaling in cardiovascular diseases. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 62, 107-19. https://doi.org/10.1016/j.fct.2013.08.035
Campos JC, Gomes KM, Ferreira JC. Impact of Exercise Training On Redox Signaling in Cardiovascular Diseases. Food Chem Toxicol. 2013;62:107-19. PubMed PMID: 23978413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of exercise training on redox signaling in cardiovascular diseases. AU - Campos,Juliane C, AU - Gomes,Kátia M S, AU - Ferreira,Julio C B, Y1 - 2013/08/24/ PY - 2013/06/24/received PY - 2013/08/05/revised PY - 2013/08/18/accepted PY - 2013/8/28/entrez PY - 2013/8/28/pubmed PY - 2016/5/7/medline KW - ()OH KW - 4-HNE KW - 4-hydroxy-2-nonenal KW - ATP KW - Bioenergetics KW - Cardiac disease KW - Cu ZnSOD KW - ETC KW - Free radicals KW - GPX KW - GSH KW - GSSG KW - H(2)O(2) KW - HNO KW - MAO KW - MDA KW - MnSOD KW - NADH KW - NADPH oxidase isoform KW - NAPDH KW - NO() KW - NO(+) KW - NOS KW - NOX KW - ONOO() KW - Oxidative metabolism KW - Oxidative stress KW - Physical activity KW - RNS KW - ROS KW - SOD KW - VO(2) max KW - adenosine triphosphate KW - constitutive endothelial NOS KW - copper–zinc superoxide dismutase KW - eNOS KW - electron transport chain KW - glutathione peroxidase KW - hydrogen peroxide KW - hydroxyl radical KW - iNOS KW - inducible NOS KW - malondialdehyde KW - manganese superoxide dismutase KW - maximal oxygen consumption KW - mitochondrial nitric oxide synthase KW - monoamine oxidase KW - mtNOS KW - nicotinamide adenine dinucleotide KW - nicotinamide adenine dinucleotide phosphate KW - nitric oxide KW - nitric oxide synthase KW - nitrogen dioxide KW - nitrosonium KW - nitroxyl KW - oxidized glutathione KW - peroxynitrite KW - reactive nitrogen species KW - reactive oxygen species KW - reduced glutathione KW - superoxide KW - superoxide dismutase SP - 107 EP - 19 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 62 N2 - Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of cardiovascular diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology of cardiovascular diseases such as ischemia-reperfusion injury, hypertension and heart failure. We also summarize the benefits of exercise training in tackling the hyperactivation of cellular oxidases and mitochondrial dysfunction seen in cardiovascular diseases. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23978413/Impact_of_exercise_training_on_redox_signaling_in_cardiovascular_diseases_ DB - PRIME DP - Unbound Medicine ER -