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Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk.
J Natl Cancer Inst. 2013 Oct 16; 105(20):1571-8.JNCI

Abstract

BACKGROUND

Adult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first full-term pregnancy. No study has characterized the contribution of alcohol consumption during this interval to risks of proliferative benign breast disease (BBD) and breast cancer.

METHODS

We used data from 91,005 parous women in the Nurses' Health Study II who had no cancer history, completed questions on early alcohol consumption in 1989, and were followed through June 30, 2009, to analyze breast cancer risk. A subset of 60,093 women who had no history of BBD or cancer in 1991 and were followed through June 30, 2001, were included in the analysis of proliferative BBD. Relative risks (RRs) were estimated using Cox proportional hazard regression.

RESULTS

We identified 1609 breast cancer cases and 970 proliferative BBD cases confirmed by central histology review. Alcohol consumption between menarche and first pregnancy, adjusted for drinking after first pregnancy, was associated with risks of breast cancer (RR = 1.11 per 10 g/day intake; 95% confidence interval [CI] = 1.00 to 1.23) and proliferative BBD (RR = 1.16 per 10 g/day intake; 95% CI = 1.02 to 1.32). Drinking after first pregnancy had a similar risk for breast cancer (RR = 1.09 per 10 g/day intake; 95% CI = 0.96 to 1.23) but not for BBD. The association between drinking before first pregnancy and breast neoplasia appeared to be stronger with longer menarche to first pregnancy intervals.

CONCLUSIONS

Alcohol consumption before first pregnancy was consistently associated with increased risks of proliferative BBD and breast cancer.

Authors+Show Affiliations

Affiliations of authors: Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO (YL, GAC); Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO (GAC); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (BR, CSB, WYC, RMT); Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (LCC, SJS, JLC); Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA (WCW).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23985142

Citation

Liu, Ying, et al. "Alcohol Intake Between Menarche and First Pregnancy: a Prospective Study of Breast Cancer Risk." Journal of the National Cancer Institute, vol. 105, no. 20, 2013, pp. 1571-8.
Liu Y, Colditz GA, Rosner B, et al. Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk. J Natl Cancer Inst. 2013;105(20):1571-8.
Liu, Y., Colditz, G. A., Rosner, B., Berkey, C. S., Collins, L. C., Schnitt, S. J., Connolly, J. L., Chen, W. Y., Willett, W. C., & Tamimi, R. M. (2013). Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk. Journal of the National Cancer Institute, 105(20), 1571-8. https://doi.org/10.1093/jnci/djt213
Liu Y, et al. Alcohol Intake Between Menarche and First Pregnancy: a Prospective Study of Breast Cancer Risk. J Natl Cancer Inst. 2013 Oct 16;105(20):1571-8. PubMed PMID: 23985142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk. AU - Liu,Ying, AU - Colditz,Graham A, AU - Rosner,Bernard, AU - Berkey,Catherine S, AU - Collins,Laura C, AU - Schnitt,Stuart J, AU - Connolly,James L, AU - Chen,Wendy Y, AU - Willett,Walter C, AU - Tamimi,Rulla M, Y1 - 2013/08/28/ PY - 2013/8/30/entrez PY - 2013/8/30/pubmed PY - 2013/12/16/medline SP - 1571 EP - 8 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 105 IS - 20 N2 - BACKGROUND: Adult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first full-term pregnancy. No study has characterized the contribution of alcohol consumption during this interval to risks of proliferative benign breast disease (BBD) and breast cancer. METHODS: We used data from 91,005 parous women in the Nurses' Health Study II who had no cancer history, completed questions on early alcohol consumption in 1989, and were followed through June 30, 2009, to analyze breast cancer risk. A subset of 60,093 women who had no history of BBD or cancer in 1991 and were followed through June 30, 2001, were included in the analysis of proliferative BBD. Relative risks (RRs) were estimated using Cox proportional hazard regression. RESULTS: We identified 1609 breast cancer cases and 970 proliferative BBD cases confirmed by central histology review. Alcohol consumption between menarche and first pregnancy, adjusted for drinking after first pregnancy, was associated with risks of breast cancer (RR = 1.11 per 10 g/day intake; 95% confidence interval [CI] = 1.00 to 1.23) and proliferative BBD (RR = 1.16 per 10 g/day intake; 95% CI = 1.02 to 1.32). Drinking after first pregnancy had a similar risk for breast cancer (RR = 1.09 per 10 g/day intake; 95% CI = 0.96 to 1.23) but not for BBD. The association between drinking before first pregnancy and breast neoplasia appeared to be stronger with longer menarche to first pregnancy intervals. CONCLUSIONS: Alcohol consumption before first pregnancy was consistently associated with increased risks of proliferative BBD and breast cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/23985142/Alcohol_intake_between_menarche_and_first_pregnancy:_a_prospective_study_of_breast_cancer_risk_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djt213 DB - PRIME DP - Unbound Medicine ER -