Tags

Type your tag names separated by a space and hit enter

Bioappearance and pharmacokinetics of bioactives upon coffee consumption.
Anal Bioanal Chem. 2013 Oct; 405(26):8487-503.AB

Abstract

Habitual consumption of medium amounts of coffee over the whole life-span is hypothesized to reduce the risk to develop diabetes type 2 (DM2) and Alzheimer's disease (AD). To identify putative bioactive coffee-derived metabolites, first, pooled urine from coffee drinkers and non-coffee drinkers were screened by UPLC-HDMS. After statistical data analysis, trigonelline, dimethylxanthines and monomethylxanthines, and ferulic acid conjugates were identified as the major metabolites found after coffee consumption. For quantitative analysis of these markers in body fluids, targeted methods based on stable-isotope dilution and UPLC-MS/MS were developed and applied to plasma samples from a coffee intervention study (n = 13 volunteers) who consumed a single cup of caffeinated coffee brew after a 10-day washout period. Chlorogenic acid-derived metabolites were found to be separated into two groups showing different pharmacokinetic properties. The first group comprised, e.g., ferulic acid and feruloyl sulfate and showed early appearance in the plasma (~1 h). The second group contained particularly chlorogenic acid metabolites formed by the intestinal microflora, appearing late and persisting in the plasma (>6 h). Trigonelline appeared early but persisted with calculated half-life times ~5 h. The plasma levels of caffeine metabolites significantly and progressively increased 2-4 h after coffee consumption and did not reach c max within the time frame of the study. The pharmacokinetic profiles suggest that particularly trigonelline, caffeine, its metabolites, as well as late appearing dihydroferulic acid, feruloylglycine and dihydroferulic acid sulfate formed from chlorogenic acid by the intestinal microflora accumulate in the plasma due to their long half-life times during habitual consumption of several cups of coffee distributed over the day. Since some of these metabolites have been reported to show antioxidant effects in vivo, antioxidant-response-element activating potential, and neuroprotective properties, respectively, some of these key metabolites might account for the inflammation- and DM2/AD risk reducing effects reported for habitual life time consumption of coffee.

Authors+Show Affiliations

Chair of Food Chemistry and Molecular Sensory Science, Technische Universität München, Lise-Meitner-Str 34, 85354, Freising, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23982107

Citation

Lang, Roman, et al. "Bioappearance and Pharmacokinetics of Bioactives Upon Coffee Consumption." Analytical and Bioanalytical Chemistry, vol. 405, no. 26, 2013, pp. 8487-503.
Lang R, Dieminger N, Beusch A, et al. Bioappearance and pharmacokinetics of bioactives upon coffee consumption. Anal Bioanal Chem. 2013;405(26):8487-503.
Lang, R., Dieminger, N., Beusch, A., Lee, Y. M., Dunkel, A., Suess, B., Skurk, T., Wahl, A., Hauner, H., & Hofmann, T. (2013). Bioappearance and pharmacokinetics of bioactives upon coffee consumption. Analytical and Bioanalytical Chemistry, 405(26), 8487-503. https://doi.org/10.1007/s00216-013-7288-0
Lang R, et al. Bioappearance and Pharmacokinetics of Bioactives Upon Coffee Consumption. Anal Bioanal Chem. 2013;405(26):8487-503. PubMed PMID: 23982107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioappearance and pharmacokinetics of bioactives upon coffee consumption. AU - Lang,Roman, AU - Dieminger,Natalie, AU - Beusch,Anja, AU - Lee,Yu-Mi, AU - Dunkel,Andreas, AU - Suess,Barbara, AU - Skurk,Thomas, AU - Wahl,Anika, AU - Hauner,Hans, AU - Hofmann,Thomas, Y1 - 2013/08/28/ PY - 2013/05/31/received PY - 2013/08/01/accepted PY - 2013/07/25/revised PY - 2013/8/29/entrez PY - 2013/8/29/pubmed PY - 2014/6/13/medline SP - 8487 EP - 503 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 405 IS - 26 N2 - Habitual consumption of medium amounts of coffee over the whole life-span is hypothesized to reduce the risk to develop diabetes type 2 (DM2) and Alzheimer's disease (AD). To identify putative bioactive coffee-derived metabolites, first, pooled urine from coffee drinkers and non-coffee drinkers were screened by UPLC-HDMS. After statistical data analysis, trigonelline, dimethylxanthines and monomethylxanthines, and ferulic acid conjugates were identified as the major metabolites found after coffee consumption. For quantitative analysis of these markers in body fluids, targeted methods based on stable-isotope dilution and UPLC-MS/MS were developed and applied to plasma samples from a coffee intervention study (n = 13 volunteers) who consumed a single cup of caffeinated coffee brew after a 10-day washout period. Chlorogenic acid-derived metabolites were found to be separated into two groups showing different pharmacokinetic properties. The first group comprised, e.g., ferulic acid and feruloyl sulfate and showed early appearance in the plasma (~1 h). The second group contained particularly chlorogenic acid metabolites formed by the intestinal microflora, appearing late and persisting in the plasma (>6 h). Trigonelline appeared early but persisted with calculated half-life times ~5 h. The plasma levels of caffeine metabolites significantly and progressively increased 2-4 h after coffee consumption and did not reach c max within the time frame of the study. The pharmacokinetic profiles suggest that particularly trigonelline, caffeine, its metabolites, as well as late appearing dihydroferulic acid, feruloylglycine and dihydroferulic acid sulfate formed from chlorogenic acid by the intestinal microflora accumulate in the plasma due to their long half-life times during habitual consumption of several cups of coffee distributed over the day. Since some of these metabolites have been reported to show antioxidant effects in vivo, antioxidant-response-element activating potential, and neuroprotective properties, respectively, some of these key metabolites might account for the inflammation- and DM2/AD risk reducing effects reported for habitual life time consumption of coffee. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/23982107/Bioappearance_and_pharmacokinetics_of_bioactives_upon_coffee_consumption_ L2 - https://dx.doi.org/10.1007/s00216-013-7288-0 DB - PRIME DP - Unbound Medicine ER -