Tags

Type your tag names separated by a space and hit enter

Celiac disease and autoimmune-associated conditions.
Biomed Res Int 2013; 2013:127589BR

Abstract

Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage.

Authors+Show Affiliations

Gastroenterology Unit, Central University Hospital of Asturias, Celestino Villamil, 33006 Oviedo, Principality of Asturias, Spain.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23984314

Citation

Lauret, Eugenia, and Luis Rodrigo. "Celiac Disease and Autoimmune-associated Conditions." BioMed Research International, vol. 2013, 2013, p. 127589.
Lauret E, Rodrigo L. Celiac disease and autoimmune-associated conditions. Biomed Res Int. 2013;2013:127589.
Lauret, E., & Rodrigo, L. (2013). Celiac disease and autoimmune-associated conditions. BioMed Research International, 2013, p. 127589. doi:10.1155/2013/127589.
Lauret E, Rodrigo L. Celiac Disease and Autoimmune-associated Conditions. Biomed Res Int. 2013;2013:127589. PubMed PMID: 23984314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Celiac disease and autoimmune-associated conditions. AU - Lauret,Eugenia, AU - Rodrigo,Luis, Y1 - 2013/07/24/ PY - 2013/05/10/received PY - 2013/06/20/accepted PY - 2013/8/29/entrez PY - 2013/8/29/pubmed PY - 2014/3/19/medline SP - 127589 EP - 127589 JF - BioMed research international JO - Biomed Res Int VL - 2013 N2 - Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/23984314/full_citation L2 - https://dx.doi.org/10.1155/2013/127589 DB - PRIME DP - Unbound Medicine ER -