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A six-month randomized controlled trial of whole soy and isoflavones daidzein on body composition in equol-producing postmenopausal women with prehypertension.
J Obes 2013; 2013:359763JO

Abstract

OBJECTIVES

This paper reported the effects of commonly used whole soy foods (soy flour) and purified daidzein (one of the major isoflavones and the precursor of equol) on changes in anthropometric measurements and body composition in a 6-month double-blind, randomized, placebo-controlled trial among prehypertensive postmenopausal women who are also equol producers.

METHODS

270 eligible women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) daily each for 6 months. Anthropometric indicators and body composition were measured before and after intervention.

RESULTS

253 subjects completed the study with good compliance. Urinary isoflavones levels suggested good compliance of subjects with supplementation. Whole soy and purified daidzein had no significant effect on body weight, body mass index (BMI), waist and hip circumferences, waist to hip ratio (WHR), body fat percentage, fat mass, and free fat mass.

CONCLUSION

Six-month consumption of whole soy and purified daidzein at provided dosage had no improvement on body weight and composition compared with isocaloric milk placebo among prehypertensive equol-producing postmenopausal women. This trial is registered with ClinicalTrials.gov NCT01270737.

Authors+Show Affiliations

Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23984051

Citation

Liu, Zhao-Min, et al. "A Six-month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein On Body Composition in Equol-producing Postmenopausal Women With Prehypertension." Journal of Obesity, vol. 2013, 2013, p. 359763.
Liu ZM, Ho SC, Chen YM, et al. A six-month randomized controlled trial of whole soy and isoflavones daidzein on body composition in equol-producing postmenopausal women with prehypertension. J Obes. 2013;2013:359763.
Liu, Z. M., Ho, S. C., Chen, Y. M., & Woo, J. (2013). A six-month randomized controlled trial of whole soy and isoflavones daidzein on body composition in equol-producing postmenopausal women with prehypertension. Journal of Obesity, 2013, p. 359763. doi:10.1155/2013/359763.
Liu ZM, et al. A Six-month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein On Body Composition in Equol-producing Postmenopausal Women With Prehypertension. J Obes. 2013;2013:359763. PubMed PMID: 23984051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A six-month randomized controlled trial of whole soy and isoflavones daidzein on body composition in equol-producing postmenopausal women with prehypertension. AU - Liu,Zhao-Min, AU - Ho,Suzanne C, AU - Chen,Yu-Ming, AU - Woo,Jean, Y1 - 2013/08/01/ PY - 2013/02/28/received PY - 2013/05/27/accepted PY - 2013/8/29/entrez PY - 2013/8/29/pubmed PY - 2013/12/24/medline SP - 359763 EP - 359763 JF - Journal of obesity JO - J Obes VL - 2013 N2 - OBJECTIVES: This paper reported the effects of commonly used whole soy foods (soy flour) and purified daidzein (one of the major isoflavones and the precursor of equol) on changes in anthropometric measurements and body composition in a 6-month double-blind, randomized, placebo-controlled trial among prehypertensive postmenopausal women who are also equol producers. METHODS: 270 eligible women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) daily each for 6 months. Anthropometric indicators and body composition were measured before and after intervention. RESULTS: 253 subjects completed the study with good compliance. Urinary isoflavones levels suggested good compliance of subjects with supplementation. Whole soy and purified daidzein had no significant effect on body weight, body mass index (BMI), waist and hip circumferences, waist to hip ratio (WHR), body fat percentage, fat mass, and free fat mass. CONCLUSION: Six-month consumption of whole soy and purified daidzein at provided dosage had no improvement on body weight and composition compared with isocaloric milk placebo among prehypertensive equol-producing postmenopausal women. This trial is registered with ClinicalTrials.gov NCT01270737. SN - 2090-0716 UR - https://www.unboundmedicine.com/medline/citation/23984051/A_six_month_randomized_controlled_trial_of_whole_soy_and_isoflavones_daidzein_on_body_composition_in_equol_producing_postmenopausal_women_with_prehypertension_ L2 - https://dx.doi.org/10.1155/2013/359763 DB - PRIME DP - Unbound Medicine ER -