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Effects of dietary n-3 fatty acids on the phospholipid molecular species of monkey brain.
J Neurochem. 1990 Oct; 55(4):1200-7.JN

Abstract

We examined the changes in the molecular species of brain ethanolamine glycerophospholipids of monkeys fed diets containing widely ranging amounts of n-3 fatty acids. Two groups of rhesus monkeys were fed pre- and postnatally either a control diet (soy oil; containing 8% of fatty acids as 18:3n-3) or a deficient diet (safflower oil; containing less than 0.3% 18:3n-3). The brains of these animals were analyzed at 22 months of age. A third group of monkeys was fed the safflower oil diet to 22 months of age and then switched to a fish oil diet (28% long-chain n-3 fatty acids) for 1-2 years before autopsy. The molecular species of the diacyl, alkylacyl, and alkenylacyl ethanolamine glycerophospholipids from frontal cortex were separated by HPLC. A total of 24 molecular species were identified. Fatty acids in the sn-2 position differed markedly among the diet groups, but the sn-1 position always contained only 16:0, 18:0, or 18:1. In the diacyl subclass of the control brain, the n-3 molecular species represented 41% of total and the n-6 species 45%, whereas in the deficient brain the n-3 molecular species decreased to 9% and n-6 molecular species increased to 77%. The fatty acid 22:5n-6 did not replace 22:6n-3 in a symmetrical fashion in the molecular species of the deficient brain. In the brains of the fish oil-fed monkeys, the n-3 molecular species amounted to 61% and n-6 molecular species were reduced to 25%. The species 18:1-22:6, 16:0-22:6, and 18:0-22:6 generally changed proportionally in response to diet.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, Oregon Health Sciences University, Portland 97201.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2398354

Citation

Lin, D S., et al. "Effects of Dietary N-3 Fatty Acids On the Phospholipid Molecular Species of Monkey Brain." Journal of Neurochemistry, vol. 55, no. 4, 1990, pp. 1200-7.
Lin DS, Connor WE, Anderson GJ, et al. Effects of dietary n-3 fatty acids on the phospholipid molecular species of monkey brain. J Neurochem. 1990;55(4):1200-7.
Lin, D. S., Connor, W. E., Anderson, G. J., & Neuringer, M. (1990). Effects of dietary n-3 fatty acids on the phospholipid molecular species of monkey brain. Journal of Neurochemistry, 55(4), 1200-7.
Lin DS, et al. Effects of Dietary N-3 Fatty Acids On the Phospholipid Molecular Species of Monkey Brain. J Neurochem. 1990;55(4):1200-7. PubMed PMID: 2398354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary n-3 fatty acids on the phospholipid molecular species of monkey brain. AU - Lin,D S, AU - Connor,W E, AU - Anderson,G J, AU - Neuringer,M, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 1200 EP - 7 JF - Journal of neurochemistry JO - J Neurochem VL - 55 IS - 4 N2 - We examined the changes in the molecular species of brain ethanolamine glycerophospholipids of monkeys fed diets containing widely ranging amounts of n-3 fatty acids. Two groups of rhesus monkeys were fed pre- and postnatally either a control diet (soy oil; containing 8% of fatty acids as 18:3n-3) or a deficient diet (safflower oil; containing less than 0.3% 18:3n-3). The brains of these animals were analyzed at 22 months of age. A third group of monkeys was fed the safflower oil diet to 22 months of age and then switched to a fish oil diet (28% long-chain n-3 fatty acids) for 1-2 years before autopsy. The molecular species of the diacyl, alkylacyl, and alkenylacyl ethanolamine glycerophospholipids from frontal cortex were separated by HPLC. A total of 24 molecular species were identified. Fatty acids in the sn-2 position differed markedly among the diet groups, but the sn-1 position always contained only 16:0, 18:0, or 18:1. In the diacyl subclass of the control brain, the n-3 molecular species represented 41% of total and the n-6 species 45%, whereas in the deficient brain the n-3 molecular species decreased to 9% and n-6 molecular species increased to 77%. The fatty acid 22:5n-6 did not replace 22:6n-3 in a symmetrical fashion in the molecular species of the deficient brain. In the brains of the fish oil-fed monkeys, the n-3 molecular species amounted to 61% and n-6 molecular species were reduced to 25%. The species 18:1-22:6, 16:0-22:6, and 18:0-22:6 generally changed proportionally in response to diet.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/2398354/Effects_of_dietary_n_3_fatty_acids_on_the_phospholipid_molecular_species_of_monkey_brain_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3042&date=1990&volume=55&issue=4&spage=1200 DB - PRIME DP - Unbound Medicine ER -